JOURNAL ARTICLE
Add like
Add dislike
Add to saved papers

Carbon monoxide poisoning treated with hyperbaric oxygen: metabolic acidosis as a predictor of treatment requirements.

A retrospective case note analysis was made of patients who received hyperbaric oxygen for carbon monoxide poisoning and were admitted to the Royal Naval Hospital Haslar between 1991 and 1995. Males predominated (38 v 10) as did cases of deliberate self poisoning (31 v 17). The most common presenting feature was unconsciousness, which is an indication for hyperbaric oxygen and therefore reflects referral patterns. If patients had not recovered completely after one hyperbaric exposure further treatments were given. The initial hydrogen ion concentration of those requiring more than one treatment was significantly higher than those who recovered after the first treatment. The initial carboxyhaemoglobin (COHb) concentration showed only a trend to being higher in the multiple treatment group. Although metabolic acidosis is well recognised, its relationship to treatment requirements has not been shown previously. Initial COHb does not always correlate well with severity of poisoning which relates to the mechanism of toxicity of carbon monoxide: binding of carbon monoxide to the intracellular oxygen carrying proteins (for example cytochromes) rather than solely to haemoglobin. These findings are consistent with this mechanism and suggests that initial acidosis is a better predictor of treatment requirements and severity than initial COHb.

Full text links

For the best experience, use the Read mobile app

Group 7SearchHeart failure treatmentPapersTopicsCollectionsEffects of Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Patients With Heart Failure Importance: Only 1 class of glucose-lowering agents-sodium-glucose cotransporter 2 (SGLT2) inhibitors-has been reported to decrease the risk of cardiovascular events primarily by reducingSeptember 1, 2017: JAMA CardiologyAssociations of albuminuria in patients with chronic heart failure: findings in the ALiskiren Observation of heart Failure Treatment study.CONCLUSIONS: Increased UACR is common in patients with heart failure, including non-diabetics. Urinary albumin creatininineJul, 2011: European Journal of Heart FailureRandomized Controlled TrialEffects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.Review

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

Read by QxMD is copyright © 2021 QxMD Software Inc. All rights reserved. By using this service, you agree to our terms of use and privacy policy.

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app