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COMPARATIVE STUDY
JOURNAL ARTICLE
Comparison of prognostic significance of nodal staging between old (4th edition) and new (5th edition) UICC TNM classification for gastric carcinoma. International Union Against Cancer.
World Journal of Surgery 1999 May
The description of nodal staging for gastric cancer was changed in the new fifth edition of the International Union Against Cancer (UICC) TNM classification from the anatomic sites of metastatic lymph nodes to the number of metastatic lymph nodes, as pN1 is metastasis in 1 to 6 lymph nodes, pN2 is in 7 to 15 lymph nodes, and pN3 is in 16 or more lymph nodes. The purpose of this study was to investigate the prognostic significance of the new staging system based on the number of metastatic lymph nodes compared to the old staging system by anatomic site. From 1987 to 1994 a total of 2108 patients who underwent potentially curative resections with D2 or D3 lymph node dissection and with 15 or more lymph nodes retrieved were studied retrospectively. Lymph node metastases were found in 1018 patients (48.3%). A mean of 37.9 lymph nodes were retrieved per patient, and a mean of 7.2 lymph nodes were invaded by tumor cells. We found that the new nodal staging based on the number of metastatic lymph nodes closely correlated with the depth of cancer invasion and with the old nodal staging based on the anatomic site of the metastatic nodes, with statistical significance. The 5-year survival rates after gastrectomy decreased significantly by increasing the extent of the pN classification in both nodal staging methods. In a subgroup analysis of survivals between the old and new nodal staging, the new classification showed more homogeneous survival at the same stage than the old one. With a multivariate analysis of prognostic factors, including the old and new nodal staging, the depth of invasion and the new nodal stage were the most significant prognostic factors, followed by the old nodal stage. Our data suggested that the new nodal staging based on the number of metastatic lymph nodes is not only a reliable and objective method for nodal classification, but it is also a significant prognostic determinant for gastric cancer that can be used in practice.
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