Light chain deposition disease neuropathy resembling amyloid neuropathy in a multiple myeloma patient

M P Grassi, F Clerici, C Perin, M Borella, A Gendarini, A Quattrini, R Nemni, A Mangoni
Italian Journal of Neurological Sciences 1998, 19 (4): 229-33
A 65-year-old man with IgG lambda multiple myeloma developed severe polyneuropathy with prominent thermal-pain sensory impairment and autonomic failure. Although the clinical presentation suggested amyloid neuropathy, nerve biopsy showed the immunohistochemical and ultrastructural features typical of light chain deposition disease (LCDD). A precise morphologic and clinical description of LCDD neuropathy is given for the first time in the present report.

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