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JOURNAL ARTICLE
Andrew M McDonald, Donna L Murdaugh, Katherine A Heinzman, Rex A Cardan, Jessica Jacob, John B Fiveash, L Burt Nabors, Courtney A Cooper, John M Hoyle, Desmin Milner, Carlos E Cardenas
OBJECTIVE: Radiation therapy (RT) is used selectively for patients with low-grade glioma (LGG) given the concerns for potential cognitive effects in survivors, but prior cognitive outcome studies among LGG survivors have had inconsistent findings. Translational studies that characterize changes in brain anatomy and physiology after treatment of LGG may help to both contextualize cognitive findings and improve the overall understanding of radiation effects in normal brain tissue. This study aimed to investigate the hypothesis that patients with LGG who are treated with RT will experience greater brain volume loss than those who do not receive RT...
April 26, 2024: Journal of Neurosurgery
#62
JOURNAL ARTICLE
Hosamadin Assadi, Nicholas Sawh, Ciara Bailey, Gareth Matthews, Rui Li, Ciaran Grafton-Clarke, Zia Mehmood, Bahman Kasmai, Peter P Swoboda, Andrew J Swift, Rob J van der Geest, Pankaj Garg
BACKGROUND: Left atrial (LA) assessment is an important marker of adverse cardiovascular outcomes. Cardiovascular magnetic resonance (CMR) accurately quantifies LA volume and function based on biplane long-axis imaging. We aimed to validate single-plane-derived LA indices against the biplane method to simplify the post-processing of cine CMR. METHODS: In this study, 100 patients from Leeds Teaching Hospitals were used as the derivation cohort. Bias correction for the single plane method was applied and subsequently validated in 79 subjects...
March 25, 2024: Tomography: a Journal for Imaging Research
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JOURNAL ARTICLE
Rei Nakamichi, Toshiaki Taoka, Rintaro Ito, Tadao Yoshida, Michihiko Sone, Shinji Naganawa
PURPOSE: The diploic veins have been suggested to be involved in the excretion of cerebrospinal fluid and intracranial waste products; however, to date, there have been no reports evaluating the space surrounding the diploic veins. Therefore, we aimed to visualize the distribution of gadolinium-based contrast agent (GBCA) in the space surrounding the diploic veins and to evaluate the spatial characteristics. MATERIALS AND METHODS: Ninety-eight participants (aged 14-84 years) were scanned 4 h after intravenous GBCA injection at Nagoya University Hospital between April 2021 and December 2022...
April 26, 2024: Japanese Journal of Radiology
#64
JOURNAL ARTICLE
Kamilla Avelino-de-Souza, Heitor Mynssen, Khallil Chaim, Ashley N Parks, Joana M P Ikeda, Haydée Andrade Cunha, Bruno Mota, Nina Patzke
The Guiana dolphin (Sotalia guianensis) is a common species along Central and South American coastal waters. Although much effort has been made to understand its behavioral ecology and evolution, very little is known about its brain. The use of ultra-high field MRI in anatomical descriptions of cetacean brains is a very promising approach that is still uncommon. In this study, we present for the first time a full anatomical description of the Guiana dolphin's brain based on high-resolution ultra-high-field magnetic resonance imaging, providing an exceptional level of brain anatomical details, and enriching our understanding of the species...
April 25, 2024: Brain Structure & Function
#65
JOURNAL ARTICLE
Yue Ma, Mengmeng Wang, Yuting Qiao, Yafei Wen, Yi Zhu, Ke Jiang, Jianxiu Lian, Dan Tong
RATIONALE AND OBJECTIVES: Investigate the feasibility of using deep learning-based accelerated 3D T1-weighted volumetric isotropic turbo spin-echo acquisition (VISTA) for vessel wall magnetic resonance imaging (VW-MRI), compared to traditional Compressed SENSE and optimize acceleration factor (AF) to obtain high-quality clinical images. METHODS: 40 patients with atherosclerotic plaques in the intracranial or carotid artery were prospectively enrolled in our study from October 1, 2022 to October 31, 2023 underwent high-resolution vessel wall imaging on a 3...
April 24, 2024: Academic Radiology
#66
JOURNAL ARTICLE
Hiroyuki Miura, Masahiro Koseki, Seiko Ide, Yasuhide Asaumi, Yoshiaki Morita, Yasutoshi Ohta, Katsunao Tanaka, Takeshi Okada, Takashi Omatsu, Soshiro Ogata, Tetsuya Fukuda, Yasushi Sakata, Teruo Noguchi
BACKGROUND: The structural and functional characteristics of the heart in patients with diabetes mellitus (DM) and without myocardial infarction (MI) are not fully understood. METHODS: We retrospectively analysed the data of patients with left ventricular ejection fraction (LVEF) ≥ 40% who underwent contrast-enhanced cardiac magnetic resonance imaging (CMR), which was also used to exclude MI, at two hospitals. Volumetric data and extracellular volume fraction (ECVf) of the myocardium evaluated using CMR were compared between patients with and without DM, and their association with diastolic function was evaluated...
April 23, 2024: International Journal of Cardiology
#67
JOURNAL ARTICLE
Yujiao Zhao, Cong You, Xin Zhou, Xiaotian Li, Cheng Zhang, Yanhong Wu, Wen Shen
OBJECTIVE: This study aimed to explore the value of ADC histogram based on whole lesion volume in distinguishing stage IA endometrial carcinoma from the endometrial polyp. METHODS: MR images of 108 patients with endometrial lesions confirmed by pathology were retrospectively analyzed, including 65 cases of stage IA endometrial carcinoma and 43 cases of endometrial polyp. The volumetric ADC histogram metrics and general imaging features were evaluated and measured simultaneously...
April 25, 2024: British Journal of Radiology
#68
JOURNAL ARTICLE
Xin Li, Mengqi Liu, Shuqiang Zhao, Zhiye Chen
BACKGROUND: A contrast agent-free approach would be preferable to the frequently used invasive approaches for evaluating cerebral perfusion in chronic migraineurs (CM). In this work, non-invasive quantitative volumetric perfusion imaging was used to evaluate alterations in cerebral perfusion in CM. METHODS: We used conventional brain structural imaging sequences and 3D pseudo-continuous arterial spin labeling (3D PCASL) to examine thirteen CM patients and fifteen normal controls (NCs)...
2024: Current medical imaging
#69
JOURNAL ARTICLE
Kavita Singh, Stephanie Barsoum, Kurt G Schilling, Yang An, Luigi Ferrucci, Dan Benjamini
Gray matter (GM) alterations play a role in aging-related disorders like Alzheimer's disease and related dementias, yet MRI studies mainly focus on macroscopic changes. Although reliable indicators of atrophy, morphological metrics like cortical thickness lack the sensitivity to detect early changes preceding visible atrophy. Our study aimed at exploring the potential of diffusion MRI in unveiling sensitive markers of cortical and subcortical age-related microstructural changes and assessing their associations with cognitive and behavioral deficits...
April 24, 2024: Aging Cell
#70
JOURNAL ARTICLE
Shaun Andrew Hanycz, Alborz Noorani, Peter Shih-Ping Hung, Matthew R Walker, Ashley B Zhang, Timur H Latypov, Mojgan Hodaie
INTRODUCTION: Patients with chronic pain frequently report cognitive symptoms that affect memory and attention, which are functions attributed to the hippocampus. Trigeminal neuralgia (TN) is a chronic neuropathic pain disorder characterized by paroxysmal attacks of unilateral orofacial pain. Given the stereotypical nature of TN pain and lack of negative symptoms including sensory loss, TN provides a unique model to investigate the hippocampal implications of chronic pain. Recent evidence demonstrated that TN is associated with macrostructural hippocampal abnormalities indicated by reduced subfield volumes; however, there is a paucity in our understanding of hippocampal microstructural abnormalities associated with TN...
June 2024: Pain Reports
#71
JOURNAL ARTICLE
Yong Hun Jang, Jusung Ham, Payam Hosseinzadeh Kasani, Hyuna Kim, Joo Young Lee, Gang Yi Lee, Tae Hwan Han, Bung-Nyun Kim, Hyun Ju Lee
The neurodevelopmental outcomes of preterm infants can be stratified based on the level of prematurity. We explored brain structural networks in extremely preterm (EP; < 28 weeks of gestation) and very-to-late (V-LP; ≥ 28 and < 37 weeks of gestation) preterm infants at term-equivalent age to predict 2-year neurodevelopmental outcomes. Using MRI and diffusion MRI on 62 EP and 131 V-LP infants, we built a multimodal feature set for volumetric and structural network analysis...
April 23, 2024: Scientific Reports
#72
JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#73
JOURNAL ARTICLE
Mika E Mononen, Mimmi K Liukkonen, Mikael J Turunen
Magnetic resonance imaging (MRI) offers superior soft tissue contrast compared to clinical X-ray imaging methods, while also providing accurate three-dimensional (3D) geometries, it could be reasoned to be the best imaging modality to create 3D finite element (FE) geometries of the knee joint. However, MRI may not necessarily be superior for making tissue-level FE simulations of internal stress distributions within knee joint, which can be utilized to calculate subject-specific risk for the onset and development of knee osteoarthritis (KOA)...
April 22, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
#74
JOURNAL ARTICLE
Subhashis Banerjee, Fredrik Nysjö, Dimitrios Toumpanakis, Ashis Kumar Dhara, Johan Wikström, Robin Strand
Radiological imaging to examine intracranial blood vessels is critical for preoperative planning and postoperative follow-up. Automated segmentation of cerebrovascular anatomy from Time-Of-Flight Magnetic Resonance Angiography (TOF-MRA) can provide radiologists with a more detailed and precise view of these vessels. This paper introduces a domain generalized artificial intelligence (AI) solution for volumetric monitoring of cerebrovascular structures from multi-center MRAs. Our approach utilizes a multi-task deep convolutional neural network (CNN) with a topology-aware loss function to learn voxel-wise segmentation of the cerebrovascular tree...
April 22, 2024: Scientific Reports
#75
JOURNAL ARTICLE
Gustavo Pacheco, Jorge Patricio Castillo-Lopez, Yolanda Villaseñor-Navarro, María-Ester Brandan
PURPOSE: Breast density is a significant risk factor for breast cancer and can impact the sensitivity of screening mammography. Area-based breast density measurements may not provide an accurate representation of the tissue distribution, therefore volumetric breast density (VBD) measurements are preferred. Dual-energy mammography enables volumetric measurements without additional assumptions about breast shape. In this work we evaluated the performance of a dual-energy decomposition technique for determining VBD by applying it to virtual anthropomorphic phantoms...
April 22, 2024: Journal of Applied Clinical Medical Physics
#76
JOURNAL ARTICLE
Shreya H Dhume, Kayode Balogun, Ambalika Sarkar, Sebastian Acosta, Howard T J Mount, Lindsay S Cahill, John G Sled, Lena Serghides
BACKGROUND: Combination antiretroviral therapy (ART) use in pregnancy has been pivotal in improving maternal health and reducing perinatal HIV transmission. However, children born HIV-exposed uninfected fall behind their unexposed peers in several areas including neurodevelopment. The contribution of in utero ART exposure to these deficits is not clear. Here we present our findings of neurocognitive outcomes in adult mice exposed in utero to ART. METHODS: Dams were treated with a combination of ritonavir-boosted atazanavir with either abacavir plus lamivudine (ABC/3TC + ATV/r) or tenofovir disoproxil fumarate plus emtricitabine (TDF/FTC + ATV/r), or water as a control, administered daily from day of plug detection to birth...
2024: Frontiers in Molecular Neuroscience
#77
Marta San Luciano, Carina R Oehrn, Sarah S Wang, John S Tolmie, Allisun Wiltshire, Rebecca E Graff, Jennifer Zhu, Philip A Starr
Background: Movement and tone disorders in children and young adults with cerebral palsy are a great source of disability. Deep brain stimulation (DBS) of basal ganglia targets has a major role in the treatment of isolated dystonias, but its efficacy in dyskinetic cerebral palsy (DCP) is lower, due to structural basal ganglia and thalamic damage and lack of improvement of comorbid choreoathetosis and spasticity. The cerebellum is an attractive target for DBS in DCP since it is frequently spared from hypoxic ischemic damage, it has a significant role in dystonia network models, and small studies have shown promise of dentate stimulation in improving CP-related movement and tone disorders...
April 1, 2024: Research Square
#78
JOURNAL ARTICLE
Yuan-Chen Chang, Kuang-Chen Yen, Po-Chin Liang, Ming-Chih Ho, Cheng-Maw Ho, Chih-Yang Hsiao, Chiu-Han Hsiao, Chia-Hsun Lu, Chih-Horng Wu
BACKGROUND: Preoperative imaging evaluation of liver volume and hepatic steatosis for the donor affects transplantation outcomes. However, computed tomography (CT) for liver volumetry and magnetic resonance spectroscopy (MRS) for hepatic steatosis are time consuming. Therefore, we investigated the correlation of automated 3D-multi-echo-Dixon sequence magnetic resonance imaging (ME-Dixon MRI) and its derived proton density fat fraction (MRI-PDFF) with CT liver volumetry and MRS hepatic steatosis measurements in living liver donors...
April 19, 2024: Journal of the Formosan Medical Association
#79
JOURNAL ARTICLE
Koren E Roach, Alyssa L Bird, Valentina Pedoia, Sharmila Majumdar, Richard B Souza
Limited information exists regarding abductor muscle quality variation across its length and which locations are most representative of overall muscle quality. This is exacerbated by time-intensive processes for manual muscle segmentation, which limits feasibility of large cohort analyses. The purpose of this study was to develop an automated and localized analysis pipeline that accurately estimates hip abductor muscle quality and size in individuals with mild-to-moderate hip osteoarthritis (OA) and identifies regions of each muscle which provide best estimates of overall muscle quality...
April 16, 2024: Magnetic Resonance Imaging
#80
JOURNAL ARTICLE
Kazumi Sogabe, Junichi Hata, Daisuke Yoshimaru, Kei Hagiya, Hirotaka James Okano, Hideyuki Okano
The field of aging biology, which aims to extend healthy lifespans and prevent age-related diseases, has turned its focus to the Callithrix jacchus (common marmoset) to understand the aging process better. This study utilized magnetic resonance imaging (MRI) to non-invasively analyze the brains of 216 marmosets, investigating age-related changes in brain structure; the relationship between body weight and brain volume; and potential differences between males and females. The key findings revealed that, similar to humans, Callithrix jacchus experiences a reduction in total intracranial volume, cortex, subcortex, thalamus, and cingulate volumes as they age, highlighting site-dependent changes in brain tissue...
April 16, 2024: Neuroscience Research
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