Recombinant tissue plasminogen activator in the treatment of central venous catheter occlusion in children

B R Jacobs, M Haygood, J Hingl
Journal of Pediatrics 2001, 139 (4): 593-6
Tissue plasminogen activator was used to treat 228 children with 320 central venous catheter (CVC) occlusion events. Patency was restored in 91% of CVCs after 1 to 3 treatments, with no adverse events. Tissue plasminogen activator is effective in restoring patency to occluded CVCs and is a viable alternative to CVC removal or urokinase treatment.

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