JOURNAL ARTICLE

Genetic analysis of rabies virus isolates in the Philippines

Akira Nishizono, Kazuaki Mannen, Luningning P Elio-Villa, Seiichi Tanaka, Kang-sheng Li, Kumato Mifune, Benito F Arca, Arturo Cabanban, Benjamin Martinez, Arlito Rodriguez, Victor C Atienza, Rolando Camba, Nilo Resontoc
Microbiology and Immunology 2002, 46 (6): 413-7
12153119
To determine the genetic characteristics of the rabies virus in the Philippines, 59 rabies virus isolates were obtained from domestic rabid dogs and their partial nucleotide sequences of nucleoprotein (N) gene were compared. Based on comparison with reported sequences, phylogenetic analysis revealed that all isolates from the Philippines had close genetic relations and formed two subgroups. The Philippines isolates belonged to a different lineage from other Asian isolates but were closer to them than to terrestrial isolates and laboratory strains. Several specific nucleotide and amino acid substitutions were observed among the Philippines isolates. Our results suggest that rabies viruses in the Philippines might have a characteristic evolution.

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