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JOURNAL ARTICLE
Pablo Solla-Suarez, Saleena Gul Arif, Fayeza Ahmad, Neelabh Rastogi, Andrew Meng, Joshua M Cohen, Julia Rodighiero, Nicolo Piazza, Giuseppe Martucci, Sandra Lauck, John G Webb, Dae H Kim, Bojan Kovacina, Jonathan Afilalo
IMPORTANCE: Osteosarcopenia is an emerging geriatric syndrome characterized by age-related deterioration in muscle and bone. Despite the established relevance of frailty and sarcopenia among older adults undergoing transcatheter aortic valve replacement (TAVR), osteosarcopenia has yet to be investigated in this setting. OBJECTIVE: To determine the association between osteosarcopenia and adverse outcomes following TAVR. DESIGN, SETTING, AND PARTICIPANTS: This is a post hoc analysis of the Frailty in Aortic Valve Replacement (FRAILTY-AVR) prospective multicenter cohort study and McGill extension that enrolled patients aged 70 years or older undergoing TAVR from 2012 through 2022...
May 15, 2024: JAMA Cardiology
#2
JOURNAL ARTICLE
Philippe Garot, Marie-Claude Morice, Dominick J Angiolillo, Josep Rodés- Cabau, Duk-Woo Park, Nicolas M Van Mieghem, Jean-Philippe Collet, Martin B Leon, Gunasekaran Sengottuvelu, Antoinette Neylon, Jurrien M Ten Berg, Darren Mylotte, Didier Tchétché, Mitchell W Krucoff, Michael J Reardon, Nicolo Piazza, Michael J Mack, Philippe Généreux, Raj Makkar, Kentaro Hayashida, Yohei Ohno, Shuichi Mochizuki, Yuko Shirai, Ryosuke Matsumara, Yu Jin, John G Webb, Donald E Cutlip, Mao Chen, Ernest Spitzer, Roxana Mehran, Davide Capodanno
<span style="font-size:12pt"><span style="font-family:Aptos,sans-serif">The identification and management of patients at high bleeding risk (HBR) undergoing transcatheter aortic valve implantation (TAVI) are of major importance, but the lack of standardised definitions is challenging for trial design, data interpretation, and clinical decision-making. The Valve Academic Research Consortium for High Bleeding Risk (VARC-HBR) is a collaboration among leading research organisations, regulatory authorities, and physician-scientists from Europe, the USA, and Asia, with a major focus on TAVI-related bleeding...
May 10, 2024: EuroIntervention
#3
JOURNAL ARTICLE
Nicolò Danesin, Laura Bonaldi, Annalisa Martines, Silvia Nalio, Roberta Bertorelle, Sofia Compagno, Raffaella Marcato, Sabrina Manni, Federico Scarmozzino, Marco Pizzi, Angelo Paolo Dei Tos, Alessandro Cellini, Greta Scapinello, Andrea Visentin, Livio Trentin, Francesco Piazza
The prognostic and predictive role of specific gene mutations in Waldenström Macroglobulinemia (WM) is well-ascertained whereas the clinical impact of chromosome aberrations is far less known. Recent work has provided initial evidence for an adverse prognostic impact of some aberrations, such as del(6q), while other studies suggest a possible relationship between some clinical features (e.g. advanced age and/or inflammatory status) and specific cytogenetic abnormalities. To add to the still limited knowledge on WM cytogenetics and its clinical implications, we herein report our experience in a cohort of WM patients across 23 years...
April 30, 2024: Annals of Hematology
#4
JOURNAL ARTICLE
Giovanna Mangiapane, Michela Notarangelo, Giulia Canarutto, Fabrizio Fabbiano, Emiliano Dalla, Monica Degrassi, Giulia Antoniali, Nicolò Gualandi, Veronica De Sanctis, Silvano Piazza, Vito Giuseppe D'Agostino, Gianluca Tell
The base excision repair (BER) Apurinic/apyrimidinic endonuclease 1 (APE1) enzyme is endowed with several non-repair activities including miRNAs processing. APE1 is overexpressed in many cancers but its causal role in the tumorigenic processes is largely unknown. We recently described that APE1 can be actively secreted by mammalian cells through exosomes. However, APE1 role in EVs or exosomes is still unknown, especially regarding a putative regulatory function on vesicular small non-coding RNAs. Through dedicated transcriptomic analysis on cellular and vesicular small RNAs of different APE1-depleted cancer cell lines, we found that miRNAs loading into EVs is a regulated process, dependent on APE1, distinctly conveying RNA subsets into vesicles...
April 25, 2024: Oncogene
#5
JOURNAL ARTICLE
Nicolò Danesin, Greta Scapinello, Dorella Del Prete, Elena Naso, Tamara Berno, Andrea Visentin, Laura Bonaldi, Annalisa Martines, Roberta Bertorelle, Fabrizio Vianello, Carmela Gurrieri, Renato Zambello, Chiara Castellani, Marny Fedrigo, Stefania Rizzo, Annalisa Angelini, Livio Trentin, Francesco Piazza
BACKGROUND: Renal injury related to Waldenström macroglobulinemia (WM) occurs in approximately 3% of patients. Kidney biopsy is crucial to discriminate between distinct histopathological entities such as glomerular (amyloidotic and non-amyloidotic), tubulo-interstitial and non-paraprotein mediated renal damage. In this context, disease characterization, management, relationship between renal, and hematological response have been poorly explored. We collected clinical, genetic and laboratory data of seven cases of biopsy-proven renal involvement by WM managed at our academic center and focused on three cases we judged paradigmatic discussing their histopathological patterns, clinical features, and therapeutic options...
April 2024: Cancer reports
#6
REVIEW
Davide Graci, Nicolò Piazza, Salvatore Ardagna, Alessandra Casuccio, Anton Drobov, Federica Geraci, Angelo Immordino, Alessandra Pirrello, Vincenzo Restivo, Riccardo Rumbo, Rosalba Stefano, Roberta Virone, Elena Zarcone, Palmira Immordino
Human papillomavirus (HPV) is the most prevalent sexually transmitted virus globally and a primary cause of cervical cancer, which ranks fourth among tumors in both incidence and mortality. Despite the availability of effective vaccines worldwide, HPV vaccination rates vary, especially among migrant and refugee populations. Indeed, migrant status may act as a determinant against accessing vaccinations, among many other factors. The objective of this paper is to evaluate barriers to and facilitators for accessing HPV vaccination in migrant and refugee populations...
February 29, 2024: Vaccines
#7
JOURNAL ARTICLE
Sara Terzoli, Paolo Marzano, Valentina Cazzetta, Rocco Piazza, Inga Sandrock, Sarina Ravens, Likai Tan, Immo Prinz, Simone Balin, Michela Calvi, Anna Carletti, Assunta Cancellara, Nicolò Coianiz, Sara Franzese, Alessandro Frigo, Antonio Voza, Francesca Calcaterra, Clara Di Vito, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
γδ T cells provide rapid cellular immunity against pathogens. Here, we conducted matched single-cell RNA-sequencing and γδ-TCR-sequencing to delineate the molecular changes in γδ T cells during a longitudinal study following mRNA SARS-CoV-2 vaccination. While the first dose of vaccine primes Vδ2 T cells, it is the second administration that significantly boosts their immune response. Specifically, the second vaccination uncovers memory features of Vδ2 T cells, shaped by the induction of AP-1 family transcription factors and characterized by a convergent central memory signature, clonal expansion, and an enhanced effector potential...
March 20, 2024: NPJ Vaccines
#8
JOURNAL ARTICLE
Elie Akl, Nazanin Sahami, Christopher Labos, Jacques Genest, Ali Zgheib, Nicolo Piazza, Sanjit Jolly
BACKGROUND: Colchicine has shown potential cardioprotective effects owing to its broad anti-inflammatory properties. We performed a meta-analysis to assess its safety and efficacy in secondary prevention in patients with established coronary artery disease (CAD). METHODS: We searched Ovid Healthstar, MEDLINE, and Embase (inception to May 2022) for randomized controlled trials (RCTs) evaluating the cardiovascular effects of colchicine compared with placebo or usual care in patients with CAD...
2024: Journal of Interventional Cardiology
#9
MULTICENTER STUDY
Daniel Hagemeyer, Anas Merdad, Laura Villegas Sierra, Andrea Ruberti, Faraj Kargoli, Marine Bouchat, Mauro Boiago, Aris Moschovitis, Djeven P Deva, Lukas Stolz, Geraldine Ong, Mark D Peterson, Nicolo Piazza, Maurizio Taramasso, Nicolas Dumonteil, Thomas Modine, Azeem Latib, Fabien Praz, Jörg Hausleiter, Neil P Fam
BACKGROUND: Transcatheter tricuspid valve replacement (TTVR) abolishes tricuspid regurgitation (TR) and has emerged as a definitive treatment for TR. OBJECTIVES: The purpose of this multicenter, observational study was to determine the clinical characteristics and short-term outcomes of patients with TR screened for TTVR. METHODS: Patients underwent TTVR screening at 7 centers on a compassionate-use basis. The primary endpoints were NYHA functional class and TR grade at 30-day follow-up...
February 26, 2024: JACC. Cardiovascular Interventions
#10
JOURNAL ARTICLE
Ali Z Zgheib, Jennifer Jdaidani, Elie Akl, Suzan Khalil, Omar Chaabo, Nicolo Piazza, Fadi J Sawaya, Abdallah G Rebeiz
BACKGROUND: Rates of major bleeding and intraprocedural thrombotic events (IPTE) in the setting of percutaneous coronary intervention (PCI) using weight-adjusted unfractionated heparin (UFH) without activated clotting time (ACT) monitoring are not known. METHODS: We reviewed 2,748 consecutive patients who underwent coronary angiography at our tertiary care university hospital between January 2017 and December 2020. All patients who underwent PCI with weight-adjusted UFH without ACT guidance were considered for further analysis...
2024: International Journal of Clinical Practice
#11
JOURNAL ARTICLE
Xavier Armario, Jennifer Carron, Andrew J Simpkin, Mohamed Elhadi, Ciara Kennedy, Mohamed Abdel-Wahab, Sabine Bleiziffer, Thierry Lefèvre, Alexander Wolf, Thomas Pilgrim, Pedro A Villablanca, Daniel J Blackman, Nicolas M Van Mieghem, Christian Hengstenberg, Martin J Swaans, Bernard D Prendergast, Tiffany Patterson, Marco Barbanti, John G Webb, Miles Behan, Jon Resar, Mao Chen, David Hildick-Smith, Mark S Spence, David Zweiker, Rodrigo Bagur, Rui Teles, Flavio L Ribichini, Dariusz Jagielak, Duk-Woo Park, Ran Kornowski, Joanna J Wykrzykowska, Matjaz Bunc, Rodrigo Estévez-Loureiro, Karl Poon, Matthias Götberg, Raban V Jeger, Hüseyin Ince, Erik J S Packer, Marco Angelillis, Luis Nombela-Franco, Yingqiang Guo, Mikko Savontaus, Abdulrahman M Al-Moghairi, Catalina Andreea Parasca, Chad Kliger, David Roy, Levente Molnár, Mariana Silva, Jonathon White, Masanori Yamamoto, Pedro Carrilho-Ferreira, Stefan Toggweiler, Vassileios Voudris, Yohei Ohno, Inês Rodrigues, Radosław Parma, Soledad Ojeda, Kostas Toutouzas, Ander Regueiro, Marek Grygier, Khaled AlMerri, Ignacio Cruz-González, Viliam Fridrich, José M de la Torre Hernández, Stephane Noble, Petr Kala, Lluis Asmarats, Ibrahim Halil Kurt, Johan Bosmans, Martins Erglis, Ivan Casserly, Dounia Iskandarani, Ravinay Bhindi, Joelle Kefer, Wei-Hsian Yin, Liesbeth Rosseel, Hyo-Soo Kim, Stephen O'Connor, Farrel Hellig, Matias Sztejfman, Oscar Mendiz, Andres M Pineda, Ashok Seth, Elton Pllaha, Fabio S de Brito, Vilhelmas Bajoras, Mohammed A Balghith, Michael Lee, Guering Eid-Lidt, Bert Vandeloo, Vinicius Daher Vaz, Mirvat Alasnag, Gian Paolo Ussia, Edgar Tay, Jorge Mayol, Sengottuvelu Gunasekaran, Gennaro Sardella, Wacin Buddhari, Hsien-Li Kao, Antonio Dager, Apostolos Tzikas, Ingibjörg J Gudmundsdottir, Ahmad Edris, Luis Abel Gutiérrez Jaikel, Eduardo A Arias, Mohammed Al-Hijji, Mehmet Ertürk, César Conde-Vela, Darko Boljević, Adolfo Ferrero Guadagnoli, Toomas Hermlin, Ahmed M ElGuindy, Moysés de Oliveira Lima-Filho, Luciano de Moura Santos, Luis Perez, Gabriel Maluenda, Ali Rıza Akyüz, Imad A Alhaddad, Haitham Amin, Chak-Yu So, Arif A Al Nooryani, Carlos Vaca, Juan Albistur, Quang Ngoc Nguyen, Dabit Arzamendi, Eberhard Grube, Thomas Modine, Didier Tchétché, Kentaro Hayashida, Azeem Latib, Raj R Makkar, Nicolo Piazza, Lars Søndergaard, John William McEvoy, Darren Mylotte
BACKGROUND: The COVID-19 pandemic adversely affected health care systems. Patients in need of transcatheter aortic valve replacement (TAVR) are especially susceptible to treatment delays. OBJECTIVES: The study sought to evaluate the impact of the COVID-19 pandemic on global TAVR activity. METHODS: This international registry reported monthly TAVR case volume in participating institutions prior to and during the COVID-19 pandemic (January 2018 to December 2021)...
December 20, 2023: JACC. Cardiovascular Interventions
#12
JOURNAL ARTICLE
Nicolò Danesin, Alessandro Cellini, Francesco Piazza, Livio Trentin, Andrea Visentin
No abstract text is available yet for this article.
December 22, 2023: Medicina Clínica
#13
JOURNAL ARTICLE
Ali Zgheib, Elie Akl, Marco Spaziano, Giuseppe Martucci, Nicolo Piazza
We report the case of a 64-year-old man with a history of chemotherapy-induced cardiomyopathy requiring heart transplant in 2022 who underwent successful endomyocardial biopsy using patient-specific computed tomographic fluoroscopic projections. ( Level of Difficulty: Beginner. ).
November 15, 2023: JACC. Case reports
#14
JOURNAL ARTICLE
Rosie Fountotos, Sandra Lauck, Nicolo Piazza, Giuseppe Martucci, Rakesh Arora, Anita Asgar, Jessica Forcillo, Remi Kouz, Marino Labinaz, Andre Lamy, Mark Peterson, Harindra Wijeysundera, Lisa Masse, Marie-Claude Ouimet, Jopie Polderman, John Webb, Jonathan Afilalo
BACKGROUND: Despite the high procedural success of transcatheter aortic valve replacement (TAVR), 2 out of 5 older adults report poor physical performance and health-related quality of life (HRQOL) in the ensuing months, particularly those with frailty. There has yet to be a trial examining the synergistic effects of exercise and protein supplementation to counteract frailty and improve patient-centered outcomes following TAVR. METHODS: The PERFORM-TAVR trial is a multicenter parallel-group randomized clinical trial that is enrolling 200 frail older adults ≥70 years undergoing TAVR (NCT03522454)...
December 3, 2023: Canadian Journal of Cardiology
#15
JOURNAL ARTICLE
Nicolo Rossi, Nicola Gigante, Nicola Vitacolonna, Carla Piazza
The field of tumor phylogenetics focuses on studying the differences within cancer cell populations. Many efforts are done within the scientific community to build cancer progression models trying to understand the heterogeneity of such diseases. These models are highly dependent on the kind of data used for their construction, therefore, as the experimental technologies evolve, it is of major importance to exploit their peculiarities. In this work we describe a cancer progression model based on Single Cell DNA Sequencing data...
November 28, 2023: IEEE/ACM Transactions on Computational Biology and Bioinformatics
#16
JOURNAL ARTICLE
Leonhard-Moritz Schneider, Stephen Worthley, Georg Nickenig, Zenon Huczek, Wojtek Wojakowski, Didier Tchetche, Christophe Dubois, Malek Nasr, Luc Verhees, Martin Rothman, Nicolo Piazza, Jean Buithieu, Wen-Loong Yeow, Mirjam Keßler, Wolfgang Rottbauer
BACKGROUND: A significant number of patients with severe mitral regurgitation (MR) are not suitable for either surgical or transcatheter edge-to-edge repair because of high surgical risk or inappropriate mitral valve anatomy. OBJECTIVES: The aim of this study was to evaluate the HighLife Trans-Septal Mitral Valve Replacement (TSMVR) system in patients with symptomatic MR and high surgical risk. METHODS: This prospective, multicenter, nonrandomized feasibility study evaluated the safety and performance of the HighLife TSMVR system in patients with moderate to severe or severe symptomatic MR during 1-year follow-up...
November 16, 2023: JACC. Cardiovascular Interventions
#17
JOURNAL ARTICLE
Francesco Maisano, Nicolo Piazza, Bernard Prendergast, Simon Redwood, Didier Tchétché, Nina C Wunderlich, Pcr London Valves Course Directors
No abstract text is available yet for this article.
November 17, 2023: EuroIntervention
#18
JOURNAL ARTICLE
Nozomi Kotoku, Kai Ninomiya, Daixin Ding, Neil O'Leary, Akihiro Tobe, Kotaro Miyashita, Shinichiro Masuda, Shigetaka Kageyama, Scot Garg, Jonathon A Leipsic, Saima Mushtaq, Daniele Andreini, Kaoru Tanaka, Johan de Mey, William Wijns, Shengxian Tu, Nicolo Piazza, Yoshinobu Onuma, Patrick W Serruys
Murray law-based quantitative flow ratio (µQFR) assesses fractional flow reserve (FFR) in bifurcation lesions using a single angiographic view, enhancing the feasibility of analysis; however, accuracy may be compromised in suboptimal angiographic projections. FFRCT is a well-validated non-invasive method measuring FFR from coronary computed tomographic angiography (CCTA). We evaluated the feasibility of µQFR in left main (LM) bifurcations, the impact of the optimal/suboptimal fluoroscopic view with respect to CCTA, and its diagnostic concordance with FFRCT ...
October 23, 2023: International Journal of Cardiovascular Imaging
#19
JOURNAL ARTICLE
Jingjing He, Tian-Yuan Xiong, Yi-Jun Yao, Yong Peng, Jia-Fu Wei, Zhen-Gang Zhao, Guo Chen, Yuan-Weixiang Ou, Qi Liu, Xi Wang, Zhongkai Zhu, Hao-Ran Yang, Kaiyu Jia, Darren Mylotte, Nicolo Piazza, Bernard Prendergast, Yuan Feng, Mao Chen
BACKGROUND: Data concerning the outcomes of transcatheter aortic valve replacement in type 0 bicuspid aortic stenosis (AS) are scarce. The study aims to compare the outcomes of transcatheter aortic valve replacement for AS in patients with type 0 bicuspid, type 1 bicuspid, and tricuspid aortic valve anatomy. METHODS: We enrolled consecutive patients undergoing transcatheter aortic valve replacement for severe AS between 2012 and 2022 in this single-center retrospective cohort study...
October 17, 2023: Circulation. Cardiovascular Interventions
#20
JOURNAL ARTICLE
Nicolò Danesin, Mariella Lo Schirico, Greta Scapinello, Angela Grassi, Marcello Riva, Tamara Berno, Antonio Branca, Andrea Visentin, Marco Carraro, Laura Pavan, Sabrina Manni, Laura Bonaldi, Annalisa Martines, Roberta Bertorelle, Fabrizio Vianello, Carmela Gurrieri, Chiara Briani, Renato Zambello, Livio Trentin, Francesco Piazza
No abstract text is available yet for this article.
October 2023: HemaSphere
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