[Expression of endothelial nitric oxide synthase gene in placental villus of preeclampsia]

X Tong, S Li, Y Zhao
Zhonghua Fu Chan Ke za Zhi 1998, 33 (9): 527-8

OBJECTIVE: To investigate the expression of endothelia nitric oxide synthase (eNOS) mRNA in the villus of preeclampsia and the relationship between eNOS and preeclampsia.

METHODS: Dot blot, using DIG-labeled human eNOS cDNA probe, had been used to examine the expression of eNOS gene in placental tissues of 9 normotensive pregnancy and 9 preeclampsia women. By using Leica QWIN image disposal and analysis system Mean OD of every dot was assessed.

RESULTS: The level of eNOS mRNA in placental villus was significantly lower in preeclampsia woman than that of control group (P < 0.001).

CONCLUSION: The decrease of eNOS in placental villus of preeclampsia may be one of the causes for human placental dysfunction and high impedance of fetoplacental circulation in preeclampsia. It may play an improtant role in the genesis of pregnancy induced hypertension.

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