We have located links that may give you full text access.
COMPARATIVE STUDY
JOURNAL ARTICLE
Repeated antenatal corticosteroid treatments. Do they reduce neonatal morbidity?
Journal of Reproductive Medicine 2001 September
OBJECTIVE: To compare the effectiveness of single, as compared to multiple, courses of antenatal steroid treatments in reducing neonatal morbidity.
STUDY DESIGN: A retrospective chart review of 204 patients who delivered preterm and received antenatal corticosteroids between June 1996 and December 1998 was performed and data extracted. All patients who delivered prior to 35 weeks of gestation and received corticosteroids were included. The number of antenatal treatments was chosen by the obstetrician caring for the patient as well as by the opportunity to administer steroids.
RESULTS: There were 61 patients in the multiple-course group. Gestational age was greater in the multiple-course group (31.6 vs. 30.6, P = 0.3), but Apgar scores, neonatal hospital stay, specific neonatal morbidity and combined morbidity were not different between the two groups. Combined neonatal morbidity was higher after three courses of antenatal steroids (29% vs. 50%). Logistic regression analyses adjusting for gestational age suggest a possible adverse effect of multiple courses, development of respiratory distress syndrome (odds ratio 1.3; confidence interval 1.02; 1.8; P = .02) and combined neonatal morbidity (odds ratio 1.3; confidence interval 1.04; 1.7; P = .02).
CONCLUSION: Weekly antenatal steroids do not improve neonatal morbidity.
STUDY DESIGN: A retrospective chart review of 204 patients who delivered preterm and received antenatal corticosteroids between June 1996 and December 1998 was performed and data extracted. All patients who delivered prior to 35 weeks of gestation and received corticosteroids were included. The number of antenatal treatments was chosen by the obstetrician caring for the patient as well as by the opportunity to administer steroids.
RESULTS: There were 61 patients in the multiple-course group. Gestational age was greater in the multiple-course group (31.6 vs. 30.6, P = 0.3), but Apgar scores, neonatal hospital stay, specific neonatal morbidity and combined morbidity were not different between the two groups. Combined neonatal morbidity was higher after three courses of antenatal steroids (29% vs. 50%). Logistic regression analyses adjusting for gestational age suggest a possible adverse effect of multiple courses, development of respiratory distress syndrome (odds ratio 1.3; confidence interval 1.02; 1.8; P = .02) and combined neonatal morbidity (odds ratio 1.3; confidence interval 1.04; 1.7; P = .02).
CONCLUSION: Weekly antenatal steroids do not improve neonatal morbidity.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
The Effect of Albumin Administration in Critically Ill Patients: A Retrospective Single-Center Analysis.Critical Care Medicine 2024 Februrary 8
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app