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JOURNAL ARTICLE
Gyoohwan Jung, Jung Kwon Kim, Jong Jin Oh, Sangchul Lee, Seok-Soo Byun, Sung Kyu Hong, Hakmin Lee
BACKGROUND: We compared the clinical outcomes of robot-assisted radical prostatectomy (RARP) and partial gland ablation (PGA) using high-intensity focused ultrasound (HIFU) in localized prostate cancer. METHODS: We analyzed 3,859 patients who had undergone RARP and PGA using HIFU. According to the propensity score for each treatment, 137 patients after PGA were matched to 3,722 patients after RARP at a 1:4 ratio using the nearest neighbor method. RESULTS: The matched cohort comprised 685 subjects (RARP, 548; PGA, 137), with a median follow-up period of 22 months...
September 2023: Prostate International
#22
JOURNAL ARTICLE
Mu Yao Tsai, Chih Tai Lin, Ping Hsuan Chiang, Po Hui Chiang, Ping Chia Chiang
PURPOSE: We reported preliminary outcomes of high-intensity focused ultrasound (HIFU) [Sonablate® ] in the combination of transurethral resection of the prostate for localized prostate cancer in Taiwan. METHODS: Seventy-seven patients using Sonablate® HIFU for localized prostate cancer were enrolled in this study from April 2021 to December 2022. Prostate-specific antigen biochemical recurrence, International Index of Erectile Function (IIEF)-5 scores, International Prostate Symptom Score (IPSS), quality of life (QoL) scores, and postoperative complications were recorded during follow-up...
September 11, 2023: Annals of Surgical Oncology
#23
Alexander Hwang, Matthew Watson, Sriharsha Talluri, Henry Okafor, Amar Singh
OBJECTIVE: We aim to introduce the application of the perivesical fat rotational flap as a substitute for omental interposition during several complex urologic reconstruction. We highlight our technique using a case of salvage prostatectomy after initial high intensity focused ultrasound (HIFU) for recurrent high risk prostate cancer requiring future adjuvant radiation treatment. We have also successfully used this technique in the management of recurrent vesicovaginal, colovesical, rectourethral fistulas, and post radiation salvage prostatectomy setting...
September 8, 2023: Urology
#24
JOURNAL ARTICLE
Deepika Reddy, Marieke van Son, Max Peters, Mariana Bertoncelli Tanaka, Tim Dudderidge, Emma Cullen, Carmen Lok Tung Ho, Richard G Hindley, Amr Emara, Stuart McCracken, Clement Orczyk, Iqbal Shergill, Stephen Mangar, Raj Nigam, Jaspal Virdi, Caroline M Moore, Manit Arya, Taimur T Shah, Mathias Winkler, Mark Emberton, Alison Falconer, Jonathan Belsey, Hashim U Ahmed
AIMS: Focal therapy treats individual areas of tumour in non-metastatic prostate cancer in patients unsuitable for active surveillance. The aim of this work was to evaluate the cost-effectiveness of focal therapy versus prostatectomy and external beam radiotherapy (EBRT). MATERIALS AND METHODS: A Markov cohort health state transition model with four health states (stable disease, local recurrence, metastatic disease and death) was created, evaluating costs and utilities over a 10-year time horizon for patients diagnosed with non-metastatic prostate cancer...
2023: Journal of Medical Economics
#25
REVIEW
Mara Carsote, Dana Terzea, Florina Vasilescu, Anca-Pati Cucu, Adrian Ciuche, Claudiu Nistor
We aimed to overview the most recent data on sternal metastases from a multidisciplinary approach (diagnosis strategies, outcome, and histological reports). This narrative review based on a PubMed search (between January 2020 and 22 July 2023) using key words such as "sternal", "manubrium", and "metastasis" within the title and/or abstract only included original papers that specifically addressed secondary sternal spreading of cancer in adults, for a total of 48 original articles (14 studies and 34 single case reports)...
August 17, 2023: Diagnostics
#26
JOURNAL ARTICLE
Sabrina De Cillis, Nadir Osman, Cyrille Guillot-Tantay, Francois Hervé, Mikolaj Przydacz, Manuela Tutolo, Gokhan Culha, Paolo Geretto, Fabiana Cancrini, Enrico Checcucci, Veronique Phé
PURPOSE OF REVIEW: The aim of this narrative review is to evaluate the current available literature on urinary outcomes following cryotherapy and high-intensity focused ultrasound (HIFU) for localized prostate cancer (PCa). RECENT FINDINGS: The available literature is heterogeneous in terms of intervention modalities and assessment of urinary outcome measures. Nevertheless, ultra-minimally invasive treatments seem to provide good urinary outcomes. Technological advancement and the adoption of more conservative ablation templates allow for a further reduction of toxicity and better preservation of urinary function...
November 1, 2023: Current Opinion in Urology
#27
JOURNAL ARTICLE
Aurore Mattlet, Ksenija Limani, Peltier Alexandre, Eric Hawaux, Rawad Abou Zahr, Fouad Aoun, Romain Diamand
PURPOSE: This is an external validation of several biochemical recurrence definitions based on prostate specific antigen criteria (PSA). The purpose is to predict the need of additional treatment and failure after focal therapy using high intensity focused ultrasound (HIFU) for localized prostate cancer (PCa). MATERIALS AND METHODS: A total of 343 consecutive patients who underwent HIFU with Ablatherm® and Focal One® devices between June 2001 and November 2020 were identified...
August 13, 2023: Prostate
#28
JOURNAL ARTICLE
Ivan M Suarez-Castellanos, Geoffroy De Sallmard, Guillaume Vanstaevel, Alice Ganeau, Christopher Bawiec, Jean-Yves Chapelon, Nicolas Guillen, Nicolas Senegond, W Apoutou N'Djin
Thermal ablation of localized prostate tumors via endocavitary Ultrasound-guided High Intensity Focused Ultrasound (USgHIFU) faces challenges that could be alleviated by better integration of dual modalities (imaging/therapy). Capacitive Micromachined Ultrasound Transducers (CMUTs) may provide an alternative to existing piezoelectric technologies by exhibiting advanced integration capability through miniaturization, broad frequency bandwidth and potential for high electro-acoustic efficiency. An endocavitary dual-mode USgHIFU probe was built to investigate the potential of using CMUT technologies for transrectal prostate cancer ablative therapy...
August 4, 2023: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
#29
REVIEW
Rossella Nicoletti, Andrea Alberti, Daniele Castellani, Chi Hang Yee, Kai Zhang, Darren M C Poon, Peter Ka-Fung Chiu, Riccardo Campi, Giulio Raffaele Resta, Edoardo Dibilio, Giacomo Maria Pirola, Giuseppe Chiacchio, Demetra Fuligni, Carlo Brocca, Carlo Giulioni, Virgilio De Stefano, Sergio Serni, Vineet Gauhar, Chi Fai Ng, Mauro Gacci, Jeremy Yuen Chun Teoh
INTRODUCTION: Focal therapy (FT) is a promising alternative to whole-gland treatments for Localized Prostate Cancer. Ten different FT modalities have been described in literature. However, FT is not yet recommended by the International Guidelines, due to the lack of robust data on Oncological Outcomes. The objective of our Narrative Review is to evaluate the oncological profile of the available FT modalities and to offer a comprehensive overview of the definitions of Cancer Control for FT...
July 28, 2023: Prostate Cancer and Prostatic Diseases
#30
JOURNAL ARTICLE
Matthew G Parry, Arunan Sujenthiran, Julie Nossiter, Melanie Morris, Brendan Berry, Arjun Nathan, Ajay Aggarwal, Heather Payne, Jan van der Meulen, Noel W Clarke
OBJECTIVES: To report the 5-year failure-free survival (FFS) following HIFU. METHODS: This observational cohort study used linked national cancer registry data, radiotherapy data, administrative hospital data and mortality records of 1,381 men treated with HIFU for clinically localised prostate cancer in England. The primary outcome, FFS, was defined as freedom from local salvage treatment and cancer-specific mortality. Secondary outcomes were freedom from repeat HIFU, prostate cancer-specific survival (CSS) and overall survival (OS)...
July 8, 2023: BJU International
#31
REVIEW
Sriram Deivasigamani, Srinath Kotamarti, Ardeshir R Rastinehad, Rafael Sanchez Salas, J J M C H de la Rosette, Herbert Lepor, Peter Pinto, Hashim U Ahmed, Inderbir Gill, Laurence Klotz, Samir S Taneja, Mark Emberton, Nathan Lawrentschuk, James Wysock, John F Feller, Sebastien Crouzet, Praveen Kumar M, Denis Seguier, Eric S Adams, Zoe Michael, Andre Abreu, Kae Jack Tay, John F Ward, Katsuto Shinohara, Aaron E Katz, Arnauld Villers, Joseph L Chin, Phillip D Stricker, Eduard Baco, Petr Macek, Ardalan E Ahmad, Peter K F Chiu, E David Crawford, Craig G Rogers, Jurgen J Futterer, Soroush Rais-Bahrami, Cary N Robertson, Boris Hadaschik, Giancarlo Marra, Massimo Valerio, Kian Tai Chong, Veeru Kasivisvanathan, Wei Phin Tan, Derek Lomas, Jochen Walz, Gustavo Cardoso Guimaraes, Nikos I Mertziotis, Ezequiel Becher, Antonio Finelli, Ali Kasraeian, Amir H Lebastchi, Anup Vora, Mark A Rosen, Baris Bakir, Rohit Arcot, Samuel Yee, Christopher Netsch, Xiaosong Meng, Theo M de Reijke, Yu Guang Tan, Stefano Regusci, Tavya G R Benjamin, Ruben Olivares, Mohamed Noureldin, Fernando J Bianco, Arjun Sivaraman, Fernando J Kim, Robert W Given, Shawn Dason, Tyler J Sheetz, Sunao Shoji, Ariel Schulman, Peter Royce, Taimur T Shah, Stephen Scionti, Georg Salomon, Pilar Laguna, Rafael Tourinho-Barbosa, Alireza Aminsharifi, Xavier Cathelineau, Paolo Gontero, Armando Stabile, Jeremy Grummet, Leila Ledbetter, Margaret Graton, J Stephen Jones, Thomas J Polascik
CONTEXT: Whole-gland ablation is a feasible and effective minimally invasive treatment for localized prostate cancer (PCa). Previous systematic reviews supported evidence for favorable functional outcomes, but oncological outcomes were inconclusive owing to limited follow-up. OBJECTIVE: To evaluate the real-world data on the mid- to long-term oncological and functional outcomes of whole-gland cryoablation and high-intensity focused ultrasound (HIFU) in patients with clinically localized PCa, and to provide expert recommendations and commentary on these findings...
December 2023: European Urology
#32
JOURNAL ARTICLE
Lauren M Andring, Bin S Teh, Edward Brian Butler, Andrew M Farach
BACKGROUND AND OBJECTIVE: Prostate cancer is the second most common cause of cancer in men worldwide. A significant proportion of patients will develop biochemical failure after definitive radiotherapy and an increasing number of local failures are now identifiable with prostate specific membrane antigen (PSMA) positron emission tomography and computerized tomography (PET/CT). Brachytherapy (BT) represents an excellent option for definitive local salvage treatment. Consensus guidelines for the delivery of salvage BT are heterogenous and limited...
June 2023: Chinese Clinical Oncology
#33
REVIEW
Hyungwoo Ahn, Sung Il Hwang, Hak Jong Lee, Sang Youn Kim, Jeong Yeon Cho, Hakmin Lee, Sung Kyu Hong, Seok-Soo Byun, Taek Min Kim
PURPOSE: This article aims to evaluate the pooled diagnostic performance control MRI for prediction of recurrent prostate cancer (PCa) after high-intensity focused ultrasound (HIFU). MATERIALS AND METHODS: MEDLINE, EMBASE, and Cochrane library databases up to December 31, 2021, were searched. We included studies providing 2×2 contingency table for diagnostic performance of MRI in predicting recurrent PCa after HIFU, using control biopsy as reference standard...
June 2023: Prostate International
#34
JOURNAL ARTICLE
A V Govorov, A O Vasilyev, A I Alaverdyan, K B Kolontarev, D Y Pushkar
INTRODUCTION: Prostate cancer (PCa) is the second most commonly diagnosed malignant tumor in men after lung cancer and is the fifth leading cause of death worldwide. In November 2019, the spectrum of alternative treatment for PCa was added by a novel minimally invasive method, namely high-intensity focused ultrasound (HIFU) using the latest Focal One machine (with the possibility of combining intraoperative ultrasound and preoperative MRI data). MATERIALS AND METHODS: During the period from November 2019 to November 2021, HIFU using Focal One device (manufactured by EDAP, France) was performed in 75 patients with PCa...
May 2023: Urologii︠a︡
#35
JOURNAL ARTICLE
Alexander Light, Max Peters, Deepika Reddy, Abi Kanthabalan, Marjorie Otieno, Menelaos Pavlou, Rumana Omar, Sola Adeleke, Francesco Giganti, Chris Brew-Graves, Norman R Williams, Amr Emara, Athar Haroon, Arash Latifoltojar, Harbir Sidhu, Alex Freeman, Clement Orczyk, Ashok Nikapota, Tim Dudderidge, Richard G Hindley, Jaspal Virdi, Manit Arya, Heather Payne, Anita V Mitra, Jamshed Bomanji, Mathias Winkler, Gail Horan, Caroline Moore, Mark Emberton, Shonit Punwani, Hashim U Ahmed, Taimur T Shah
OBJECTIVES: To externally validate a published model predicting failure within 2 years after salvage focal ablation in men with localised radiorecurrent prostate cancer using a prospective, UK multicentre dataset. PATIENTS AND METHODS: Patients with biopsy-confirmed ≤T3bN0M0 cancer after previous external beam radiotherapy or brachytherapy were included from the FOcal RECurrent Assessment and Salvage Treatment (FORECAST) trial (NCT01883128; 2014-2018; six centres), and from the high-intensity focussed ultrasound (HIFU) Evaluation and Assessment of Treatment (HEAT) and International Cryotherapy Evaluation (ICE) UK-based registries (2006-2022; nine centres)...
June 29, 2023: BJU International
#36
Focal therapy of prostate cancer: Assessment with prostate-specific membrane antigen (PSMA) imaging.
Mark Topoozian, Jeremie Calais, Ely Felker, Anthony Sisk, Samantha Gonzalez, Sean J Lee, Leonard S Marks
Focal therapy of prostate cancer (PCa) is currently of great interest, but a metric of success. other than biopsy, is not yet available. In a patient with a repeatedly negative MRI and negative systematic biopsies, a scan employing the radioisotope 68 Ga-PSMA-11 PET/CT identified a PSMA-avid hotspot in the prostate. PSMA-guided biopsy confirmed the diagnosis of a clinically-significant PCa. Following ablation of the lesion with high-intensity focused ultrasound (HIFU), the PSMA-avid lesion disappeared and targeted biopsy confirmed a fibrotic scar with no residual cancer...
September 2023: Urology Case Reports
#37
JOURNAL ARTICLE
Yang Pan, Shangren Wang, Hang Zhou, Shuai Niu, Xiaoqiang Liu
PURPOSE: High-intensity focused ultrasound ablation (HIFU) is emerging as more data on its efficacy arises for prostate cancer (PCa). However, it is indefinite whether to combine endoscopic resection and uncertain to say who the ideal candidates are for the combined treatment. Therefore, we aimed to conduct a meta-analysis to compare outcomes of sole HIFU therapy with that of HIFU in combination with endoscopic resection in patients with localized PCa. MATERIALS AND METHODS: Electronic databases were searched following the PRISMA guidelines and PICOS formats...
June 18, 2023: Urology Journal
#38
REVIEW
Hector Ayerra Perez, Javier Fermín Barba Abad, Javier Extramiana Cameno
Radical treatments and active surveillance are valid therapeutic approaches for low-risk prostate cancer. The oncologic effectiveness and morbidity of Radical Prostatectomy (RP) and radiotherapy have been broadly validated. Focal therapies pursue to reduce the morbidity observed after radical treatments, while preserving the oncologic effectiveness. This study aims to review the state-of-the-art about principles, oncologic effectiveness, morbidity, and side-effects associated with leading focal therapies. We review and summarize articles related with Cryotherapy, High-Intensity Focal Ultrasound (HIFU), Photodynamic Therapy (PDT), and Irreversible Electroporating (IRE) published in MEDLINE from 2000 to 2022...
December 2023: Clinical Genitourinary Cancer
#39
JOURNAL ARTICLE
P B Rosnitskiy, S A Tsysar, M M Karzova, S V Buravkov, P G Malkov, N V Danilova, E M Ponomarchuk, O A Sapozhnikov, T D Khokhlova, G R Schade, A D Maxwell, Y-N Wang, A V Kadrev, A L Chernyaev, D A Okhobotov, A A Kamalov, V A Khokhlova
Focused ultrasound technologies are of growing interest for noninvasive ablation of localized prostate cancer (PCa). Here we present the results of the first case study evaluating the feasibility of non-thermal mechanical ablation of human prostate adenocarcinoma tissue using the boiling histotripsy (BH) method on ex vivo tissue. High intensity focused ultrasound field was generated using a 1.5-MHz custom-made transducer with nominal F#=0.75. A sonication protocol of 734 W acoustic power, 10-ms long BH-pulses, 30 pulses per focal spot, 1 % duty cycle, and 1 mm distance between single foci was tested in an ex vivo human prostate tissue sample containing PCa...
May 7, 2023: Ultrasonics
#40
REVIEW
Randal H Henderson, Curtis Bryant, R Charles Nichols, William M Mendenhall, Nancy P Mendenhall
BACKGROUND: Locally recurrent prostate cancer following primary external beam radiotherapy without distant metastasis is a challenging problem, with no current consensus on the optimal management of these patients. Traditional whole-gland salvage treatments offered up to a 50% 5-year disease-free survival rate but with troubling levels of risk for significant complications. Recent progress in advanced imaging techniques has allowed a more accurate selection of patients with local-only recurrence and a selection of patients that may be suitable for newer partial-gland salvage treatments that may reduce late complications...
May 7, 2023: Prostate
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