SupportLoginSign Up
Featured FeedJournalsCollectionsKeywords
COMPARATIVE STUDY
JOURNAL ARTICLE
RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
Add like
Add dislike
Add to saved papers

Decreased interstitial cell of cajal volume in patients with slow-transit constipation.

C L He, L Burgart, L Wang, J Pemberton, T Young-Fadok, J Szurszewski, G Farrugia
Gastroenterology 2000 January
BACKGROUND & AIMS: The cause of slow-transit constipation is incompletely understood. Recent observations suggest a central role for interstitial cells of Cajal in the control of intestinal motility. The aim of this study was to determine the volume of interstitial cells of Cajal in the normal sigmoid colon and in the sigmoid colon from patients with slow transit constipation.

METHODS: Sigmoid colonic samples were stained with antibodies to protein gene product 9.5, c-Kit, and alpha-smooth muscle actin. Three-dimensional reconstruction of regions of interest was performed using consecutive images collected on a laser scanning confocal microscope and ANALYZE software.

RESULTS: Volume of interstitial cells of Cajal was significantly decreased in all layers of sigmoid colonic specimens from patients with slow-transit constipation compared with normal controls. Neuronal structures within the colonic circular smooth muscle layer were also decreased.

CONCLUSIONS: A decrease in the volume of interstitial cells of Cajal may play an important role in the pathophysiology of slow-transit constipation.

Full text links

Find Full Text Links for this Article

Trending Papers

Narrative Review: Low-Dose Ketamine for Pain Management.Alessandro Riccardi et al.Journal of Clinical Medicine 2023 May 3
How to improve the efficiency and the safety of real-time ultrasound-guided central venous catheterization in 2023: a narrative review.N Boulet et al.Annals of Intensive Care 2023 May 26
Corticosteroids in ARDS.Emmanuelle Kuperminc et al.Journal of Clinical Medicine 2023 May 9
SGLT2 Inhibitors: A New Therapeutical Strategy to Improve Clinical Outcomes in Patients with Chronic Kidney Diseases.Assunta Di Costanzo et al.International Journal of Molecular Sciences 2023 May 14
Dilemma of immunosuppression and infection risk in systemic lupus erythematosus.Jing He, Zhanguo LiRheumatology 2023 March 30
A practical approach to in-hospital management of new-onset refractory status epilepticus/febrile infection related epilepsy syndrome.Zubeda Sheikh, Lawrence J HirschFrontiers in Neurology 2023

For the best experience, use the Read mobile app

Group 7SearchHeart failure treatmentPapersTopicsCollectionsEffects of Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Patients With Heart Failure Importance: Only 1 class of glucose-lowering agents-sodium-glucose cotransporter 2 (SGLT2) inhibitors-has been reported to decrease the risk of cardiovascular events primarily by reducingSeptember 1, 2017: JAMA CardiologyAssociations of albuminuria in patients with chronic heart failure: findings in the ALiskiren Observation of heart Failure Treatment study.CONCLUSIONS: Increased UACR is common in patients with heart failure, including non-diabetics. Urinary albumin creatininineJul, 2011: European Journal of Heart FailureRandomized Controlled TrialEffects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.Review

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

Do Not Sell My Personal InformationManage Cookie Preferences

Read by QxMD is copyright © 2021 QxMD Software Inc. All rights reserved. By using this service, you agree to our terms of use and privacy policy.

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app