Eileen Crowley, Christopher Ma, Leonard Guizzetti, Guangyong Zou, Peter J Lewindon, Michael S Gee, Jeffrey S Hyams, Michael J Rosen, Daniel von Allmen, Anthony de Buck van Overstraeten, Lisa M Shackelton, Julie Remillard, Lauren Schleicher, Jonathan R Dillman, Jordi Rimola, Stuart A Taylor, Joel G Fletcher, Peter C Church, Brian G Feagan, Anne M Griffiths, Vipul Jairath, Mary-Louise C Greer
BACKGROUND: Perianal fistulas and abscesses occur commonly as complications of pediatric Crohn's disease (CD). A validated imaging assessment tool for quantification of perianal disease severity and activity is needed to evaluate treatment response. We aimed to identify magnetic resonance imaging (MRI)-based measures of perianal fistulizing disease activity and study design features appropriate for pediatric patients. METHODS: Seventy-nine statements relevant to MRI-based assessment of pediatric perianal fistulizing CD activity and clinical trial design were generated from literature review and expert opinion...
July 31, 2023: Inflammatory Bowel Diseases