Autoantibodies to transducin in a patient with melanoma-associated retinopathy

Michael J Potter, Grazyna Adamus, Shelagh M Szabo, Rehwa Lee, Kam Mohaseb, Darren Behn
American Journal of Ophthalmology 2002, 134 (1): 128-30

PURPOSE: To report novel immunoreactivity in a patient with melanoma-associated retinopathy.

DESIGN: Retrospective case report and experimental study.

METHODS: A 32-year-old woman with a history of metastatic melanoma presented with bilateral decreased visual acuity. Electroretinography, Goldmann perimetry, immunohistochemistry, and Western blotting of her serum were performed.

RESULTS: Electroretinography showed a "negative" B-wave. Paracentral and central scotomas were observed on Goldmann perimetry. Antibodies to a retinal transducin were demonstrated by Western blotting. No immunoreactivity to retinal bipolar cells was detected by immunohistochemistry.

CONCLUSION: Melanoma-associated retinopathy can be related to a variety of antiretinal antibodies. Recognition of transducin, a novel melanoma-associated retinopathy antigen, may be important for identifying and treating patients with night blindness and melanoma.

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