Tobias Ruck, Stefanie Bock, Steffen Pfeuffer, Christina B Schroeter, Derya Cengiz, Paul Marciniak, Maren Lindner, Alexander Herrmann, Marie Liebmann, Stjepana Kovac, Lukas Gola, Leoni Rolfes, Marc Pawlitzki, Nils Opel, Tim Hahn, Udo Dannlowski, Thomas Pap, Felix Luessi, Julian A Schreiber, Bernhard Wünsch, Tanja Kuhlmann, Guiscard Seebohm, Björn Tackenberg, Patricia Seja, Frank Döring, Erhard Wischmeyer, Achmet Imam Chasan, Johannes Roth, Luisa Klotz, Gerd Meyer Zu Hörste, Heinz Wiendl, Tobias Marschall, Stefan Floess, Jochen Huehn, Thomas Budde, Tobias Bopp, Stefan Bittner, Sven G Meuth
It remains largely unclear how thymocytes translate relative differences in T cell receptor (TCR) signal strength into distinct developmental programs that drive the cell fate decisions towards conventional (Tconv) or regulatory T cells (Treg). Following TCR activation, intracellular calcium (Ca2+ ) is the most important second messenger, for which the potassium channel K2P 18.1 is a relevant regulator. Here, we identify K2P 18.1 as a central translator of the TCR signal into the thymus-derived Treg (tTreg) selection process...
January 2022: Cell Research