Unilateral angiolymphoid hyperplasia with eosinophilia involving the left arm and hand

M Arnold, C C Geilen, S E Coupland, S Krengel, E Dippel, J Spröder, S Goerdt, C E Orfanos
Journal of Cutaneous Pathology 1999, 26 (9): 436-40
A case report of recurrent angiolymphoid hyperplasia with eosinophilia (ALHE) in an otherwise healthy 20-year-old female with manifestation of the disease limited to the left arm and hand is presented together with brief evaluation of the literature as well as the features distinguishing ALHE and Kimura's disease. Immunohistochemical investigations support the hypothesis that ALHE represents a reactive inflammatory lesion rather than a benign vascular neoplasm. A viral cause of ALHE (e.g., HHV8 or Epstein-Barr virus (EBV)) could not be demonstrated. The recurrent nature of the disease is shown by this case, which also demonstrates the need for frequent medical and surgical management.

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