JOURNAL ARTICLE
REVIEW

Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review

K M Wyatt, P W Dimmock, P W Jones, P M Shaughn O'Brien
BMJ: British Medical Journal 1999 May 22, 318 (7195): 1375-81
10334745

OBJECTIVE: To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome.

DESIGN: Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome.

SUBJECTS: Nine published trials representing 940 patients with premenstrual syndrome.

MAIN OUTCOME MEASURES: Proportion of women whose overall premenstrual symptoms showed an improvement over placebo. A secondary analysis was performed on the proportion of women whose premenstrual depressive symptoms showed an improvement over placebo.

RESULTS: Odds ratio relative to placebo for an improvement in overall premenstrual symptoms was 2.32 (95% confidence interval 1.95 to 2.54). Odds ratio relative to placebo for an improvement in depressive symptoms was 1.69 (1.39 to 2.06) from four trials representing 541 patients.

CONCLUSION: Conclusions are limited by the low quality of most of the trials included. Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression.

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