Pierre Gressens, Michael Spedding, Gabor Gigler, Szabolcs Kertesz, Pascal Villa, Fadia Medja, Toni Williamson, Gabor Kapus, Gyorgy Levay, Gabor Szenasi, Jozsef Barkoczy, Laszlo G Harsing
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists have been shown to have neuroprotective effects in stroke models and although clinical trials with some agents are still ongoing, published results have not been favourable. We therefore wished to compare the effects of GYKI 52466, GYKI 53405, EGIS-8332 and EGIS-10608, non-competitive AMPA receptor antagonists with homophthalazine chemical structures, in standard animal stroke models with effects in a neurodegenerative model--excitoxicity in newborn mice...
September 5, 2005: European Journal of Pharmacology