JOURNAL ARTICLE
RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
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Rapid recovery of bone mass in hypercalciuric, osteoporotic men treated with hydrochlorothiazide.

BACKGROUND: Chronic hypercalciuria can contribute to osteoporosis, particularly in men.

OBJECTIVE: To ascertain the effects of resolution of hypercalciuria on bone mineral density.

DESIGN: Case series.

SETTING: Referral service for metabolic bone disease in a tertiary-care teaching hospital.

PATIENTS: Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis.

INTERVENTION: Hydrochlorothiazide, 25 mg twice daily, for a mean (+/- SD) of 7.8 +/- 3.6 months.

MEASUREMENTS: Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration.

RESULTS: Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively.

CONCLUSIONS: Hydrochlorothiazide treatment in hypercalciuric and osteoporotic men was associated with a rapid rebound increase in bone mineral density.

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