Extra copies of chromosomes 7, 8, 12, 19, and 21 are recurrent in adamantinoma

M Kanamori, C R Antonescu, M Scott, R S Bridge, J R Neff, S S Spanier, M T Scarborough, G Vergara, H G Rosenthal, J A Bridge
Journal of Molecular Diagnostics: JMD 2001, 3 (1): 16-21
Adamantinoma of long bones is a rare neoplasm predominantly involving the tibia. Cytogenetic studies of adamantinoma are few. Cytogenetic or molecular cytogenetic analysis of four adamantinomas, and a review of eleven cases in the literature reveals extra copies of chromosomes 7, 8, 12, 19, and 21 as recurrent in this neoplasm. Adamantinoma may be confused with a variety of primary and metastatic epithelial and mesenchymal neoplasms. Observation of these aneuploidies may be useful in establishing the diagnosis of adamantinoma.

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