[The effect of preoperative transcatheter hepatic arterial chemoembolization on disease-free survival after hepatectomy for hepatocellular carcinoma]

Z Zhang, M Wu, Q Liu
Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology] 1999, 21 (3): 214-6

OBJECTIVE: To analyse the effect of preoperative transcatheter hepatic arterial chemoembolization(TACE) on disease-free survival rate after surgical excision for hepatocellular carcinoma(HCC), in order to evaluate its therapeutic significance.

METHODS: The history of 1,457 cases of HCC with long term follow-up who received curative or relatively curative tumor resection was reviewed. Among these patients, 120 received preoperative TACE. Factors of prognostic significance were analysed using Cox proportional hazards survival mode, and the disease-free survival was analysed by Kaplan-Meier estimation.

RESULTS: Multivariate analysis revealed that the factors of prognostic significance were number and size of tumor mass and its gross type, number and efficacy of TACE treatment, presence of tumor thrombus, satellite nodules, vascular invasion, and postoperative AFP level. The 5-year disease-free survival rate following surgery of patients who received TACE twice or more was 51.0%, while that of patients who received TACE once and none was 35.5% and 21.4%, respectively. The mean disease-free suvival time in these 3 groups of patients was 66.4, 22.5 and 12.5 months, respectively. For patients whose TACE treatment was effective, the 5-year disease-free survival rate was 56.8%, with a mean disease-free suvival time of 90.1 months.

CONCLUSION: Preoperative TACE is so far the most feasible approach to improve disease-free survival of HCC patients.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"