We have located links that may give you full text access.
[Expression of surviving gene and its relationship with expression of P53, c-myc, k-ras proteins in non-small-cell lung cancer].
OBJECTIVE: To study the expression of surviving and its relationship with expression of P53, c-myc, k-ras in non-small-cell lung cancer (NSCLC).
METHODS: Expression of the surviving mRNA was evaluated by reverse transcriptase polymerase chain reaction (RT-PCR) in 76 NSCLC tumor samples, 20 benign phymatoid lesion and 21 adjacent normal lung tissue samples. Immunohistochemical assay was to detect the expression of P53, c-myc, k-ras proteins.
RESULTS: Expression of surviving gene was detected in a significantly greater proportion of NSCLC (61%) than phymatoid lesion (30%) and adjacent normal lung tissue (19%) (P < 0.001). There was no relationship between surviving gene expression and histologic subtype, differentiation, TNM stages, or lymph node metastases. The expression of surviving gene correlated with P53 or c-myc expression, but not k-ras expression.
CONCLUSION: (1) The up-regulation expression of surviving gene in NSCLC suggested that surviving may play a role in the pathway of carcinogenesis and surviving may be identified as a potential therapeutic target in NSCLC. (2) surviving, de-activation of antioncogene P53 and up-regulation of oncogene c-myc might play synergetic roles in the process of carcinogenesis of NSCLC. But surviving and k-ras may be independently involved in the pathogenesis of lung cancer.
METHODS: Expression of the surviving mRNA was evaluated by reverse transcriptase polymerase chain reaction (RT-PCR) in 76 NSCLC tumor samples, 20 benign phymatoid lesion and 21 adjacent normal lung tissue samples. Immunohistochemical assay was to detect the expression of P53, c-myc, k-ras proteins.
RESULTS: Expression of surviving gene was detected in a significantly greater proportion of NSCLC (61%) than phymatoid lesion (30%) and adjacent normal lung tissue (19%) (P < 0.001). There was no relationship between surviving gene expression and histologic subtype, differentiation, TNM stages, or lymph node metastases. The expression of surviving gene correlated with P53 or c-myc expression, but not k-ras expression.
CONCLUSION: (1) The up-regulation expression of surviving gene in NSCLC suggested that surviving may play a role in the pathway of carcinogenesis and surviving may be identified as a potential therapeutic target in NSCLC. (2) surviving, de-activation of antioncogene P53 and up-regulation of oncogene c-myc might play synergetic roles in the process of carcinogenesis of NSCLC. But surviving and k-ras may be independently involved in the pathogenesis of lung cancer.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app