high resolution magnetic resonance imaging

Ethan Bendau, Jason Smith, Lin Zhang, Ellen Ackerstaff, Natalia Kruchevsky, Binlin Wu, Jason A Koutcher, Robert Alfano, Lingyan Shi
Triple-negative breast cancer (TNBC) is an aggressive subset of breast cancer that is more common in African-American and Hispanic women. Early detection followed by intensive treatment is critical to improving poor survival rates. The current standard to diagnose TNBC from histopathology of biopsy samples is invasive and time-consuming. Imaging methods such as mammography and magnetic resonance (MR) imaging, while covering the entire breast, lack the spatial resolution and specificity to capture the molecular features that identify TNBC...
March 26, 2020: Journal of Biophotonics
Jelle A van Dijk, Alessio Fracasso, Natalia Petridou, Serge O Dumoulin
A fundamental assumption of nearly all functional magnetic resonance imaging (fMRI) analyses is that the relationship between local neuronal activity and the blood oxygenation level dependent (BOLD) signal can be described as following linear systems theory. With the advent of ultra-high field (7T and higher) MRI scanners, it has become possible to perform sub-millimeter resolution fMRI in humans. A novel and promising application of sub-millimeter fMRI is measuring responses across cortical depth, i.e. laminar imaging...
March 25, 2020: Scientific Reports
Vishwesh Nath, Kurt G Schilling, Samuel Remedios, Roza G Bayrak, Yurui Gao, Justin A Blaber, Yuankai Huo, Bennett A Landman, A W Anderson
Histological analysis is typically the gold standard for validating measures of tissue microstructure derived from magnetic resonance imaging (MRI) contrasts. However, most histological investigations are inherently 2-dimensional (2D), due to increased field-of-view, higher in-plane resolutions, ease of acquisition, decreased costs, and a large number of available contrasts compared to 3-dimensional (3D) analysis. Because of this, it would be of great interest to be able to learn the 3D tissue microstructure from 2D histology...
April 2019: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
Xuejing Li, Ling Wang, Qian Chen, Yongsheng Hu, Jubao Du, Xin Chen, Weimin Zheng, Jie Lu, Nan Chen
Objective: To investigate the reorganization of insular subregions in individuals suffering from neuropathic pain (NP) after incomplete spinal cord injury (ISCI) and further to disclose the underlying mechanism of NP. Method: The 3D high-resolution T1-weighted structural images and resting-state functional magnetic resonance imaging (rs-fMRI) of all individuals were obtained using a 3.0 Tesla MRI system. A comparative analysis of structure and function connectivity (FC) with insular subareas as seeds in 10 ISCI individuals with below-level NP (ISCI-P), 11 ISCI individuals without NP (ISCI-N), and 25 healthy controls (HCs) was conducted...
2020: Neural Plasticity
Jie Liu, Liang Jing Cheng, Yong Zhang, Tao Hong Song, Jian Wei Wang
Hemangiomas are relatively rare tumors representing approximately 0.4% of all the salivary gland tumors and occur predominantly in the parotid. Most of the hemangiomas appear during the first year of life; however, are uncommon in adults. Moreover, the rich fat hemangiomas in the parotid are extremely rare. Magnetic resonance imaging is the most important radiologic methods for the diagnosis of the disease as its high resolution of soft tissue which helps to show the relationship with the adjacent structures...
March 20, 2020: Journal of Craniofacial Surgery
Hidenobu Tachibana, Yusuke Watanabe, Shinya Mizukami, Takuya Maeyama, Tsuyoshi Terazaki, Ryuzo Uehara, Tetsuo Akimoto
PURPOSE: The purpose of this study was to develop a novel quality assurance (QA) program to check the entire treatment chain of image-guided brachytherapy with dose distribution evaluation in a single setup and irradiation using a gel dosimeter. METHODS AND MATERIALS: A polymer gel was used, and the readout was performed by magnetic resonance scanning. A CT-based treatment plan was generated using the Oncentra planning system (Elekta, Sweden), and irradiation was performed three times using an afterloading device with an Ir-192 source...
March 21, 2020: Brachytherapy
Hadi Borjkhani, Seyed Kamaledin Setarehdan
Recent advances in optical neuroimaging systems as a functional interface enhance our understanding of neuronal activity in the brain. High density diffuse optical topography (HD-DOT) uses multi-distance overlapped channels to improve the spatial resolution of images comparable to functional magnetic resonance imaging (fMRI). The topology of the source and detector (SD) array directly impacts the quality of the hemodynamic reconstruction in HD-DOT imaging modality. In this work, the effect of different SD configurations on the quality of cerebral hemodynamic recovery is investigated by presenting a simulation setup based on the analytical approach...
2020: PloS One
Giuseppe Quero, Claudio Fiorillo, Bernard Dallemagne, Pietro Mascagni, Jelena Curcic, Mark Fox, Silvana Perretta
BACKGROUND: The incidence of de novo gastroesophageal reflux disease (GERD) after LSG is substantial. However, an objective correlation with the structural gastric and EGJ changes has not been demonstrated yet. We aimed to prospectively evaluate the effects of laparoscopic sleeve gastrectomy (LSG) on the structure and function of the esophagogastric junction (EGJ) and stomach. METHODS: Investigations were performed before and after > 50% reduction in excess body weight (6-12 months after LSG)...
March 23, 2020: Obesity Surgery
Ziqi Xu, Mingyao Li, Jinhao Lyu, Zhikai Hou, Jianfeng He, Dapeng Mo, Feng Gao, Xin Liu, Binbin Sui, Mi Shen, Yuesong Pan, Yongjun Wang, Xin Lou, Zhongrong Miao, Benyan Luo, Ning Ma
Background: We constructed a high-volume registry to identify whether risk factors of intracranial atherosclerotic plaque (ICAP) features differ in the posterior and anterior circulation in patients with symptomatic intracranial atherosclerotic stenosis (ICAS) investigated by high-resolution magnetic resonance imaging (HRMRI). Methods: The registry was constructed for patients with symptomatic ICAS who underwent HRMRI for culprit plaques. ICAP-vulnerable features included positive remodelling, diffuse distribution, intraplaque haemorrhage and strong enhancement...
2020: Therapeutic Advances in Neurological Disorders
Veronica Bordonaro, Anna Rita Larici, Paola Franchi, Fabiano Paciolla, Francesca Giubbolini, Agostino Meduri, Riccardo Marano, Riccardo Manfredi, Luigi Natale
Systemic immune-mediated diseases (SID) are a large group of disorders characterized by complex inflammatory and autoimmune damage to various organs and tissues. Among the possible manifestations, SIDs may potentially involve each structure of the cardiopulmonary system. Each disease is characterized by a specific clinical presentation. Coronary artery disease, myocarditis, pericarditis, valvular disease, pulmonary arterial hypertension, and interstitial lung disease represent characteristic findings of cardiopulmonary involvement in these disorders and their prompt recognition is crucial for the diagnosis of SIDs and the patient's prognosis...
March 20, 2020: Journal of Thoracic Imaging
Patrice Sudres, Morgane Evin, Pierre-Jean Arnoux, Virginie Callot
STUDY DESIGN: Continuous measurements and computation of absolute metrics of cervical subarachnoid space (CSS) and spinal cord (SC) geometries proposed are based on in vivo magnetic resonance imaging and 3D reconstruction. OBJECTIVE: The aim of the study is to offer a new methodology to continuously characterize and to quantify the detailed morphology of the CSS and the cervical SC in 3D for healthy subjects in both neutral supine and flexion. SUMMARY OF BACKGROUND DATA: To the best of our knowledge, no study provide a morphological quantification by absolute indices based on the 3D reconstruction of SC and CSS thanks to in vivo magnetic resonance imaging...
March 19, 2020: Spine
Yingjie Zheng, Bowen Zhen, Aichi Chen, Fulang Qi, Xiaohan Hao, Bensheng Qiu
PURPOSE: Spatial resolution is an important parameter for magnetic resonance imaging (MRI). High-resolution MR images provide detailed information and benefit subsequent image analysis. However, higher resolution MR images come at the expense of longer scanning time and lower signal-to-noise ratios (SNR). Using algorithms to improve image resolution can mitigate these limitations. Recently, some convolutional neural network (CNN)-based super-resolution (SR) algorithms have ourished on MR image reconstruction...
March 23, 2020: Medical Physics
Amy L Proskovec, Rachel K Spooner, Alex I Wiesman, Tony W Wilson
Two largely distinct bodies of research have demonstrated age-related alterations and disease-specific aberrations in both local gamma oscillations and patterns of cortical thickness. However, seldom has the relationship between gamma activity and cortical thickness been investigated. Herein, we combine the spatiotemporal precision of magnetoencephalography (MEG) with high-resolution magnetic resonance imaging and surface-based morphometry to characterize the relationships between somatosensory gamma oscillations and the thickness of the cortical tissue generating the oscillations in 94 healthy adults (age range: 22-72)...
March 18, 2020: NeuroImage
Giamaica Conti, Nicola Zingaretti, Domenico Amuso, Elena Dai Prè, Jessica Brandi, Daniela Cecconi, Marcello Manfredi, Emilio Marengo, Federico Boschi, Michele Riccio, Roberto Amore, Eugenio Luigi Iorio, Alice Busato, Francesco De Francesco, Valentina Riccio, Pier Camillo Parodi, Luca Vaienti, Andrea Sbarbati
: Background: Cellulite is a condition in which the skin has a dimpled lumpy appearance. The main causes of cellulite development, studied until now, comprehends modified sensitivity to estrogens, the damage of microvasculature present among dermis and hypodermis. The differences of adipose tissue architecture between male and female might make female more susceptible to cellulite. Adipose tissue is seen to be deeply modified during cellulite development. Our study tried to understand the overall features within and surrounding cellulite to apply the best therapeutic approach...
March 18, 2020: International Journal of Molecular Sciences
Lluís Guasch, Oscar Calderón Agudo, Meng-Xing Tang, Parashkev Nachev, Michael Warner
Magnetic resonance imaging and X-ray computed tomography provide the two principal methods available for imaging the brain at high spatial resolution, but these methods are not easily portable and cannot be applied safely to all patients. Ultrasound imaging is portable and universally safe, but existing modalities cannot image usefully inside the adult human skull. We use in silico simulations to demonstrate that full-waveform inversion, a computational technique originally developed in geophysics, is able to generate accurate three-dimensional images of the brain with sub-millimetre resolution...
2020: NPJ Digital Medicine
MungSoo Kang, SeokHa Jin, DongKyu Lee, HyungJoon Cho
Using superparamagnetic iron oxide nanoparticles (SPION) as a single contrast agent, we investigated dual contrast cerebrovascular magnetic resonance imaging (MRI) for simultaneously monitoring macro- and microvasculature and their association with ischemic edema status (via apparent diffusion coefficient [ADC]) in transient middle cerebral artery occlusion (tMCAO) rat models. High-resolution T1 -contrast based ultra-short echo time MR angiography (UTE-MRA) visualized size remodeling of pial arteries and veins whose mutual association with cortical ischemic edema status is rarely reported...
March 19, 2020: Scientific Reports
Recep A Ozdemir, Ehsan Tadayon, Pierre Boucher, Davide Momi, Kelly A Karakhanyan, Michael D Fox, Mark A Halko, Alvaro Pascual-Leone, Mouhsin M Shafi, Emiliano Santarnecchi
Large-scale brain networks are often described using resting-state functional magnetic resonance imaging (fMRI). However, the blood oxygenation level-dependent (BOLD) signal provides an indirect measure of neuronal firing and reflects slow-evolving hemodynamic activity that fails to capture the faster timescale of normal physiological function. Here we used fMRI-guided transcranial magnetic stimulation (TMS) and simultaneous electroencephalography (EEG) to characterize individual brain dynamics within discrete brain networks at high temporal resolution...
March 19, 2020: Proceedings of the National Academy of Sciences of the United States of America
Wendy Harris, Fang-Fang Yin, Jing Cai, Lei Ren
Background: The purpose of this study is to improve on-board volumetric cine magnetic resonance imaging (VC-MRI) using multi-slice undersampled cine images reconstructed using spatio-temporal k-space data, patient prior 4D-MRI, motion modeling (MM) and free-form deformation (FD) for real-time 3D target verification of liver and lung radiotherapy. Methods: A previous method was developed to generate on-board VC-MRI by deforming prior MRI images based on a MM and a single-slice on-board 2D-cine image...
February 2020: Quantitative Imaging in Medicine and Surgery
Erin K Englund, Michael C Langham
The endothelium regulates and mediates vascular homeostasis, allowing for dynamic changes of blood flow in response to mechanical and chemical stimuli. Endothelial dysfunction underlies many diseases and is purported to be the earliest pathologic change in the progression of atherosclerotic disease. Peripheral vascular function can be interrogated by measuring the response kinetics following induced ischemia or exercise. In the presence of endothelial dysfunction, there is a blunting and delay of the hyperemic response, which can be measured non-invasively using a variety of quantitative magnetic resonance imaging (MRI) methods...
2020: Frontiers in Physiology
Joseph L Sanguinetti, Stuart Hameroff, Ezra E Smith, Tomokazu Sato, Chris M W Daft, William J Tyler, John J B Allen
Transcranial focused ultrasound (tFUS) is an emerging method for non-invasive neuromodulation akin to transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). tFUS offers several advantages over electromagnetic methods including high spatial resolution and the ability to reach deep brain targets. Here we describe two experiments assessing whether tFUS could modulate mood in healthy human volunteers by targeting the right inferior frontal gyrus (rIFG), an area implicated in mood and emotional regulation...
2020: Frontiers in Human Neuroscience
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