Dongzi Lin, Qiankun Liu, Wei Wang, Yanyun Li, Yumei Li, Bihua Lin, Ziyu Ye, Juan Huang, Xiaolin Yu, Yinwen Chen, Yuezhi Mei, Minyuan Huang, Weiqin Yang, Jie Zhou, Xinguang Liu, Jincheng Zeng
Tuberculosis (TB) immunity is affected by complex immune regulation processes, which involve various immune cells, immune molecules, and cytokines. Here, we evaluated the expression of B12, CD272 and miR-16 in peripheral blood mononuclear cells (PBMC) of patients with active pulmonary tuberculosis. The results showed that monocytes expressing CD272 or B12 were down-regulated in patients with tuberculosis. The expression of B12 and CD272 in T cells and monocytes is related to tuberculosis. In TB patients, the up-regulation of miR-16 was negatively correlated with B12 mRNA expression, miR-16 was mainly expressed in CD14+ monocytes, and CD272 mRNA was mainly expressed in CD19+ B cells...
2020: American Journal of Translational Research