Ewa Gibula-Tarlowska, Volker Korz, Malgorzata Lopatynska-Mazurek, Agnieszka Chlopas-Konowalek, Pawel Grochecki, Predrag Kalaba, Vladimir Dragacevic, Robert Kotlinski, Radosław Kujawski, Michał Szulc, Kamila Czora-Poczwardowska, Przemyslaw L Mikolajczak, Gert Lubec, Jolanta H Kotlinska
Perinatal alcohol exposure can lead to fetal alcohol spectrum disorders (FASD), usually first diagnosed in childhood, that are characterized by hyperactivity, impulsivity and learning and memory disability, among others. To test the hypothesis that dopamine signaling is one of the main factors underlying these impairments, a new atypical dopamine transporter (DAT) inhibitor, CE-123 (1, 3 or 10 mg/kg) was assessed for its potential to overcome the ethanol-induced behavioral effects in a rat model of FASD. In the present study, neonatal rats were exposed to alcohol intubations across the neonatal period (postnatal day (PND)4-9, the third trimester equivalent of human gestation) and, after weaning, the animals (male rats) were assigned randomly to three groups...
April 30, 2021: Behavioural Brain Research