We have located links that may give you full text access.
Monitoring of a film coating process for tablets using near infrared reflectance spectrometry.
A process analytical chemical method using near infrared diffuse reflectance spectrometry was developed for the determination of the amount of tablet coating on single tablets. This method is based on calibration of the spectra versus the added mass of coating solution. The tablet core was composed of two halves of different chemical composition and spectra were recorded from both sides of the tablets. The calibration was carried out using the chemometric methods principal component analysis (PCA), partial least squares (PLS), and multiplicative signal correction (MSC). The PLS-model utilised spectra obtained from both sides, pretreated with MSC, and ordered into one object. This method can be used in process analytical chemistry at-line. Additional characterisation of the measurements was obtained by calibrating the spectra versus coating thicknesses obtained from optical microscopy. Using PCA, it was possible to roughly estimate the maximum depth in the coating material that returns chemical information, the 'information depth', which was 0.1-0.2 mm.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app