Brianna Steiert, Carolina M Icardi, Robert Faris, Paige N McCaslin, Parker Smith, Aloysius J Klingelhutz, Peter M Yau, Mary M Weber
The centrosome is the main microtubule organizing center of the cell and is crucial for mitotic spindle assembly, chromosome segregation, and cell division. Centrosome duplication is tightly controlled, yet several pathogens, most notably oncogenic viruses, perturb this process leading to increased centrosome numbers. Infection by the obligate intracellular bacterium Chlamydia trachomatis ( C.t. ) correlates with blocked cytokinesis, supernumerary centrosomes, and multipolar spindles; however, the mechanisms behind how C...
May 16, 2023: Proceedings of the National Academy of Sciences of the United States of America