[An experimental study of antisense TGF-beta 1 inhibiting keloid fibroblast proliferation in vitro]

Q Shang, R Yuan, W Wang
Zhonghua Zheng Xing Wai Ke za Zhi, Zhonghua Zhengxing Waike Zazhi, Chinese Journal of Plastic Surgery 2001, 17 (6): 325-7

OBJECTIVE: To study the effect of antisense TGF-beta 1 on keloid fibroblast proliferation in vitro.

METHODS: The antisense TGF-beta 1 was transfected into the keloid fibroblast by liposome. The cell count technique was used to test the effect of antisense TGF-beta 1 on keloid fibroblast proliferation in vitro. Cell apoptosis was tested by FCM.

RESULTS: Antisense TGF-beta 1 can inhibit the proliferation of keloid fibroblast in vitro; Antisense TGF-beta 1 can increase the apoptosis ratio of keloid fibroblast in vitro.

CONCLUSIONS: Antisense TGF-beta 1 can induce keloid fibroblast apoptosis and inhibit keloid fibroblast proliferation in vitro, which may contribute to the inhibition of keloid formation in vivo.

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