JOURNAL ARTICLE

Coordinated polar localization of auxin efflux carrier PIN1 by GNOM ARF GEF

T Steinmann, N Geldner, M Grebe, S Mangold, C L Jackson, S Paris, L Gälweiler, K Palme, G Jürgens
Science 1999 October 8, 286 (5438): 316-8
10514379
The plant hormone auxin is transported in a polar manner along the shoot-root axis, which requires efflux carriers such as PIN1. Asymmetric localization of PIN1 develops from a random distribution in Arabidopsis early embryogenesis. Coordinated polar localization of PIN1 is defective in gnom embryos. GNOM is a membrane-associated guanine-nucleotide exchange factor on ADP-ribosylation factor G protein (ARF GEF). Thus, GNOM-dependent vesicle trafficking may establish cell polarity, resulting in polar auxin transport.

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