JOURNAL ARTICLE
RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
Add like
Add dislike
Add to saved papers

Does osteocyte formation cause the nonlinear refilling of osteons?

Bone 2000 January
Marotti (Ital J Anat Embryol 1 01:25-79, 1996) described a theory of osteocyte differentiation from osteoblasts during bone formation. This theory postulates that, when a previously formed osteocyte is sufficiently covered by new bone and osteoid, it sends an inhibitory signal through its dendritic processes to the neighboring osteoblasts that reduces their individual apposition rates. The osteoblast most affected by this inhibition becomes buried by its neighbors, and becomes one of the next layer of osteocytes. By pursuing this concept, the present study develops a mathematical theory that predicts another observation about bone remodeling: the diminishment of the apposition rate during the refilling of basic multicellular units (BMUs). This decrease in apposition rate is different in osteonal and surface (e.g., trabecular) BMUs, and the theory shows that this result is consistent with the accrual of osteocyte inhibition throughout the refilling period, with the different ratios of bone volume to surface area in these two types of BMUs.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app