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JOURNAL ARTICLE
Miguel A Vicente-Querol, Antonio Fernández-Caballero, Pascual González, Luz M González-Gualda, Patricia Fernández-Sotos, José P Molina, Arturo S García
Facial affect recognition is a critical skill in human interactions that is often impaired in psychiatric disorders. To address this challenge, tests have been developed to measure and train this skill. Recently, virtual human (VH) and virtual reality (VR) technologies have emerged as novel tools for this purpose. This study investigates the unique contributions of different factors in the communication and perception of emotions conveyed by VHs. Specifically, it examines the effects of the use of action units (AUs) in virtual faces, the positioning of the VH (frontal or mid-profile), and the level of immersion in the VR environment (desktop screen versus immersive VR)...
October 2023: International Journal of Neural Systems
#22
JOURNAL ARTICLE
Carlos Montañez-Molina, Javier Pliego-Jiménez, Rigoberto Martínez-Clark
In this work, we study the problem of designing control laws that achieve time-varying formation and flocking behaviors in robot networks where each agent or robot presents double integrator dynamics. To design the control laws, we adopt a hierarchical control approach. First, we introduce a virtual velocity, which is used as a virtual control input for the position subsystem (outer loop). The objective of the virtual velocity is to achieve collective behaviors. Then, we design a velocity tracking control law for the velocity subsystem (inner loop)...
May 23, 2023: Entropy
#23
JOURNAL ARTICLE
G Christiaens, M Defurne, D Sokhan, P Achenbach, Z Akbar, M J Amaryan, H Atac, H Avakian, C Ayerbe Gayoso, L Baashen, N A Baltzell, L Barion, M Bashkanov, M Battaglieri, I Bedlinskiy, B Benkel, F Benmokhtar, A Bianconi, A S Biselli, M Bondi, W A Booth, F Bossù, S Boiarinov, K-Th Brinkmann, W J Briscoe, S Bueltmann, D Bulumulla, V D Burkert, T Cao, D S Carman, J C Carvajal, A Celentano, P Chatagnon, V Chesnokov, T Chetry, G Ciullo, G Clash, P L Cole, M Contalbrigo, G Costantini, A D'Angelo, N Dashyan, R De Vita, A Deur, S Diehl, C Dilks, C Djalali, R Dupre, H Egiyan, M Ehrhart, A El Alaoui, L El Fassi, L Elouadrhiri, S Fegan, A Filippi, K Gates, G Gavalian, Y Ghandilyan, G P Gilfoyle, F X Girod, D I Glazier, A A Golubenko, G Gosta, R W Gothe, Y Gotra, K A Griffioen, M Guidal, K Hafidi, H Hakobyan, M Hattawy, F Hauenstein, T B Hayward, D Heddle, A Hobart, D E Holmberg, M Holtrop, Y Ilieva, D G Ireland, E L Isupov, H S Jo, D Keller, M Khachatryan, A Khanal, W Kim, A Kripko, V Kubarovsky, S E Kuhn, V Lagerquist, L Lanza, M L Kabir, M Leali, S Lee, P Lenisa, X Li, K Livingston, I J D MacGregor, D Marchand, V Mascagna, G Matousek, B McKinnon, C McLauchlin, Z E Meziani, S Migliorati, R G Milner, T Mineeva, M Mirazita, V Mokeev, E Molina, C Munoz Camacho, P Nadel-Turonski, P Naidoo, K Neupane, S Niccolai, M Nicol, G Niculescu, M Osipenko, M Ouillon, P Pandey, M Paolone, L L Pappalardo, R Paremuzyan, E Pasyuk, S J Paul, W Phelps, N Pilleux, M Pokhrel, J Poudel, J W Price, Y Prok, A Radic, N Ramasubramanian, B A Raue, Trevor Reed, J Richards, M Ripani, J Ritman, P Rossi, F Sabatié, C Salgado, S Schadmand, A Schmidt, M B C Scott, Y G Sharabian, E V Shirokov, U Shrestha, P Simmerling, N Sparveris, M Spreafico, S Stepanyan, I I Strakovsky, S Strauch, J A Tan, N Trotta, M Turisini, R Tyson, M Ungaro, S Vallarino, L Venturelli, H Voskanyan, E Voutier, D P Watts, X Wei, R Williams, R Wishart, M H Wood, N Zachariou, J Zhang, Z W Zhao, V Ziegler, M Zurek
Deeply virtual Compton scattering (DVCS) allows one to probe generalized parton distributions describing the 3D structure of the nucleon. We report the first measurement of the DVCS beam-spin asymmetry using the CLAS12 spectrometer with a 10.2 and 10.6 GeV electron beam scattering from unpolarized protons. The results greatly extend the Q^{2} and Bjorken-x phase space beyond the existing data in the valence region and provide 1600 new data points measured with unprecedented statistical uncertainty, setting new, tight constraints for future phenomenological studies...
May 26, 2023: Physical Review Letters
#24
JOURNAL ARTICLE
Maria Carmen Rodenas, Julia Peñas-Martínez, Irene Pardo-Sánchez, David Zaragoza-Huesca, Carmen Ortega-Sabater, Jorge Peña-García, Salvador Espín, Guillermo Ricote, Sofía Montenegro, Francisco Ayala-De La Peña, Ginés Luengo-Gil, Andrés Nieto, Francisco García-Molina, Vicente Vicente, Francesco Bernardi, María Luisa Lozano, Victoriano Mulero, Horacio Pérez-Sánchez, Alberto Carmona-Bayonas, Irene Martínez-Martínez
Introduction: Hepsin is a type II transmembrane serine protease and its expression has been linked to greater tumorigenicity and worse prognosis in different tumors. Recently, our group demonstrated that high hepsin levels from primary tumor were associated with a higher risk of metastasis and thrombosis in localized colorectal cancer patients. This study aims to explore the molecular role of hepsin in colorectal cancer. Methods: Hepsin levels in plasma from resected and metastatic colorectal cancer patients were analyzed by ELISA...
2023: Frontiers in Molecular Biosciences
#25
Ainhoa Molina-Martín, Luis Leal-Vega, Dolores de Fez, Elena Martínez-Plaza, María Begoña Coco-Martín, David P Piñero
The use of digital devices provides a wide range of possibilities for measuring and improving visual function, including concepts such as perceptual learning and dichoptic therapy. Different technologies can be used to apply these concepts, including, in recent years, the introduction of virtual reality (VR) systems. A preliminary experience in treating anisometropic amblyopia through an immersive VR device and using prototype software is described. A total of 4 children were treated by performing 18 office-based sessions...
May 19, 2023: Vision
#26
JOURNAL ARTICLE
Rosbel Toledo-Ortiz, Jessica Margarita González-Rojas, Luis Enrique Molina-Vallejo, José Javier Mendoza-Velásquez, Yesenia Romero-Casillas, Luz Alejandra Cano-Collado, Sergio Aarón de la Rosa-Cruz, Carlos Alberto Juárez-Medel, César Raúl González-Bonilla
The Institute for Health for Well-being (INSABI according to its initials in Spanish), in collaboration with the National Institute of Medical Sciences and Nutrition Salvador Zubirán (INCMNSZ), instituted the Continuous Training on clinical management "Mexico against COVID-19" in 2020, with the purpose of training the frontline health personnel in the care for patients with COVID-19 in the context of hospital reconversion through the COVIDUTI platform. Virtual conferences were held for medical personnel from all over the country with the possibility of interacting with various specialists...
May 2, 2023: Revista Médica del Instituto Mexicano del Seguro Social
#27
JOURNAL ARTICLE
Patricia Ablanedo Morales, Brittany R Rodriguez, Michael E Furth, Kayla B Molina, Andrew J Boland, Jonathon E Mohl, Thomas Boland
Since the first description of inkjet bioprinting (TIB) of cells in 2003, quantifying the input and measuring the output of the printers has been the hallmark of the field of bioprinting, as it is virtually impossible to characterize cells that are inside the printing orifices or extrusion needles. We will describe here some recent discoveries of cell behavior due to inkjet bioprinting. 
Primary and immortalized adult dermal fibroblasts were expanded for 2-3 passages upon receiving. The cells were harvested, resuspended in PBS, and bioprinted into a 96-well plate with pluriSTEM media...
May 9, 2023: Biofabrication
#28
REVIEW
Elia Lacchini, Jhon Venegas-Molina, Alain Goossens
Metabolic enzymes tend to evolve towards catalytic efficacy, precision and speed. This seems particularly true for ancient and conserved enzymes involved in fundamental cellular processes that are present virtually in every cell and organism and converting and producing relatively limited metabolite numbers. Nevertheless, sessile organisms like plants have an astonishing repertoire of specific (specialized) metabolites that, by numbers and chemical complexity, by far exceed primary metabolites. Most theories agree that early gene duplication, subsequent positive selection and diversifying evolution have allowed relaxed selection of duplicated metabolic genes, thus facilitating the accumulation of mutations that could broaden substrate/product specificity and lower activation barriers and kinetics...
May 4, 2023: Current Opinion in Plant Biology
#29
JOURNAL ARTICLE
Alberto Pino-Postigo, Dolores Domínguez-Pinos, Rocío Lorenzo-Alvarez, José Pavía-Molina, Miguel J Ruiz-Gómez, Francisco Sendra-Portero
BACKGROUND: The objective of this study was to conduct a clinical session meeting in the virtual world of Second Life to improve the oral presentation skills of radiology residents and to assess the perception of the attendees. METHODS: A clinical session meeting (10 two-hour sessions over four weeks), where participants presented their own clinical sessions, followed by a turn of interventions by the attendees, was designed and carried out. Attendees were asked to complete an evaluation questionnaire...
March 8, 2023: International Journal of Environmental Research and Public Health
#30
JOURNAL ARTICLE
Juliana Magalhães da Silva, Michelle Didone Dos Santos, Raquel Quimas Molina da Costa, Emerson Galves Moretto, Larissa Alamino Pereira de Viveiro, Roseli de Deus Lopes, Sonia Maria Dozzi Brucki, José Eduardo Pompeu
BACKGROUND: Spatial orientation is a cognitive domain frequently compromised in patients with Alzheimer disease (AD) and may be one of its first clinical manifestations. Some studies have shown that allocentric integration with egocentric spatial information seems to be impaired in this pathology. There is no consensus on how best to assess spatial orientation and traditional tests lack ecological validity, but, recently, virtual reality (VR) has provided new opportunities for this assessment...
January 2023: Arquivos de Neuro-psiquiatria
#31
JOURNAL ARTICLE
Yasodha Natkunam, Daphne de Jong, Pedro Farinha, Philippe Gaulard, Wolfram Klapper, Andreas Rosenwald, Birgitta Sander, Reuben Tooze, Ranjana Advani, Catherine Burton, John G Gribben, Marie-José Kersten, Eva Kimby, Georg Lenz, Thierry Molina, Franck Morschhauser, David Scott, Laurie Sehn, Wendy Stevens, Andrew Clear, Maryse Baia, Abdelmalek Habi, Mad-Helenie Elsensohn, Carole Langlois-Jacques, Delphine Maucort-Boulch, Maria Calaminici
AIMS: Subclassification of large B-cell lymphoma (LBCL) is challenging due to the overlap in histopathologic, immunophenotypic, and genetic data. In particular, the criteria to separate diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma (HGBL) are difficult to apply in practice. The Lunenburg Lymphoma Biomarker Consortium previously reported a cohort of over 5000 LBCL that included fluorescent in situ hybridization (FISH) data. This cohort contained 209 cases with MYC rearrangement that were available for a validation study of how various histopathological features are used by a panel of eight expert hematopathologists...
February 27, 2023: Histopathology
#32
JOURNAL ARTICLE
Sheila Cruz Araujo, Rafaela Molina de Angelo, Henrique Barbosa, Thais Alves Costa-Silva, André Gustavo Tempone, João Henrique Ghilardi Lago, Kathia Maria Honorio
Chagas disease, after more than a century after its discovery, is still a major public health problem. It is estimated that approximately 10 million people worldwide are infected with T. cruzi. However, the situation is more critical in Latin America and other regions where the disease is endemic. The largest number of cases occurs in Brazil, Argentina, and Mexico as more than 100 million people in these regions are located in areas with a high risk of contamination by the vector. The need for new therapeutic alternatives is urgent, as the available drugs have severe limitations such as low efficacy and high toxicity...
December 31, 2022: European Journal of Medicinal Chemistry
#33
REVIEW
Ignasi Puch-Giner, Alexis Molina, Martí Municoy, Carles Pérez, Victor Guallar
Computer simulation techniques are gaining a central role in molecular pharmacology. Due to several factors, including the significant improvements of traditional molecular modelling, the irruption of machine learning methods, the massive data generation, or the unlimited computational resources through cloud computing, the future of pharmacology seems to go hand in hand with in silico predictions. In this review, we summarize our recent efforts in such a direction, centered on the unconventional Monte Carlo PELE software and on its coupling with machine learning techniques...
December 17, 2022: International Journal of Molecular Sciences
#34
JOURNAL ARTICLE
Erwin Hernando Hernández Rincón, Rafael Tuesca Molina, Eduardo Guerrero Espinel, Henry Gutiérrez González, Nelson Agudelo, Gabriel Listovsky
Objective: Reconstruct the experience of the Virtual Campus for Public Health (VCPH) from 2012 to 2019 in Colombia. Methods: The experience of public health training through the VCPH in Colombia in the period 2012-2019 was systematized. The information is presented in cross-section time series to show the evolution of the VCPH in Colombia over time. Results: A total of 2 627 health professionals took tutored courses and 34 012 followed self-learning courses on relevant, up-to-date, priority public health issues...
2022: Pan American Journal of Public Health
#35
JOURNAL ARTICLE
Gerardo Tibamoso-Pedraza, Sarah Amouri, Victor Molina, Iñaki Navarro, Marie-Josée Raboisson, Joaquim Miró, Chantale Lapierre, Sylvie Ratté, Luc Duong
PURPOSE: Transesophageal echocardiography (TEE) is the preferred imaging modality in a hybrid procedure used to close ventricular septal defects (VSDs). However, the limited field of view of TEE hinders the maneuvering of surgical instruments inside the beating heart. This study evaluates the accuracy of a method that aims to support navigation guidance in the hybrid procedure. METHODS: A cardiologist maneuvered a needle to puncture the patient's heart and to access a VSD, guided by information displayed in a virtual environment...
July 7, 2022: International Journal of Computer Assisted Radiology and Surgery
#36
JOURNAL ARTICLE
Michelle Didone Dos Santos, Juliana Magalhães da Silva, Raquel Quimas Molina da Costa, Larissa Alamino Pereira de Viveiro, Emerson Galves Moretto, Roseli de Deus Lopes, Sonia Maria Dozzi Brucki, José Eduardo Pompeu
Spatial orientation is defined as the ability to find one's way around an environment, follow familiar routes, recognize places, and learn new routes. Spatial disorientation is one of the early symptoms of Alzheimer's disease (AD), and traditional cognitive evaluation lacks ecological validity. Therefore, new assessment methods are needed for the early identification of this cognitive impairment. Objective: This study aimed to compare the applicability and stability of an immersive virtual reality (VR) system developed to assess route learning between older adults with and without mild cognitive impairment (MCI)...
April 2022: Dementia & Neuropsychologia
#37
JOURNAL ARTICLE
Miguel A Vicente-Querol, Antonio Fernández-Caballero, José P Molina, Luz M González-Gualda, Patricia Fernández-Sotos, Arturo S García
The recognition of facial expression of emotions in others is essential in daily social interactions. The different areas of the face play different roles in decoding each emotion. To find out which ones are more important, the traditional approach has been to use eye-tracking devices with static pictures to capture which parts of the face people are looking at when decoding emotions. However, the ecological validity of this approach is limited because, unlike in real life, there is no movement in the face that can be used to identify the emotion...
October 2022: International Journal of Neural Systems
#38
JOURNAL ARTICLE
C Cuenca-Barrales, A Molina-Leyva, D Moreno-Ramírez, P de la Cueva, Y Gilaberte, S Arias-Santiago
BACKGROUND AND OBJECTIVE: No recent data on health care resources and medical and surgical activity in Spanish dermatology departments are available in the literature. The aim of this study was to compile this information for 2019. MATERIAL AND METHODS: Cross-sectional study based on an online survey sent to the heads of dermatology departments at public hospitals in Spain. RESULTS: Of the 162 department heads contacted, 59 answered the survey (participation rate, 36...
May 2022: Actas Dermo-sifiliográficas
#39
JOURNAL ARTICLE
L Leal Vega, D P Piñero, C J Hernández Rodríguez, A Molina Martín, L Morales-Quezada, A I Vallelado Álvarez, J F Arenillas Lara, M B Coco Martín
BACKGROUND: Interest in developing alternative methods for the treatment of amblyopia has long been a topic of interest among clinicians and researchers, as prescribed occlusion and penalization therapies do not always provide an effective response and are associated with a high risk of recurrence and non-compliance. Here, we present the protocol of a small-scale RCT to evaluate the safety and clinical efficacy of a novel VR-based system designed to provide binocular vision training to children with anisometropic amblyopia...
June 7, 2022: BMC Ophthalmology
#40
JOURNAL ARTICLE
Sandra Romero-Molina, Yasser B Ruiz-Blanco, Joel Mieres-Perez, Mirja Harms, Jan Münch, Michael Ehrmann, Elsa Sanchez-Garcia
Virtual screening of protein-protein and protein-peptide interactions is a challenging task that directly impacts the processes of hit identification and hit-to-lead optimization in drug design projects involving peptide-based pharmaceuticals. Although several screening tools designed to predict the binding affinity of protein-protein complexes have been proposed, methods specifically developed to predict protein-peptide binding affinity are comparatively scarce. Frequently, predictors trained to score the affinity of small molecules are used for peptides indistinctively, despite the larger complexity and heterogeneity of interactions rendered by peptide binders...
August 5, 2022: Journal of Proteome Research
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