Qin Sun, Xiaorui Xing, Huanyu Wang, Kang Wan, Ruobing Fan, Cheng Liu, Yongjian Wang, Wenyi Wu, Yibing Wang, Ru Wang
Metabolic diseases, featured with dysregulated energy homeostasis, have become major global health challenges. Patients with metabolic diseases have high probability to manifest multiple complications in lipid metabolism, e.g. obesity, insulin resistance and fatty liver. Therefore, targeting the hub genes in lipid metabolism may systemically ameliorate the metabolic diseases, along with the complications. Stearoyl-CoA desaturase 1(SCD1) is a key enzyme that desaturates the saturated fatty acids (SFAs) derived from de novo lipogenesis or diet to generate monounsaturated fatty acids (MUFAs)...
November 30, 2023: Biomedicine & Pharmacotherapy