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EDITORIAL
Viviany R Taqueti, Valentin Fuster
No abstract text is available yet for this article.
May 7, 2024: Journal of the American College of Cardiology
#2
REVIEW
Rodrigo Estévez-Loureiro, Roberto Lorusso, Maurizio Taramasso, Gianluca Torregrossa, Annapoorna Kini, Pedro R Moreno
Severe acute mitral regurgitation after myocardial infarction includes partial and complete papillary muscle rupture or functional mitral regurgitation. Although its incidence is <1%, mitral regurgitation after acute myocardial infarction frequently causes hemodynamic instability, pulmonary edema, and cardiogenic shock. Medical management has the worst prognosis, and mortality has not changed in decades. Surgery represents the gold standard, but it is associated with high rates of morbidity and mortality...
May 7, 2024: Journal of the American College of Cardiology
#3
REVIEW
James A Goldstein, Stamatios Lerakis, Pedro R Moreno
Right ventricular infarction (RVI) complicates 50% of cases of acute inferior ST-segment elevation myocardial infarction, and is associated with high in-hospital morbidity and mortality. Ischemic right ventricular (RV) systolic dysfunction decreases left ventricular preload delivery, resulting in low-output hypotension with clear lungs, and disproportionate right heart failure. RV systolic performance is generated by left ventricular contractile contributions mediated by the septum. Augmented right atrial contraction optimizes RV performance, whereas very proximal occlusions induce right atrial ischemia exacerbating hemodynamic compromise...
May 7, 2024: Journal of the American College of Cardiology
#4
MULTICENTER STUDY
Meng-Meng Yu, Ming-Liang Wang, Jin-Jin Wang, Bo-Li Lin, Xin Zhao, Xin-Wei Tao, Yin-Yin Chen, Peng-Yang Li, Jing-Kun Zhang, Jun-Bo Ge, Hang Jin, Meng-Su Zeng
BACKGROUND: Lipoprotein(a) (Lp[a]) is associated with an increased risk of myocardial infarction (MI). However, the mechanism underlying this association has yet to be fully elucidated. OBJECTIVES: This multicenter study aimed to investigate whether association between Lp(a) and MI risk is reinforced by the presence of low-attenuation plaque (LAP) identified by coronary computed tomography angiography (CCTA). METHODS: In a derivation cohort, a total of 5,607 patients with stable chest pain suspected of coronary artery disease who underwent CCTA and Lp(a) measurement were prospectively enrolled...
May 7, 2024: Journal of the American College of Cardiology
#5
JOURNAL ARTICLE
Roland Jäger, Matthias Hoke, Florian J Mayer, Stefanie Boden, Cornelia Englisch, Cihan Ay, Robert Kralovics, Christoph J Binder
BACKGROUND: The expansion of hematopoietic stem cells caused by acquired somatic mutations (clonal hematopoiesis [CH]) is a novel cardiovascular risk factor. The prognostic value of CH in patients with carotid atherosclerosis remains to be evaluated. OBJECTIVES: This study assessed the prognostic significance of CH in patients with atherosclerosis as detected by ultrasound of the carotid artery. METHODS: We applied deep sequencing of selected genomic regions within the genes DNMT3A, TET2, ASXL1, and JAK2 to screen for CH in 968 prospectively collected patients with asymptomatic carotid atherosclerosis evaluated by duplex sonography...
May 7, 2024: Journal of the American College of Cardiology
#6
(no author information available yet)
No abstract text is available yet for this article.
April 30, 2024: Journal of the American College of Cardiology
#7
REVIEW
Odayme Quesada, Daniela Crousillat, Fatima Rodriguez, Katia Bravo-Jaimes, Joan Briller, Modele O Ogunniyi, Deirdre J Mattina, Niti R Aggarwal, Carlos J Rodriguez, Glaucia Maria Moraes De Oliveira, Gladys Velarde
Cardiovascular disease affects 37% of Hispanic women and is the leading cause of death among Hispanic women in the United States. Hispanic women have a higher burden of cardiovascular risk factors, are disproportionally affected by social determinants of health, and face additional barriers related to immigration, such as discrimination, language proficiency, and acculturation. Despite this, Hispanic women show lower rates of cardiovascular disease and mortality compared with non-Hispanic White women. However, this "Hispanic paradox" is challenged by recent studies that account for the diversity in culture, race, genetic background, country of origin, and social determinants of health within Hispanic subpopulations...
April 30, 2024: Journal of the American College of Cardiology
#8
REVIEW
Romain Boulestreau, Mateusz Śpiewak, Andrzej Januszewicz, Reinhold Kreutz, Tomasz J Guzik, Magdalena Januszewicz, Maria Lorenza Muiesan, Alexandre Persu, Pantelis Sarafidis, Massimo Volpe, Anna Zaleska-Żmijewska, Bert-Jan H van den Born, Franz H Messerli
Malignant hypertension (MHT) is a hypertensive emergency with excessive blood pressure (BP) elevation and accelerated disease progression. MHT is characterized by acute microvascular damage and autoregulation failure affecting the retina, brain, heart, kidney, and vascular tree. BP must be lowered within hours to mitigate patient risk. Both absolute BP levels and the pace of BP rise determine risk of target-organ damage. Nonadherence to the antihypertensive regimen remains the most common cause for MHT, although antiangiogenic and immunosuppressant therapy can also trigger hypertensive emergencies...
April 30, 2024: Journal of the American College of Cardiology
#9
EDITORIAL
Tianyi Huang
No abstract text is available yet for this article.
April 30, 2024: Journal of the American College of Cardiology
#10
JOURNAL ARTICLE
Alexander Iribarne, Sundos H Alabbadi, Alan J Moskowitz, Gorav Ailawadi, Vinay Badhwar, Marc Gillinov, Vinod H Thourani, Keith B Allen, Michael E Halkos, Nirav C Patel, Robert S Kramer, David D'Alessandro, Samantha Raymond, Helena L Chang, Lopa Gupta, Kathleen N Fenton, Wendy C Taddei-Peters, Michael W A Chu, Volkmar Falk, Joanna Chikwe, Neal Jeffries, Emilia Bagiella, Patrick T O'Gara, Annetine C Gelijns, Natalia N Egorova
BACKGROUND: Tricuspid valve annuloplasty (TA) during mitral valve repair (MVr) is associated with increased risk of permanent pacemaker (PPM) implantation, but the magnitude of risk and long-term clinical consequences have not been firmly established. OBJECTIVES: This study assesses the incidence rates of PPM implantation after isolated MVr and following MVr with TA as well as the associated long-term clinical consequences of PPM implantation. METHODS: State-mandated hospital discharge databases of New York and California were queried for patients undergoing MVr (isolated or with concomitant TA) between 2004 and 2019...
April 30, 2024: Journal of the American College of Cardiology
#11
MULTICENTER STUDY
Eva Cabrera-Romero, Juan Pablo Ochoa, Roberto Barriales-Villa, Francisco José Bermúdez-Jiménez, Vicente Climent-Payá, Esther Zorio, María Angeles Espinosa, María Gallego-Delgado, Marina Navarro-Peñalver, Xabier Arana-Achaga, Jesús Piqueras-Flores, Victoria Espejo-Bares, José F Rodríguez-Palomares, Gemma Lacuey-Lecumberri, Javier López, Coloma Tiron, María Luisa Peña-Peña, Jose M García-Pinilla, Rebeca Lorca, Tomas Ripoll-Vera, Carles Díez-López, María Victoria Mogollon, Ana García-Álvarez, Luis Martínez-Dolz, María Brion, Jose María Larrañaga-Moreira, Juan Jiménez-Jáimez, María Isabel García-Álvarez, Silvia Vilches, Eduardo Villacorta, María Sabater-Molina, Itziar Solla-Ruiz, Ana Royuela, Fernando Domínguez, Jesús G Mirelis, Pablo Garcia-Pavia
BACKGROUND: Disease penetrance in genotype-positive (G+) relatives of families with dilated cardiomyopathy (DCM) and the characteristics associated with DCM onset in these individuals are unknown. OBJECTIVES: This study sought to determine the penetrance of new DCM diagnosis in G+ relatives and to identify factors associated with DCM development. METHODS: The authors evaluated 779 G+ patients (age 35.8 ± 17.3 years; 459 [59%] females; 367 [47%] with variants in TTN) without DCM followed at 25 Spanish centers...
April 30, 2024: Journal of the American College of Cardiology
#12
EDITORIAL
Subhash Banerjee, Zachary P Rosol
No abstract text is available yet for this article.
April 30, 2024: Journal of the American College of Cardiology
#13
RANDOMIZED CONTROLLED TRIAL
Marc P Bonaca, Deepak L Bhatt, Tabassome Simon, Kim Michael Fox, Shamir Mehta, Robert A Harrington, Lawrence A Leiter, Warren H Capell, Claes Held, Anders Himmelmann, Wilhelm Ridderstråle, Jersey Chen, Jane J Lee, Yang Song, Marielle Andersson, Jayne Prats, Mikhail Kosiborod, Darren K McGuire, Ph Gabriel Steg
BACKGROUND: Ticagrelor reduced major adverse cardiovascular events (MACE) and increased bleeding in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease. Limb events including revascularization, acute limb ischemia (ALI), and amputation are major morbidities in patients with T2DM and atherosclerosis. OBJECTIVES: This study sought to determine the effect of ticagrelor on limb events. METHODS: Patients were randomized to ticagrelor or placebo on top of aspirin and followed for a median of 3 years...
April 30, 2024: Journal of the American College of Cardiology
#14
JOURNAL ARTICLE
Xinyu Zhu, Yuan Tian, Ying Shi, Jianxiu Lian, Honghu Shen, Lulu Li, Haishan Wu, Pengfei Liu
Sudden cardiac death (SCD) represents the most severe complication of hypertrophic cardiomyopathy (HCM). However, the relationship between strain, strain rate, and risk factors in SCD risk stratification remains elusive. The study aimed to assess the attenuation of strain and strain rate in HCM by feature-tracking cardiac magnetic resonance (FT-CMR). All strain and strain rates were obtained automatically by FT, with manual adjustment of endocardial and epicardial borders. Strain indicators included left ventricular (LV) global longitudinal (GLS), circumferential (GCS), radial strain (GRS), peak diastolic-longitudinal (PD-LSR), circumferential (PD-CSR), and radial strain rate (PD-RSR)...
April 18, 2024: American Journal of Cardiology
#15
JOURNAL ARTICLE
Lukas Lanser, Gerhard Poelzl, Moritz Messner, Maria Ungericht, Marc-Michael Zaruba, Jakob Hirsch, Stefan Hechenberger, Stefan Obersteiner, Bernhard Koller, Hanno Ulmer, Guenter Weiss
BACKGROUND: Iron deficiency (ID) is a frequent comorbidity in patients with acute (AHF) and chronic heart failure (CHF) associated with morbidity and death. We aimed to better characterize iron homeostasis in patients with heart failure applying different biomarkers and to evaluate the accuracy of current ID definition by the European Society of Cardiology/American College of Cardiology/American Heart Association to indicate tissue iron availability and demand. METHODS AND RESULTS: We performed a retrospective cohort study investigating 277 patients with AHF and 476 patients with CHF between February 2021 and May 2022...
April 19, 2024: Journal of the American Heart Association
#16
JOURNAL ARTICLE
Wayne B Batchelor, Carlos E Sanchez, Paul Sorajja, James E Harvey, Benjamin Z Galper, Anapoorna Kini, Patricia Keegan, Kendra J Grubb, Ruth Eisenberg, Toby Rogers
BACKGROUND: Next-day discharge (NDD) outcomes following uncomplicated self-expanding transcatheter aortic valve replacement have not been studied. Here, we compare readmission rates and clinical outcomes in NDD versus non-NDD transcatheter aortic valve replacement with Evolut. METHODS AND RESULTS: Society of Thoracic Surgeons/American College of Cardiology TVT (Transcatheter Valve Therapy) Registry patients (n=29 597) undergoing elective transcatheter aortic valve replacement with self-expanding supra-annular valves (Evolut R, PRO, and PRO+) from July 2019 to June 2021 were stratified by postprocedure length of stay: ≤1 day (NDD) versus >1 day (non-NDD)...
April 19, 2024: Journal of the American Heart Association
#17
JOURNAL ARTICLE
Jolien W Roos-Hesselink, Chiara Pelosi, Margarita Brida, Julie De Backer, Sabine Ernst, Werner Budts, Helmut Baumgartner, Erwin Oechslin, Daniel Tobler, Adrienne H Kovacs, Giovanni Di Salvo, Jolanda Kluin, Michael A Gatzoulis, Gerhard P Diller
BACKGROUND AND AIM: Congenital heart disease (CHD) is the most common birth defect with prevalence of 0.8%. Thanks to tremendous progress in medical and surgical practice, nowadays, >90% of children survive into adulthood. Recently European Society of Cardiology (ESC), American College of Cardiology (ACC)/ American Heart Association (AHA) issued guidelines which offer diagnostic and therapeutic recommendations for the different defect categories. However, the type of technical exams and their frequency of follow-up may vary largely between clinicians and centres...
April 16, 2024: International Journal of Cardiology
#18
JOURNAL ARTICLE
Karen P Alexander
No abstract text is available yet for this article.
April 23, 2024: Journal of the American College of Cardiology
#19
EDITORIAL
Ashok Krishnaswami
No abstract text is available yet for this article.
April 23, 2024: Journal of the American College of Cardiology
#20
REVIEW
Veraprapas Kittipibul, Zachary L Cox, Supavit Chesdachai, Mona Fiuzat, JoAnn Lindenfeld, Robert J Mentz
Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have been shown to reduce adverse cardiovascular events in patients with type 2 diabetes mellitus, all-cause mortality, and heart failure hospitalization in patients with heart failure, as well as adverse renal outcomes. However, concerns regarding the heightened risk of genitourinary (GU) infections, particularly urinary tract infections, remain a significant barrier to their wider adoption. Addressing these misconceptions using existing evidence is needed to ensure proper risk-benefit assessment and optimal utilization of this efficacious therapy...
April 23, 2024: Journal of the American College of Cardiology
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