Keywords high resolution magnetic reson...

high resolution magnetic resonance imaging
Ali F Khan, Fan Zhang, Han Yuan, Lei Ding
OBJECTIVE: Diffuse optical tomography (DOT) has the potential in reconstructing resting-state networks (RSNs) in human brains with high spatio-temporal resolutions and multiple contrasts. While several RSNs have been reported and successfully reconstructed using DOT, its full potential in recovering a collective set of distributed brain-wide networks with the number of RSNs close to those reported using functional magnetic resonance imaging (fMRI) has not been demonstrated. APPROACH: The present study developed a novel brain-wide DOT (BW-DOT) framework that integrates a cap-based whole-head optode placement system with multiple computational approaches, i...
May 4, 2021: Journal of Neural Engineering
Yuna Li, Tongpeng Chu, Kaili Che, Fanghui Dong, Yinghong Shi, Heng Ma, Feng Zhao, Ning Mao, Haizhu Xie
BACKGROUND: Postpartum depression (PPD) is a serious postpartum mental health problem worldwide. However, the cortical structural alterations in patients with PPD remain unclear. This study investigated the cortical structural alterations of PPD patients through multidimensional structural patterns and their potential correlations with clinical severity. METHODS: High-resolution 3D T1 structural images were acquired from 21 drug-naive patients with PPD and 18 healthy postpartum women matched for age, educational level, and body mass index...
May 1, 2021: Behavioural Brain Research
Ru Kong, Qing Yang, Evan Gordon, Aihuiping Xue, Xiaoxuan Yan, Csaba Orban, Xi-Nian Zuo, Nathan Spreng, Tian Ge, Avram Holmes, Simon Eickhoff, B T Thomas Yeo
Resting-state functional magnetic resonance imaging (rs-fMRI) allows estimation of individual-specific cortical parcellations. We have previously developed a multi-session hierarchical Bayesian model (MS-HBM) for estimating high-quality individual-specific network-level parcellations. Here, we extend the model to estimate individual-specific areal-level parcellations. While network-level parcellations comprise spatially distributed networks spanning the cortex, the consensus is that areal-level parcels should be spatially localized, that is, should not span multiple lobes...
May 4, 2021: Cerebral Cortex
Andrei Lebovici, Csaba Csutak, Paula Popa, Nicolae Crișan, Mihai Suciu, Bogdan Feciche, Iulia Andraș, Paul-Andrei Ștefan, Diana Sorina Feier
BACKGROUND: The magnetic resonance (MRI) diagnosis of chronic prostatitis (CP) is insufficiently evaluated. PURPOSE: To evaluate the MRI appearance of CP in young patients by comparing it to individuals with non-prostatic related pathology. MATERIAL AND METHODS: The study included 47 patients with prostatitis-like symptoms evaluated by urologists and referred to pelvic MRI examination (mean age=40.23±7 years; age range=23-49 years) and 93 age-matched individuals with non-prostatic related pathology (mean age=37...
May 3, 2021: Acta Radiologica
Erpeng Dai, Simin Liu, Hua Guo
High-resolution diffusion MRI (dMRI) is a crucial tool in neuroscience studies to detect fine fiber structure, depict complex fiber architecture and analyze cortical anisotropy. However, high-resolution dMRI is limited by its intrinsically low SNR due to diffusion attenuation. A series of techniques have been proposed to improve the SNR performance, but most of them are at the cost of long scan time, which in turn sacrifice the SNR efficiency, especially for large FOV imaging, such as whole-brain imaging. Recently, a combination of 3D multi-slab acquisition and simultaneous multi-slice (SMS) excitation, namely simultaneous multi-slab (SMSlab), has been demonstrated to have potential for high-resolution diffusion imaging with high SNR and SNR efficiency...
April 30, 2021: NeuroImage
Merlijn C E van der Plas, Sophie Schmid, Maarten J Versluis, Thomas W Okell, Matthias J P van Osch
The objective of the current study was to combine a time-encoded pseudocontinuous arterial spin labeling (te-pCASL) scheme with a golden angle radial readout for simultaneous acquisition of angiography and perfusion images from one single dataset, both in a highly flexible single-slice approach as well as within a multislice setting. A te-pCASL preparation and the golden angle radial readout were both used as a temporal resolution tool to retrospectively choose the temporal window for the reconstruction of both angiography and perfusion images from a single-slice dataset...
May 3, 2021: NMR in Biomedicine
Hae Jin Kim, Yeon Hyeon Choe, Sung Mok Kim, Eun Kyung Kim, Mirae Lee, Sung Ji Park, Joonghyun Ahn, Keumhee C Carriere
OBJECTIVE: We aimed to compare the aortic valve area (AVA) calculated using fast high-resolution three-dimensional (3D) magnetic resonance (MR) image acquisition with that of the conventional two-dimensional (2D) cine MR technique. MATERIALS AND METHODS: We included 139 consecutive patients (mean age ± standard deviation [SD], 68.5 ± 9.4 years) with aortic valvular stenosis (AS) and 21 asymptomatic controls (52.3 ± 14.2 years). High-resolution T2-prepared 3D steady-state free precession (SSFP) images (2...
April 23, 2021: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Alexandre Samouilov, Denis Komarov, Sergey Petryakov, Arkadiy Iosilevich, Jay L Zweier
PURPOSE: To develop a novel resonator for high-quality fast scan electron paramagnetic resonance (EPR) and EPR/NMR co-imaging of the head and brain of mice at 1.25 GHz. METHODS: Resonator dimensions were scaled to fit the mouse head with maximum filling factor. A single-loop 6-gap resonator of 20 mm diameter and 20 mm length was constructed. High resonator stability was achieved utilizing a fixed position double coupling loop. Symmetrical mutually inverted connections rendered it insensitive to field modulation and fast scan...
May 3, 2021: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Khaoula Bouazizi, Mohamed Zarai, Florian Marquet, Judith Aron-Wisnewsky, Karine Clément, Alban Redheuil, Nadjia Kachenoura
To determine whether magnetic resonance imaging (MRI) when used in an optimal ex vivo setting can help detecting and quantifying the 3D fibrosis fraction in human subcutaneous adipose tissue (SAT) samples, as compared to histology. This prospective observational study was approved by our institutional review board 3D MRI acquisitions were performed at 4.0 T (Bruker) on XX human SAT samples (around 1 cm3) collected from biopsy in morbidly obese patients. Such acquisitions included saturation-recovery T1 mapping (spatial resolution: 200 µm, acquisition time: ~16 minutes) and DIXON imaging (spatial resolution: 200 µm, acquisition time: ~20 minutes)...
May 2021: Quantitative Imaging in Medicine and Surgery
Zhenxing Huang, Gen Li, Zhenye Li, Shengjun Sun, Yazhuo Zhang, Zonggang Hou, Jian Xie
Neuroplasticity may preserve neurologic function in insular glioma, thereby improving prognosis following resection. However, the anatomic and molecular bases of this phenomenon are not known. To address this gap in knowledge, the present study investigated contralesional compensation in different molecular pathologic subtypes of insular glioma by high-resolution three-dimensional T1-weighted structural magnetic resonance imaging. A total of 52 patients with insular glioma were examined. We compared the gray matter volume (GMV) of the contralesional insula according to histological grade [low-grade glioma (LGG) and high-grade glioma (HGG)] and molecular pathology status [isocitrate dehydrogenase (IDH) mutation, telomerase reverse-transcriptase ( TERT ) promoter mutation, and 1p19q codeletion] by voxel-based morphometry (VBM)...
2021: Frontiers in Neurology
Changchun He, Jesus M Cortes, Xiaodong Kang, Jing Cao, Heng Chen, Xiaonan Guo, Ruishi Wang, Lingyin Kong, Xinyue Huang, Jinming Xiao, Xiaolong Shan, Rui Feng, Huafu Chen, Xujun Duan
Individual-based morphological brain networks built from T1-weighted magnetic resonance imaging (MRI) reflect synchronous maturation intensities between anatomical regions at the individual level. Autism spectrum disorder (ASD) is a socio-cognitive and neurodevelopmental disorder with high neuroanatomical heterogeneity, but the specific patterns of morphological networks in ASD remain largely unexplored at the individual level. In this study, individual-based morphological networks were constructed by using high-resolution structural MRI data from 40 young children with ASD (age range: 2-8 years) and 38 age-, gender-, and handedness-matched typically developing children (TDC)...
May 2, 2021: Human Brain Mapping
Stefan Soellner, Goetz Hannes Welsch, Kolja Gelse, Axel Goldmann, Arnd Kleyer, Georg Schett, Milena L Pachowsky
OBJECTIVE: The aim of this study was to compare glycosaminoglycan chemical exchange saturation transfer (gagCEST) of knee cartilage with intraoperative results for the assessment of early osteoarthritis (OA) and to define gagCEST values for the differentiation between healthy and degenerated cartilage. DESIGN: Twenty-one patients with cartilage lesions or moderate OA were examined using 3T Magnetic Resonance Imaging (MRI). In this prospective study, regions of interest (ROIs) were examined by a sagittal gagCEST analysis and a morphological high-resolution three-dimensional, fat-saturated proton-density space sequence...
April 29, 2021: Osteoarthritis and Cartilage
Francesco Giganti, Alex Kirkham, Veeru Kasivisvanathan, Marianthi-Vasiliki Papoutsaki, Shonit Punwani, Mark Emberton, Caroline M Moore, Clare Allen
Prostate magnetic resonance imaging (MRI) of high diagnostic quality is a key determinant for either detection or exclusion of prostate cancer. Adequate high spatial resolution on T2-weighted imaging, good diffusion-weighted imaging and dynamic contrast-enhanced sequences of high signal-to-noise ratio are the prerequisite for a high-quality MRI study of the prostate. The Prostate Imaging Quality (PI-QUAL) score was created to assess the diagnostic quality of a scan against a set of objective criteria as per Prostate Imaging-Reporting and Data System recommendations, together with criteria obtained from the image...
May 1, 2021: Insights Into Imaging
Xingxing Yang, Chao Song, Lei Zhang, Junjun Wang, Xin Yu, Biao Yu, Vitalii Zablotskii, Xin Zhang
Studies have shown that 9.4 Tesla (9.4 T) high-field magnetic resonance imaging (MRI) has obvious advantages in improving image resolution and capacity, but their safety issues need to be further validated before their clinical approval. Meanwhile, emerging experimental evidences show that moderate to high intensity Static Magnetic Fields (SMFs) have some anti-cancer effects. We examined the effects of two opposite SMF directions on lung cancer bearing mice and found when the lung cancer cell-bearing mice were treated with 9...
April 27, 2021: Translational Oncology
Rongrong Jin, Wencheng Zhu, Gan Lin, Gang Liu, Hua Ai
Visualizing siRNA delivery through medical imaging methods has drawn much attentions in recent gene therapy studies. Among them, iron oxide-based magnetic resonance imaging (MRI) is regarded as one of the most promising imaging modalities for its high spatial resolution as well as deep penetration and real-time properties. In this chapter, a detailed protocol of an amphiphilic superparamagnetic iron oxide (SPIO) nanovehicle-based siRNA delivery is described, mainly focusing on SPIO/siRNA complexes formation and characterization, in vitro and in vivo siRNA delivery, MRI study of the delivery and transfection efficiency evaluation...
2021: Methods in Molecular Biology
Kavita Singh, María Guadalupe García-Gomar, Marta Bianciardi
INTRODUCTION: The mesencephalic reticular formation, isthmic reticular formation, microcellular tegmental nucleus, ventral tegmental area nuclei and linear raphe nuclei are small brainstem regions crucially involved in arousal, sleep, and reward. Yet, these nuclei are difficult to identify in magnetic resonance imaging (MRI) of living humans. In the current work we developed a probabilistic atlas of these brainstem nuclei in living humans, using non-invasive ultra-high field MRI. METHODS: In 12 healthy subjects we acquired single-subject multi-contrast (diffusion and T2-weighted) 1...
April 30, 2021: Brain Connectivity
Marta Orts-Arroyo, Amadeo Ten-Esteve, Sonia Ginés-Cárdenas, Isabel Castro, Luis Martí-Bonmatí, José Martínez-Lillo
The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)2 (H2 O)6 ](ClO4 )3 ·2H2 O ( 1 ) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase...
April 27, 2021: International Journal of Molecular Sciences
Hongtao Zhang, Yuki Shinomiya, Shinichi Yoshida
The diagnosis of brain pathologies usually involves imaging to analyze the condition of the brain. Magnetic resonance imaging (MRI) technology is widely used in brain disorder diagnosis. The image quality of MRI depends on the magnetostatic field strength and scanning time. Scanners with lower field strengths have the disadvantages of a low resolution and high imaging cost, and scanning takes a long time. The traditional super-resolution reconstruction method based on MRI generally states an optimization problem in terms of prior information...
April 23, 2021: Sensors
Martina Lucignani, Daniela Longo, Elena Fontana, Maria Camilla Rossi-Espagnet, Giulia Lucignani, Sara Savelli, Stefano Bascetta, Stefania Sgrò, Francesco Morini, Paola Giliberti, Antonio Napolitano
Congenital diaphragmatic hernia (CDH) is a severe pediatric disorder with herniation of abdominal viscera into the thoracic cavity. Since neurodevelopmental impairment constitutes a common outcome, we performed morphometric magnetic resonance imaging (MRI) analysis on CDH infants to investigate cortical parameters such as cortical thickness (CT) and local gyrification index (LGI). By assessing CT and LGI distributions and their correlations with variables which might have an impact on oxygen delivery (total lung volume, TLV), we aimed to detect how altered perfusion affects cortical development in CDH...
April 2, 2021: Brain Sciences
Martin Freesmeyer, Julia Greiser, Thomas Winkens, Falk Gühne, Christian Kühnel, Falk Rauchfuß, Hans-Michael Tautenhahn, Robert Drescher
Established imaging modalities for the characterization of liver tumors are computed tomography (CT), magnetical resonance (MR) imaging, sonography, and hepatobiliary scintigraphy. In some cases, their results may be inconclusive or certain examinations not possible due to contraindications. Positron emission tomography (PET)/CT has the capability of dynamic imaging with high temporal resolution. With radiolabeled tri-alkoxysalicyl-1,4-diazepan-6-amine (TAoS-DAZA) tracers, imaging of liver perfusion and hepatobiliary function is possible in a single examination...
April 6, 2021: Diagnostics
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