Luca Villa, Alessia Libera Gazzonis, Chiara Perlotti, Sergio Aurelio Zanzani, Giuseppe Sironi, Maria Teresa Manfredi
A form of generalized demodectic mange in two dairy cows infected with Besnoitia besnoiti is described. The herd was endemically infected with bovine besnoitiosis; an overall seroprevalence of B. besnoiti antibodies of 23.5%, that increased up to 43.5% considering only cows, was reported. Two out of the cows seropositive to B. besnoiti, at clinical examination presented skin nodules, widespread all over the body, and in particular in anterior regions. Skin biopsies from the region of the neck were collected and the nodules were microscopically examined through compression method...
November 7, 2019: Parasitology International
Valentino Laquintana, Mulazim Hussain Asim, Angela Lopedota, Annalisa Cutrignelli, Antonio Lopalco, Massimo Franco, Andreas Bernkop-Schnürch, Nunzio Denora
Budesonide (BUD) is a low water soluble (S0 = 5.028·10-5 M) corticosteroid used as preferred therapy for the treatment of Eosinophilic Esophagitis (EoE), a chronic allergic-immune condition with an increased incidence in the paediatric population. Currently there are no commercial medicines indicated for EoE, and, therefore, in the hospital pharmacy the BUD is extemporaneously formulated as viscous oral suspension at the initial dose of 1-2 mg per day for children, highlighting the need of a mucoadhesive drug delivery system (MDDS) that adheres to the site of action and prolongs the therapeutic activity of the administered drug...
November 7, 2019: International Journal of Pharmaceutics
Pieter-Paul Hekking, W Gerald Teague
No abstract text is available yet for this article.
November 2019: Journal of Allergy and Clinical Immunology in Practice
Benito Benitez, Julia Mülli, Alexandar Tzankov, Christoph Kunz
BACKGROUND: Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare self-limiting condition of the oral mucosa. The lesion manifests as an isolated ulcer that can be either asymptomatic or associated with mild to severe pain, and in most cases, it affects the tongue. TUGSE lesions may mimic malignancy such as squamous cell carcinoma, CD30 positive lymphoproliferative disorder, or infectious diseases such as primary syphilis, tuberculosis, or Epstein-Barr virus mucocutaneous ulcer...
November 9, 2019: World Journal of Surgical Oncology
Thomas Greuter, Ikuo Hirano, Evan S Dellon
Despite advances in the pathological understanding of eosinophilic esophagitis (EoE), as of yet no single agent has been approved by the Food and Drug Agency to treat EoE. Off-label, EoE is currently treated by the three D's, which are drugs (particularly swallowed topical corticosteroids), dietary restriction and endoscopic dilation. In the recent past, considerable progress in terms of EoE treatment has been made: 1) new EoE-specific steroid formulations optimizing mucosal deposition have been developed, which has culminated in the recent approval of a budesonide effervescent tablet (BET) in Europe; 2) biologics used for other Th2-mediated diseases such as allergic asthma and atopic eczema, as well as purpose-developed biologics, have been studied in phase II trials in EoE; and 3) novel dietary restriction strategies have evolved...
November 6, 2019: Journal of Allergy and Clinical Immunology
Leticia García-Mochón, Manuel David Gil-Sierra, Emilio Jesús Alegre-Del Rey, Catalina Alarcón de la Lastra-Romero, Marina Sánchez-Hidalgo
OBJECTIVE: Mepolizumab is indicated as an additional treatment of severe refractory eosinophilic asthma. The observed differences in  population subgroups according to plasma eosinophil count, the  existence of patients with high levels of immunoglobulin E who are  candidates of omalizumab and mepolizumab, as well as mepolizumab's  economic impact, lead to make efficient economic studies for clinical  decision making. The aim was to analyze mepolizumab's cost-efficacy  and budget impact...
November 1, 2019: Farmacia Hospitalaria
Carolyn Newberry
PURPOSE OF REVIEW: Gluten is a commonly ingested polymeric protein found in wheat, barley, and rye that has gained recent notoriety because of its relationship to disease and health. Avoidance of gluten is appropriate in patients with a diagnosed gluten-related disorder and may have treatment implications in other diseases of the digestive tract. This review highlights current knowledge of gluten related disorders and the use of a gluten-free diet in gastrointestinal disease management...
November 9, 2019: Current Treatment Options in Gastroenterology
Sayuri Shirai, Shin'ichi Akiyama, Atsuko Kamijo-Ikemori, Tomo Suzuki, Daisuke Ichikawa, Junki Koike, Kenjiro Kimura, Yugo Shibagaki
A 30-year-old woman on steroid therapy for eosinophilia presented with nephrotic syndrome during steroid tapering. She was diagnosed with membranous nephropathy (MN) stage II-III (positive for IgG1 and IgG4) by renal biopsy. There was no evidence of secondary MN. Her urinary protein level was controlled to 0.5 g/day or less, and her eosinophil count in white blood cell differential was stabilized at less than 10% without increasing the steroid dosage. The renal specimen did not show any enhanced granular expression of PLA2R along the glomerular basement membrane, and PLA2R was not detected in the patient's serum...
November 8, 2019: CEN Case Reports
Paloma Campo, Gregorio Soto Campos, Marina Blanco Aparicio, Ana Moreira Jorge, Héctor Manuel González Expósito, Santiago Quirce, Ignacio Dávila
BACKGROUND: The appropriate identification of asthma phenotypes of responders to omalizumab would optimize the selection of treatment. OBJECTIVE: To describe the most frequent clinical phenotypes in patients with severe asthma responding to omalizumab and their clinical and pulmonary function improvement. METHODS: This was an observational, retrospective, multicenter study. Adult patients with severe asthma, who achieved good control after the first year of treatment with omalizumab were included...
October 21, 2019: Respiratory Medicine
Tadech Boonpiyathad, Zeynep Celebi Sözener, Pattraporn Satitsuksanoa, Cezmi A Akdis
Asthma is a chronic airway disease, which affects more than 300 million people. The pathogenesis of asthma exhibits marked heterogeneity with many phenotypes defining visible characteristics and endotypes defining molecular mechanisms. With the evolution of novel biological therapies, patients, who do not-respond to conventional asthma therapy require novel biologic medications, such as anti-IgE, anti-IL-5 and anti-IL4/IL13 to control asthma symptoms. It is increasingly important for physicians to understand immunopathology of asthma and to characterize asthma phenotypes...
November 5, 2019: Seminars in Immunology
Ting Wen, Marc E Rothenberg
Technical advances in single-cell RNA sequencing (scRNA-seq) render it possible to examine the transcriptomes of single cells in patients with allergic inflammation with high resolution in the context of their specific microenvironment, treatment, and disease status. Using a recently published scRNA-seq study of tissue T cells as an example, we introduce the major pipeline steps, illustrate the options of scRNA-seq platforms, summarize new knowledge gained from this study, and provide directions for future research...
November 2019: Journal of Allergy and Clinical Immunology
Femke M Prins, M Abdullah Said, Yordi J van de Vegte, Niek Verweij, Hilde E Groot, Pim van der Harst
Lower levels of physical activity (PA) have been associated with increased risk of cardiovascular disease. Worldwide, there is a shift towards a lifestyle with less PA, posing a serious threat to public health. One of the suggested mechanisms behind the association between PA and disease development is through systemic inflammation, in which circulating blood cells play a pivotal role. In this study we investigated the relationship between genetically determined PA and circulating blood cells. We used 68 single nucleotide polymorphisms associated with objectively measured PA levels to perform a Mendelian randomization analysis on circulating blood cells in 222,645 participants of the UK Biobank...
November 7, 2019: Genes
Nathalie J Plundrich, Andrew R Smith, Luke B Borst, Douglas B Snider, Tobias Käser, Evan S Dellon, Anthony T Blikslager, Jack Odle, Mary Ann Lila, Scott M Laster
BACKGROUND: Esophagitis with eosinophilia, inflammation, and fibrosis represents a chronic condition in humans with food allergies. OBJECTIVE: In this investigation we asked whether esophagitis with an eosinophilic component is observed in young pigs rendered allergic to hen egg white protein (HEWP). METHODS: Food allergy was induced in young pigs using two protocols. In one protocol, sensitized pigs were challenged by gavage with a single dose of HEWP...
November 8, 2019: Clinical and Experimental Allergy
Rongfei Wang, Xiting Nie, Shiyang Xu, Mingjie Zhang, Zhao Dong, Shengyuan Yu
BACKGROUND: Neuronal intranuclear inclusion disease (NIID) is considered a heterogeneous disease because of its highly variable clinical manifestations. To date, there are no reports of NIID patients presenting with hemiplegic migraine (HM)-like headache, or of HM and NIID co-occurring as comorbidity, and the connection between these 2 seemingly unrelated clinical conditions has yet to be established. METHOD: We present a patient with NIID who was previously diagnosed with HM...
November 8, 2019: Headache
Ayo O Omiyale, James Carton
Renal oncocytoma is a benign epithelial neoplasm typically composed of large cells with granular eosinophilic cytoplasm. Although rare, histologically worrisome features such as vascular and perinephric fat invasion have been reported. Of the 159 renal oncocytomas resected at our institution, 20 (12.6%) had vascular and/or perinephric fat invasion. Microscopically, 10 oncocytomas had perinephric fat invasion, 7 had vascular invasion and 3 had both vascular and perinephric fat invasion. Grossly, perinephric fat invasion was visible in three cases and tumour was identified within the branches of the renal vein in two cases...
January 2019: Therapeutic Advances in Urology
Farah Deshmukh, Anupama Vasudevan, Erika Mengalie
Background: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder often seen in outpatient clinics. Diagnosing IBS is often challenging, as it frequently presents with other complicated rheumatological and psychiatric conditions. Asthma has often been associated with gastrointestinal conditions such as gastroesophageal reflux disease and eosinophilic esophagitis. This review and meta-analysis aimed at a better understanding of the association between the conditions...
November 2019: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Miguel A Piris, L Jeffrey Medeiros, Kung-Chao Chang
Hodgkin lymphoma (HL) is composed of two distinct pathological entities, nodular lymphocyte predominant HL and classic HL, the latter with four subtypes. In contrast with most other human lymphomas, in which the neoplastic cells are a major population of the tumour constituents, the neoplastic 'Hodgkin (H) and Reed-Sternberg (RS)' cells usually account for less than 10% of tumour bulk against an inflammatory background. The neoplastic cells of HL are of B-cell lineage (PAX5+) in virtually all cases. HL usually affects young patients with a localised nodal disease and its clinical behaviour is typically indolent...
November 5, 2019: Pathology
Tian Meng Yan, Ya Gang Zuo
Bullous pemphigoid(BP)is an autoimmune blister disease caused by antibodies to the basement membrane zone.It usually exhibits tense bullae in skin and mucous membrane.BP patients can suffer from thrombosis due to hypercoagulation and/or hemorrhage due to the presence of anti-coagulation factors,which may be explained by the eosinophils,antibodies to the coagulation factors,and fibrinolytic system hyperactivity or inhibition.
October 30, 2019: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Takuya Hida, Toshinari Yamasaki, Haruka Banno, Yasushi Fuchigami, Kodai Hattahara, Maki Fujiwara, Ryosuke Suzuki, Yuki Kita, Takayuki Yoshino, Takayuki Goto, Atsuro Sawada, Shusuke Akamatsu, Ryoichi Saito, Takashi Kobayashi, Takahiro Inoue, Osamu Ogawa
Peritoneal dissemination or metastasis is a relatively rare presentation of renal cell carcinoma. We report four cases of advanced renal cell carcinoma with peritoneal metastases treated with nivolumab. Three cases showed an objective response in the metastatic lesions including peritoneal sites. After nivolumab administration, the computed tomography scan showed a transient enlargement of peritoneal lesions in two cases, which could be considered as pseudoprogression. Temporal changes of neutrophil-tolymphocyte ratio, C-reactive protein, and eosinophil ratio during the clinical course reflected the treatment effect of nivolumab in these patients, indicating that these could be potential biomarkers of the response...
October 2019: Hinyokika Kiyo. Acta Urologica Japonica
Ami B Patel, Anca Franzini, Emilie Leroy, Soo Jin Kim, Anthony D Pomicter, Lidvine Genet, Michael Xiao, Dongqing Yan, Jonathan Ahmann, Archana M Agarwal, Phillip Clair, Juanah Addada, Jonathan Lambert, Matthew Salmon, Gerald J Gleich, Nicholas Cp Cross, Stefan Constantinescu, Thomas O'Hare, Josef T Prchal, Michael W Deininger
The V617F mutation in the JH2 domain of JAK2 is an oncogenic driver in several myeloproliferative neoplasms (MPNs), including essential thrombocythemia, myelofibrosis, and polycythemia vera (PV). Other mutations in JAK2 have been identified in MPNs, most notably exon 12 mutations in PV. Here, we describe a novel recurrent mutation characterized by a common 4-amino acid deletion and variable 1-amino acid insertion (Leu583-Ala586DelInsSer/Gln/Pro) within the JH2 domain of JAK2. All four affected patients had eosinophilia, and both patients with Leu583-Ala586DelInsSer fulfilled diagnostic criteria of both PV and chronic eosinophilic leukemia (CEL)...
October 11, 2019: Blood
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