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JOURNAL ARTICLE

Parallel synthesis of 1,2,4-oxadiazoles using CDI activation

T L Deegan, T J Nitz, D Cebzanov, D E Pufko, J A Porco
Bioorganic & Medicinal Chemistry Letters 1999 January 18, 9 (2): 209-12
10021930
1,2,4-Oxadiazoles have been prepared in parallel using 1,1'-carbonyldiimidazole (CDI) as a reagent for both formation and cyclodehydration of O-acyl benzamidoximes. The use of CDI facilitates parallel purification of the oxadiazole products by simple liquid-liquid extraction and filtration.

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