Role of brain biopsy in the management of focal brain lesions in HIV-infected patients. Gruppo Italiano Cooperativo AIDS & Tumori

A Antinori, A Ammassari, R Luzzati, A Castagna, R Maserati, G Rizzardini, A Ridolfo, M Fasan, E Vaccher, G Landonio, M Scerrati, A Rocca, G Butti, A Nicolato, A Lazzarin, U Tirelli
Neurology 2000 February 22, 54 (4): 993-7
In this multicenter, retrospective study of 160 brain biopsies in the assessment of HIV-related focal brain lesions, diagnostic sensitivity was acceptable (87%), but the procedure carried considerable morbidity (7.5%) and mortality (3.1%). Moreover, it is not always possible to initiate the changes in therapy indicated by the results, and overall survival remains poor, with a median of 2 months. Criteria for brain biopsy for the diagnosis of focal brain lesions should be redefined to include selected patients for whom a less invasive approach does not yield a definitive diagnosis.

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