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The impact and management of Turner's syndrome in adult life.

Turner's syndrome (TS), caused by an absent or structurally abnormal X chromosome, affects 1 in 2500 live female births. Most medical attention has focused on the attainment of final height in childhood and, when this has been achieved, many women are discharged to primary care. It has become increasingly evident that adults with Turner's syndrome are susceptible to a range of disorders such as osteoporosis, hypothyroidism and diabetes. Because of these, and because of the need for long-term oestrogen replacement, it seems most practical for adult health surveillance in TS to come under the remit of the endocrinologist. It must be accepted, however, that the reduced life expectancy in women with TS is largely accounted for by cardiovascular disease. Also, the commonly observed social isolation in adults with TS can be linked to deafness that is increasingly prevalent in an ageing group. Co-ordination of all these issues requires a dedicated multidisciplinary clinic along the lines of those in place in diabetes.

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