Yin Li, Yu-Yu Wei, Yang Cao, Xiao-Yang Lu, Yuan Yao, Lin Wang
BACKGROUND: Carotid occlusive disease is a type of progressive disease resulting in ischemic stroke. Extracranial-intracranial bypass surgery represents a valid therapeutic option when medical treatment does not make effects. The appearance of cerebral edema following bypass is common during acute stage. Additionally, there are many causes of mild cerebral edema, such as hemodynamic changes, venous congestion and others. However, severe edema involving large brain tissue, which presents as reversible aphasia and hemiplegia, remains to be elucidated...
September 5, 2020: BMC Neurology
Pyry N Sipilä, Joni V Lindbohm, Archana Singh-Manoux, Martin J Shipley, Tuomo Kiiskinen, Aki S Havulinna, Jussi Vahtera, Solja T Nyberg, Jaana Pentti, Mika Kivimäki
INTRODUCTION: Conventional risk factors targeted by prevention (e.g., low education, smoking, and obesity) are associated with a 1.2- to 2-fold increased risk of dementia. It is unclear whether having a physical disease is an equally important risk factor for dementia. METHODS: In this exploratory multicohort study of 283,414 community-dwelling participants, we examined 22 common hospital-treated physical diseases as risk factors for dementia. RESULTS: During a median follow-up of 19 years, a total of 3416 participants developed dementia...
September 4, 2020: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Sepideh Nazarian, Zohreh Abdolmaleki, Alireza Torfeh, Seyed Hamed Shirazi Beheshtiha
Systemic treatments for ischemic stroke as a disease with high disability and death have been yet unsuccessful. Combined treatments can potentially cause better results in treatment of patients with Stroke. In this study we assessed the neuroprotective effect of modafinil-coated gold nanoparticles (AuNPs) and mesenchymal stem cell (MSC) in ischemic stroke rats. Stem cells and AuNPs offer great promise for new medical treatments. 60 male Wistar rats were randomly divided into five groups (12 in each group): (1) the group that developed middle cerebral artery occlusion (MCAO or ischemia), (2) the normal group (control), (3) the MCAO group that received MSC (C + MCAO), (4) the MCAO group that received MSC and modafinil (CM + MCAO), and (5) the MCAO group that received MSC and modafinil-coated AuNPs (CMN + MCAO)...
September 4, 2020: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Hajime Ikenouchi, Manabu Inoue, Kaori Miwa, Kenichiro Yi, Dai Suzuki, Toru Iwasa, Kazunori Toyoda, Masatoshi Koga
•The case of infant ischemic stroke with remarkable DWI reversal.•A mismatch between core volume and visually DWI lesion predicts DWI reversal.•Chronic hypoxia and early recanalization may contribute to large DWI reversal.•Mismatch between DWI-ASPECTS and core volume may occur in infant brain.
September 2020: ENeurologicalSci
Benjamin Y Q Tan, Aloysius St Leow, Tsong-Hai Lee, Vamsi Krishna Gontu, Tommy Andersson, Staffan Holmin, Ho-Fai Wong, Chuan-Min Lin, Chih-Kuang Cheng, Ching-Hui Sia, Nicholas Ngiam, Zhi-Xuan Ng, Joshua Yeo, Bernard Chan, Hock-Luen Teoh, Raymond Seet, Prakash Paliwal, Gopinathan Anil, Cunli Yang, Volker Maus, Nuran Abdullayev, Anastasios Mpotsaris, Pervinder Bhogal, Ken Wong, Hegoda Levansri Dilrukshan Makalanda, Oliver Spooner, Sageet Amlani, Daniel Campbell, Robert Michael, Ulf Quäschling, Stefan Schob, Jens Maybaum, Vijay Kumar Sharma, Leonard Ll Yeo
BACKGROUND: Endovascular thrombectomy (ET) has transformed acute ischemic stroke (AIS) therapy in patients with large vessel occlusion (LVO). Left ventricular systolic dysfunction (LVSD) decreases global cerebral blood flow and predisposes to hypoperfusion. We evaluated the relationship between LVSD, as measured by LV ejection fraction (LVEF), and clinical outcomes in patients with anterior cerebral circulation LVO who underwent ET. METHODS: This multicenter retrospective cohort study examined anterior circulation LVO AIS patients from six international stroke centers...
September 3, 2020: Journal of Neurointerventional Surgery
Linfang Lan, Haipeng Liu, Vincent Ip, Yannie Soo, Jill Abrigo, Florence Fan, Sze Ho Ma, Karen Ma, Bonaventure Ip, Jia Liu, Yuhua Fan, Jinsheng Zeng, Vincent Mok, Lawrence Wong, David Liebeskind, Thomas Leung, Xinyi Leng
BACKGROUND AND PURPOSE: Understanding the mechanisms underlying progression/regression of symptomatic intracranial atherosclerotic stenosis (sICAS) will inform secondary prevention of the patients. Focal wall shear stress (WSS) may play an important role, which, however, had seldom been investigated. METHODS: Patients with acute ischemic stroke or transient ischemic attack (TIA) attributed to 50% to 99% intracranial atherosclerotic stenosis were recruited. All patients underwent cerebral computed tomography angiography at baseline, and a computational fluid dynamics model was built based on computed tomography angiography to simulate blood flow and quantify WSS in the vicinity of the sICAS lesion...
September 4, 2020: Stroke; a Journal of Cerebral Circulation
Jian-Cong Weng, Jie Wang, Hao Li, Yu-Ming Jiao, Wei-Lun Fu, Ran Huo, Zi-Han Yan, Hong-Yuan Xu, Jiong Zhan, Shuo Wang, Xin Du, Yong Cao, Ji-Zong Zhao
BACKGROUND AND PURPOSE: The role of aspirin in unruptured intracranial aneurysm (UIA) growth remains largely unknown. We aim to identify whether aspirin is associated with a lower rate of UIA growth in patients with UIA <7 mm. METHODS: This prospective cohort study consecutively enrolled patients with UIAs <7 mm with ischemic cerebrovascular disease between January 2016 and December 2019. Baseline and follow-up patient information, including the use of aspirin and blood pressure level, were recorded...
September 3, 2020: Stroke; a Journal of Cerebral Circulation
Yasir Abdul, Weiguo Li, Rebecca Ward, Mohammed Abdelsaid, Sherif Hafez, Guangkuo Dong, Sarah Jamil, Victoria Wolf, Maribeth H Johnson, Susan C Fagan, Adviye Ergul
It is a clinically well-established fact that patients with diabetes have very poor stroke outcomes. Yet, the underlying mechanisms remain largely unknown. Our previous studies showed that male diabetic animals show greater hemorrhagic transformation (HT), profound loss of cerebral vasculature in the recovery period, and poor sensorimotor and cognitive outcomes after ischemic stroke. This study aimed to determine the impact of iron chelation with deferoxamine (DFX) on (1) cerebral vascularization patterns and (2) functional outcomes after stroke in control and diabetic rats...
September 1, 2020: Translational Stroke Research
Radhika Akku, Thulasi Priya Jayaprakash, Olisaemeka D Ogbue, Parul Malhotra, Safeera Khan
The relationship between end-stage renal disease (ESRD) and cerebral stroke is graded and cumulative, having a significant impact on morbidity and mortality. Ischemic stroke is more prevalent than hemorrhagic stroke and both stroke types have modifiable and non-modifiable risk factors. The presence of risk factors such as hypertension, diabetes, and atrial fibrillation (AF) before stroke occurrence in dialysis patients has a significant impact on the outcomes such as a discharge to rehabilitation, in-hospital mortality with the worst prognosis when compared to the general population...
July 30, 2020: Curēus
Satoshi Takahashi, Kazunari Yoshida
Background: To the authors' knowledge, reopening of a superficial temporal artery to middle cerebral artery (STA-MCA) bypass graft occluded by a white thrombus during the procedure and was observed several months after the surgery is relatively rare. Case Description: The authors encountered a case of moyamoya disease in an Asian female in her third decade of life, in whom a bypass recipient vessel was occluded by a white thrombus during surgery and remained occluded on magnetic resonance angiography (MRA) performed up to 6 weeks after the procedure...
2020: Surgical Neurology International
Elham Seifali, Gholamreza Hassanzadeh, Marzieh Mahdavipour, Keywan Mortezaee, Ashraf Moini, Leila Satarian, Faezeh Shekari, Abdoreza Nazari, Shabnam Movassaghi, Mohammad Akbari
Background: Ischemic stroke, as a health problem caused by the reduced blood supply to the brain, can lead to the neuronal death. The number of reliable therapies for stroke is limited. Mesenchymal stem cells (MSCs) exhibit therapeutic achievement. A major limitation of MSC application in cell therapy is the short survival span. MSCs affect target tissues through the secretion of many paracrine agents including extracellular vesicles (EVs). This study aimed to investigate the effect of human umbilical cord perivascular cells (HUCPVCs)-derived EVs on apoptosis, functional recovery, and neuroprotection...
November 2020: Iranian Biomedical Journal
Xiangrong Zheng, Yunpeng Wang, Guocang Chen, Chuanyong Ma, Weiming Yan, Meizhu Chen
RATIONALE: Ischemic optic neuropathy (ION), due to diseases of the arteries supplying the optic nerve, is an ischemic damage of the optic nerve. This report highlights a case with monocular decreasing visual acuity caused by dissection of the internal carotid artery (ICA), which is a relatively rare cause for ION. PATIENT CONCERNS: A 44-year-old woman presented with a decreasing visual acuity and defected visual field in the right eye for 1 week. The best corrected visual acuity (BCVA) was 20/400 in the right eye, and 20/20 in the left eye...
August 14, 2020: Medicine (Baltimore)
Seung Hak Lee, Bong-Kwang Jung, Hyemi Song, Han Gil Seo, Jong-Yil Chai, Byung-Mo Oh
Toxoplasma gondii is an obligate intracellular protozoan parasite that can invade various organs in the host body, including the central nervous system. Chronic intracranial T. gondii is known to be associated with neuroprotection against neurodegenerative diseases through interaction with host brain cells in various ways. The present study investigated the neuroprotective effects of chronic T. gondii infection in mice with cerebral ischemia experimentally produced by middle cerebral artery occlusion (MCAO) surgery...
August 2020: Korean Journal of Parasitology
Alba Simats, Laura Ramiro, Teresa García-Berrocoso, Ferran Briansó, Ricardo Gonzalo, Luna Martín, Anna Sabé, Natalia Gill, Anna Penalba, Nuria Colome, Alex Sánchez, Francesc Canals, Alejandro Bustamante, Anna Rosell, Joan Montaner
Stroke remains a leading cause of death and disability worldwide. Despite continuous advances, the identification of key molecular signatures in the hyper-acute phase of ischemic stroke is still a primary interest for translational research on stroke diagnosis, prognosis, and treatment. Data integration from high-throughput -omics techniques has become crucial to unraveling key interactions among different molecular elements in complex biological contexts, such as ischemic stroke. Thus, we used advanced data integration methods for a multi-level joint analysis of transcriptomics and proteomics datasets obtained from mouse brains at 2 h after cerebral ischemia...
August 31, 2020: Molecular & Cellular Proteomics: MCP
Shihao He, Ran Duan, Ziqi Liu, Xun Ye, Li Yuan, Tian Li, Cunxin Tan, Junshi Shao, Shusen Qin, Rong Wang
BACKGROUND: Cognitive impairment in adult moyamoya disease (MMD) is thought to be the result of ischemic stroke; however, the presence and extent of cognitive decline in asymptomatic patients is unclear. METHODS: After classification using T2-weighted fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), a total of 19 MMD patients with a history of cerebral infarction, 21 asymptomatic MMD patients, and 20 healthy controls matched for age, sex, and years of education were prospectively included in this study...
August 31, 2020: BMC Neurology
Hongjin Wang, Xiaogang Xu, Yue Yin, Shiqi Yu, Huijing Ren, Qiang Xue, Xiaoyu Xu
BACKGROUND: The initial factor in the occurrence, development, and prognosis of cerebral ischemia is vascular dysfunction in the brain, and vascular remodeling of the brain is the key therapeutic target and strategy for ischemic tissue repair. Catalpol is the main active component of the radix of Rehmannia glutinosa Libosch, and it exhibits potential pleiotropic protective effects in many brain-related diseases, including stroke. PURPOSE: The present study was designed to investigate whether catalpol protects vascular structure and promotes angiogenesis in cerebral ischemic rats and to identify its possible mechanisms in vivo and in vitro...
August 28, 2020: Phytomedicine
Alpana Garg, Amin Marji, Sachin Goyal, Rana Ismail
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory pathogen with remarkable properties of multisystem involvement and numerous complications. The coronavirus disease of 2019 (COVID-19) presenting as stroke is becoming more common. Herein, we describe an unusual case of COVID-19 in a patient who initially presented with myalgia, fatigue, loss of taste and smell, and non-specific memory impairment. Two months after infection with SARS-CoV-2, the patient presented with acute onset of right-sided weakness, sensory loss, and worsening cognitive impairment...
August 25, 2020: Curēus
Nihar Jena, Ramzi Ibrahim, Deepthi Tirunagari, Kirit Patel
A straddling thrombus within a patent foramen ovale (PFO), also known as an impending paradoxical embolism, is an infrequent event that is rarely encountered in clinical practice. This should be considered whenever there is an arterial embolism in the presence of right-sided thromboembolic disease. Symptoms are widely variable depending on the severity of thrombus and obstructive embolic events. We present a patient who arrived at the hospital with signs and symptoms consistent with a cerebrovascular disease that was ultimately diagnosed with small foci of acute ischemic cerebral infarcts, bilateral pulmonary emboli, and a straddling thrombus traversing three cardiac chambers...
July 27, 2020: Curēus
Chengbo Tan, Zifeng Wang, Miao Zheng, Songji Zhao, Hideo Shichinohe, Kiyohiro Houkin
BACKGROUND: Stroke is a leading cause of death and disability worldwide. Recently, brain secondary damage has been hypothesized to be a key aggravating element in an ischemic cascade. However, the interaction between cerebral infarction and immune organs has yet to be fully understood. In this study, we investigated the changes in the rat brain, spleen, thymus, mesenteric lymph node, and liver at 3, 7, and 13 days after transient middle cerebral artery occlusion (tMCAO) by immunohistochemistry...
August 31, 2020: Journal of Nippon Medical School
Tomohisa Nezu, Naohisa Hosomi
Carotid ultrasonography is useful for the assessments of the risk stratification for stroke or coronary artery disease, because it is a simple, repeatable, and noninvasive procedure. The carotid intima-media thickness (IMT), which is assessed using carotid ultrasonography, is a widely used surrogate marker for the severity of atherosclerosis. Several large clinical studies showed that increased carotid IMT is associated with the future stroke or cardiovascular events. In addition, in many clinical trials, it has been adopted for surrogate markers of clinical endpoints of medical intervention...
August 29, 2020: Journal of Atherosclerosis and Thrombosis
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"