Alastair Carruthers, Jean Carruthers, William P Coleman, Lisa Donofrio, Timothy Flynn, Michael Gold, Moritz Heinz, Laura Harrington, Derek Jones, David McDaniel, Thomas Rohrer, Andrea Schlöbe, Nowell Solish, Robert A Weiss
BACKGROUND: Botulinum toxin type A is a proven, effective aesthetic treatment for glabellar frown lines. IncobotulinumtoxinA (NT 201, Xeomin/Xeomeen/Bocouture, Merz Pharmaceuticals GmbH, Frankfurt, Germany) is a 150-kDa botulinum toxin type A free of complexing proteins. OBJECTIVE: To assess the efficacy and safety of incobotulinumtoxinA in a randomized, double-blind, placebo-controlled, Phase III study in patients with moderate to severe glabellar frown lines. MATERIALS AND METHODS: Two hundred seventy-six patients were randomized 2:1 to receive a single injection of 20 U of incobotulinumtoxinA or placebo, respectively...
April 2013: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]