We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Postsynaptic origin of N-methyl-D-aspartate-induced slow currents in substantia gelatinosa neurons: an in vitro voltage-clamp study in adult rat.
Neuroscience Letters 2000 September 30
We investigated whether N-methyl-D-aspartate (NMDA)-induced slow current in substantia gelatinosa (SG) neurons might be of presynaptic or postsynaptic origin. Whole-cell voltage-clamp recordings were made from adult rat spinal cord slices to examine the effect of NMDA receptor upon miniature excitatory postsynaptic currents (mEPSCs) in SG neurons. At a holding potential of -70 mV, bath application of NMDA (10 microM, 30s), an NMDA receptor agonist, affected neither the frequency nor the mean amplitude of mEPSCs, while NMDA induced a slow excitatory membrane current which persisted in the presence of tetrodotoxin. On the other hand, AP-5 (an NMDA receptor antagonist) had no noticeable effects on mEPSCs in the SG neurons tested, while it markedly depressed the NMDA-induced slow currents. The NMDA-induced slow currents varied with the changing of holding potentials (from -70 to 0 mV). The results suggested that the NMDA-induced slow currents in SG neurons were of postsynaptic origin.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app