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JOURNAL ARTICLE
Hyun Sook Hwang, Mi Hyun Lee, Hyun Ah Kim
Eukaryotic initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) binds eIF4E and represses protein translation by displacing it from the mRNA. In this study, we investigated the influence of 4E-BP1 translational apparatus on the regulation of transforming growth factor-beta 1 (TGF-β1)-induced anabolic signaling in chondrocytes. The level of 4E-BP1 expression was significantly higher in human OA cartilage than normal cartilage. TGF-β1 increased total protein synthesis, including aggrecan (ACAN) and collagen type II (Col II), together with activation of Akt/mTOR signaling pathway...
June 2, 2020: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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JOURNAL ARTICLE
Lan Zhang, Tian-Liu Peng, Le Wang, Xiang-He Meng, Wei Zhu, Yong Zeng, Jia-Qiang Zhu, Yu Zhou, Hong-Mei Xiao, Hong-Wen Deng
PURPOSE: As a crucial physiological transition during the women's life, menopause occurs with growing risks of health issues like osteoporosis. To identify postmenopausal osteoporosis-related genes, we performed transcriptome-wide expression analyses for human Peripheral Blood Monocytes (PBM) using Affymetrix 1.0 ST arrays in 40 Caucasian postmenopausal women with discordant Bone Mineral Density (BMD) levels. METHODS: We performed Multiscale Embedded Gene Co-Expression Network Analysis (MEGENA) to study functionally orchestrating clusters of differentially expressed genes in form of functional networks...
June 1, 2020: Journal of Clinical Endocrinology and Metabolism
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JOURNAL ARTICLE
Dejene M Tufa, Tyler Shank, Ashley M Yingst, George Devon Trahan, Seonhui Shim, Jessica Lake, Renee Woods, Kenneth Jones, Michael R Verneris
Numerous cell types modulate hematopoiesis through soluble and membrane bound molecules. Whether developing hematopoietic progenitors of a particular lineage modulate the differentiation of other hematopoietic lineages is largely unknown. Here we aimed to investigate the influence of myeloid progenitors on CD34+ cell differentiation into CD56+ innate lymphocytes. Sorted CD34+ cells cultured in the presence of stem cell factor (SCF) and FMS-like tyrosine kinase 3 ligand (FLT3L) give rise to numerous cell types, including progenitors that expressed the prolactin receptor (PRLR)...
April 14, 2020: Scientific Reports
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JOURNAL ARTICLE
Yu Zhu, Chao Yu, Shougang Zhuang
Protein arginine methyltransferase 1 (PRMT1), which primarily causes asymmetric arginine methylation of histone and nonhistone proteins, has been found to activate gene expression and mediate multiple pathological processes. Its role in renal fibrosis, however, remains unclear. In this study, we observed that PRMT1 and its specific epigenetic marker, asymmetric di-methylated histone 4 arginine 3 (H4R3Me2a), were highly expressed in cultured renal interstitial fibroblasts. Treatment of PRMT1 with AMI-1, a selective inhibitor of PRMT1, or silencing PRMT1 with a small interfering RNA inhibited serum- and transforming growth factor beta1 (TGFβ1)-induced expression of α-smooth muscle actin (α-SMA) and collagen 1, two hallmarks of renal fibroblast activation, in a dose- and time-dependent manner...
December 9, 2019: American Journal of Physiology. Renal Physiology
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JOURNAL ARTICLE
S-H Fang, L Chen, H-H Chen, Y-F Li, H-B Luo, D-Q Hu, P Chen
OBJECTIVE: The aim of this study was to explore the role of micro ribonucleic acid (miR)-15b in steroid-induced osteonecrosis of the femoral head (SONFH) and its potential mechanism. PATIENTS AND METHODS: Bone marrow tissues were collected from 5 patients with glucocorticoid (GC)-induced ONFH (GC-ONFH, GC group) and 5 patients with secondary ONFH (control group) undergoing total hip replacement in our hospital from July 2016 to August 2017. Subsequently, bone marrow mesenchymal stem cells (BMSCs) were separated from bone marrow extracted and cultured in vitro...
November 2019: European Review for Medical and Pharmacological Sciences
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JOURNAL ARTICLE
Lifang Ma, Hongyuan Jiang, Xin Xu, Congcong Zhang, Yongjie Niu, Zhixian Wang, Yuquan Tao, Yan Li, Feng Cai, Xiao Zhang, Xinghe Wang, Yongchun Yu
Tanshinone IIA (TanIIA)-an active constituent of Salvia miltiorrhiza , a traditional Chinese medicinal plant-is known to have blood circulation promotion and anti-tumor properties. Tan IIA can induce tumor cell death and inhibit tumor growth. However, the functions and underling molecular mechanisms of Tan IIA action on human liver cancer cells remain poorly understand. In this study, we found that Tanshinone IIA mediates SMAD7-YAP interaction to induce liver cancer cell apoptosis and inhibit cell growth and migration by inactivating the transforming growth factor beta (TGF-β) signaling pathway...
November 11, 2019: Aging
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JOURNAL ARTICLE
Jung Hwan Hwang, Tae-Hwan Kim, Yong-Hoon Kim, Jung-Ran Noh, Dong-Hee Choi, Kyoung-Shim Kim, Eun-Young Lee, Byoung-Chan Kim, Myung Hee Kim, Ho Kim, Tae Geol Lee, Jong-Soo Lee, Chul-Ho Lee
Dysregulated immune responses and impaired function in intestinal epithelial cells contribute to the pathogenesis of inflammatory bowel disease (IBD). Growth arrest and DNA damage-inducible 45 beta (Gadd45β) has been implicated in the pathogenesis of various inflammatory symptoms. However, the role of Gadd45β in IBD is completely unknown. This study aimed to evaluate the role of Gadd45β in IBD. Gadd45β-KO mice exhibited drastically greater susceptibility to dextran sulfate sodium (DSS)-induced colitis and mortality than C57BL/6J mice...
October 30, 2019: Experimental & Molecular Medicine
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JOURNAL ARTICLE
Edith Sierra-Mondragon, Rafael Rodríguez-Muñoz, Carmen Namorado-Tonix, Eduardo Molina-Jijon, Daniel Romero-Trejo, Jose Pedraza-Chaverri, Jose L Reyes
Diabetic nephropathy (DN) involves damage associated to hyperglycemia and oxidative stress. Renal fibrosis is a major pathologic feature of DN. The aim of this study was to evaluate anti-fibrogenic and renoprotective effects of all-trans retinoic acid (ATRA) in isolated glomeruli and proximal tubules of diabetic rats. Diabetes was induced by single injection of streptozotocin (STZ, 60 mg/Kg). ATRA (1 mg/Kg) was administered daily by gavage, from days 3-21 after STZ injection. ATRA attenuated kidney injury through the reduction of proteinuria, renal hypertrophy, increase in natriuresis, as well as early markers of damage such as β2-microglobulin, kidney injury molecule-1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL)...
September 25, 2019: Biomolecules
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JOURNAL ARTICLE
Liting Zhang, Dan Zhou, Junfeng Li, Xiaoming Yan, Jun Zhu, Ping Xiao, Tuo Chen, Xiaodong Xie
BACKGROUND The role of bone marrow-derived mesenchymal stem cells (BM-MSCs) in liver fibrosis remains poorly understood. This study aimed to use a mouse model of carbon tetrachloride (CCL₄)-induced liver fibrosis to investigate the effects of BM-MSCs during liver hypoxia and the involvement of the transforming growth factor beta 1 (TGF-ß1) and SMADs pathway. MATERIAL AND METHODS Thirty C57BL/6 mice were randomly divided into the control group (n=10), the model group (n=10), and the BM-MSC-treated model group (n=10)...
September 24, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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JOURNAL ARTICLE
Yueqiu Wang, Hui Li, Yang Li, Yihan Zhao, Fangfei Xiong, Yining Liu, Hongru Xue, Zhenyu Yang, Sha Ni, Abbas Sahil, Hui Che, Lihong Wang
Coriolus versicolor (CV) is a traditional medicine and food mushroom. Our previous study demonstrated that CV extract exhibited anti-hyperglycemia and anti-insulin resistance effects. However, the effect of CV on cardiac function in diabetic cardiomyopathy (DCM) remains unclear. Therefore, we aimed to investigate the effect of CV on cardiac function in diabetes mellitus (DM) rats. We found that the cardiac dysfunction of DM rats was markedly improved by CV extract treatment. CV extract administration significantly attenuated cardiac fibrosis in DM rats, which was accompanied by suppressed transforming growth factor beta 1 (TGF-β1)/Smad signaling as indicated by decreased levels of TGF-β1, p-Smad2, and p-Smad3 and increased Smad7 expression...
July 23, 2019: Phytotherapy Research: PTR
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JOURNAL ARTICLE
Jinling Sun, Jinxu Zheng, Xiaodong Shi, Hai Qian, Chengji Jin, Lili Xu
Objective To investigate the effect of saikosaponin D (SSD) on the proliferation and transformation of human embryonic lung fibroblasts (HELFs) induced by transforming growth factor-beta 1 (TGF-β1) and the regulation of signal pathway of TGF-β1/Smads family. Methods HELFs were cultured in vitro and divided into 5 groups: a control group, 1 ng/mL TGF-β1-induced group, 1 ng/mL TGF-β1 combined with 0.5 μmol/L SSD treatment group, 1 ng/mL TGF-β1 combined with 1 μmol/L SSD treatment group, and 1 ng/mL TGF-β1 combined with 2 μmol/L SSD treatment group...
March 2019: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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JOURNAL ARTICLE
Veronika Fedirko, Mazda Jenab, Catherine Méplan, Jeb S Jones, Wanzhe Zhu, Lutz Schomburg, Afshan Siddiq, Sandra Hybsier, Kim Overvad, Anne Tjønneland, Hanane Omichessan, Vittorio Perduca, Marie-Christine Boutron-Ruault, Tilman Kühn, Verena Katzke, Krasimira Aleksandrova, Antonia Trichopoulou, Anna Karakatsani, Anastasia Kotanidou, Rosario Tumino, Salvatore Panico, Giovanna Masala, Claudia Agnoli, Alessio Naccarati, Bas Bueno-de-Mesquita, Roel C H Vermeulen, Elisabete Weiderpass, Guri Skeie, Therese Haugdahl Nøst, Leila Lujan-Barroso, J Ramón Quirós, José María Huerta, Miguel Rodríguez-Barranco, Aurelio Barricarte, Björn Gylling, Sophia Harlid, Kathryn E Bradbury, Nick Wareham, Kay-Tee Khaw, Marc Gunter, Neil Murphy, Heinz Freisling, Kostas Tsilidis, Dagfinn Aune, Elio Riboli, John E Hesketh, David J Hughes
Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengate assays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk...
April 25, 2019: Nutrients
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JOURNAL ARTICLE
Ya-Lan Pan, Yong Ma, Yang Guo, Juan Tu, Ge-Pu Guo, Shendu Marshall Ma, Su-Yang Zheng, Peng-Cheng Tu, Bei-Bei Yu, Gui-Cheng Huang
PURPOSE: Clematis chinensis Osbeck (CCO) is an essential herb that has been shown to promote the biological functions of cartilage cells. In this study, we aimed to explore whether and how low-intensity pulsed ultrasound (LIPUS) enhanced CCO delivery into chondrocytes and stimulated biological activity in vitro. METHODS: Chondrocytes were isolated from knee articular cartilage of 2-week-old rabbits and treated with LIPUS plus CCO or recombinant transforming growth factor beta 1 (TGF-β1; 0...
January 18, 2019: Journal of Medical Ultrasonics
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JOURNAL ARTICLE
Hongyan Gao, Zhe Bo, Qin Wang, Ling Luo, Haiyi Zhu, Yi Ren
OBJECTIVE: Salvanic Acid B (Sal B) was proved to show significant effect against fibrosis and myocardial injury. This study aimed to investigate the protective effects and the mechanisms of Sal B on myocardial fibrosis. METHODS: The mice were randomly assigned to five groups: control group, model group, positive group, low-dose group, high-dose group. Hematoxylin-Eosin (HE) staining and Masson staining were used to assess the myocardial physiological changes and measure the myocardial fibrosis area...
December 12, 2018: Biomedicine & Pharmacotherapy
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JOURNAL ARTICLE
Songyan Meng, Fan Yang, Yueqiu Wang, Ying Qin, Huimin Xian, Hui Che, Lihong Wang
Diabetic cardiomyopathy (DCM) is the leading cause of morbidity and mortality in diabetes mellitus (DM) patients. Previous studies have shown that the transforming growth factor-beta 1 (TGF-β1)/Smad signaling pathway plays a key role in the development of myocardial fibrosis in DCM. Silymarin (SMN) is used clinically to treat liver disorders and acts by influencing TGF-β1. However, the possible effects of silymarin on DCM remain to be elucidated. In our study, the DM animal model was induced by streptozotocin (STZ) injection...
November 29, 2018: Cell Biology International
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JOURNAL ARTICLE
Erik Hedrick, Kumaravel Mohankumar, Stephen Safe
TGFβ induces migration of lung cancer cells (A549, H460, and H1299), dependent on activation of c-Jun N-terminal kinase (JNK1), and is inhibited by the JNK1 inhibitor SP600125. Moreover, TGFβ-induced migration of the cells is also blocked by the nuclear export inhibitor leptomycin B (LMB) and the orphan nuclear receptor 4A1 (NR4A1) ligand 1,1-bis(3'-indolyl)-1-( p -hydroxyphenyl)methane (CDIM8), which retains NR4A1 in the nucleus. Subsequent analysis showed that the TGFβ/TGFβ receptor/PKA/MKK4 and -7/JNK pathway cascade phosphorylates and induces nuclear export of NR4A1, which in turn forms an active complex with Axin2, Arkadia (RNF111), and RNF12 (RLIM) to induce proteasome-dependent degradation of SMAD7 and enhance lung cancer cell migration...
August 2, 2018: Molecular Cancer Research: MCR
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JOURNAL ARTICLE
Gagandeep Kaur, Caiyun Grace Li, Andrew Chantry, Cherie Stayner, Julia Horsfield, Michael R Eccles
Canonical TGF-β1 signalling promotes tumor progression by facilitating invasion and metastasis, whereby release of TGF-β1, by (for example) infiltrating immune cells, induces epithelial to mesenchymal transition (EMT). PAX2, a member of the Paired box family of transcriptional regulators, is normally expressed during embryonic development, including in the kidney, where it promotes mesenchymal to epithelial transition (MET). PAX2 expression is silenced in many normal adult tissues. However, in contrast, PAX2 is expressed in several cancer types, including kidney, prostate, breast, and ovarian cancer...
June 1, 2018: Oncotarget
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JOURNAL ARTICLE
Shimaa Saad El-Din, Hanan Fouad, Laila Ahmed Rashed, Soheir Mahfouz, Rania Elsayed Hussein
Background: Transforming growth factor-beta (TGF-β) signaling is recognized as being critical for carcinogenesis. Vitamin D has proved to exert numerous tumor suppressive effects. Effects of bone marrow derived mesenchymal stem cells (BM-MSCs) on tumor progression are still controversial. The present study was conducted to evaluate the effects of BM-MSCs and vitamin D on TGF-β signaling in an experimental hepatocellular carcinoma (HCC) model in rats. Materials and Methods: The study was conducted on fifty female white albino rats divided equally into 5 groups: controls, HCC induced by diethyl-nitrosamine (DENA) and carbon tetrachloride (CCl4), HCC plus MSCs, HCC plus vitamin D and HCC plus both MSCs and vitamin D...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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JOURNAL ARTICLE
Yong-Guo Zhang, Megha Singhal, Zhijie Lin, Christopher Manzella, Anoop Kumar, Waddah A Alrefai, Pradeep K Dudeja, Seema Saksena, Jun Sun, Ravinder K Gill
Salmonella and Citrobacter are gram negative, members of Enterobacteriaceae family that are important causative agents of diarrhea and intestinal inflammation. TGF-β1 is a pleiotropic multifunctional cytokine that has been implicated in modulating the severity of microbial infections. How these pathogens alter the TGF-β1 signaling pathways in the intestine is largely unknown. Streptomycin-pretreated C57BL/6J mouse model colonized with S. typhimurium for 8 hours (acute) and 4 days (chronic) infection and FVB/N mice infected with C...
July 4, 2018: Gut Microbes
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JOURNAL ARTICLE
Menno Evert Groeneveld, Natalija Bogunovic, René John Philip Musters, Geert Jan Tangelder, Gerard Pals, Willem Wisselink, Dimitra Micha, Kak Khee Yeung
BACKGROUND: Marfan syndrome (MFS), a congenital connective tissue disorder leading to aortic aneurysm development, is caused by fibrillin-1 (FBN1) gene mutations. Transforming growth factor beta (TGF-β) might play a role in the pathogenesis. It is still a matter of discussion if and how TGF-β up-regulates the intracellular downstream pathway, although TGF-β receptor 3 (TGFBR3 or Betaglycan) is thought to be involved. We aimed to elucidate the role of TGFBR3 protein in TGF-β signaling in Marfan patients...
January 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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