Toby M Maher, Paul Ford, Kevin K Brown, Ulrich Costabel, Vincent Cottin, Sonye K Danoff, Irene Groenveld, Eric Helmer, R Gisli Jenkins, Julie Milner, Geert Molenberghs, Bjorn Penninckx, Matthew J Randall, Bernt Van Den Blink, Ann Fieuw, Charlotte Vandenrijn, Sanda Rocak, Ineke Seghers, Lixin Shao, Amit Taneja, Garrit Jentsch, Timothy R Watkins, Wim A Wuyts, Michael Kreuter, Nadia Verbruggen, Niyati Prasad, Marlies S Wijsenbeek
IMPORTANCE: There is a major need for effective, well-tolerated treatments for idiopathic pulmonary fibrosis (IPF). OBJECTIVE: To assess the efficacy and safety of the autotaxin inhibitor ziritaxestat in patients with IPF. DESIGN, SETTING, AND PARTICIPANTS: The 2 identically designed, phase 3, randomized clinical trials, ISABELA 1 and ISABELA 2, were conducted in Africa, Asia-Pacific region, Europe, Latin America, the Middle East, and North America (26 countries)...
May 9, 2023: JAMA