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JOURNAL ARTICLE
Yingying Yue, Zong Chen, Xinhang Dong, Guodong Song, Xiaolei Jin
OBJECTIVE: Suture mesenchymal stem cells (SuSCs), possessing self-renewal and multilineage differentiation abilities, play a crucial role in cranial bone growth. However, the impact of the disease-causing fibroblast growth factor receptor 2 (FGFR2) mutation on SuSCs in Crouzon syndrome has not been explored. This study aims to employ a lentivirus to overexpress Fgfr2 and investigate its role in the pathogenesis of Crouzon syndrome. METHODS: Starting with the prevalent FGFR2 mutation site in patients with Crouzon syndrome, a lentiviral vector carrying the Fgfr2...
May 1, 2024: Journal of Craniofacial Surgery
#2
JOURNAL ARTICLE
Lei Zhang, Dongyin Qin, Qian Liu, Guangzhi Hu, Xinhua Huang
Dried bamboo shoots (DBS) are a natural resource with inherent silica content, which can serve as sacrificial templates for the formation of mesoporous carbon but also promote the generation of silicon carbide (SiC). Building on this, we introduced mesoporous and graphitic carbon/SiC (SiC/BSC) as the CDI electrode for copper ion (Cu2+ ) removal. Mesoporous carbon electrodes facilitate faster ion transport, diffusion, and electron-transfer pathways. Furthermore, SiC accelerates electron transfer and promotes faradic redox reactions during the charge and discharge processes...
April 30, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
#3
JOURNAL ARTICLE
Anila M Menon, Nagamalli Naga Sidhartha, Ipsha Shruti, Ajay Suresh, Ravindra Meena, Amol G Dikundwar, Deepak Chopra
The formulation of drug with improved bioavailability is always challenging and indispensable in the field of pharmaceutics. The control of intermolecular interactions via crystal engineering approach and solid-state molecular recognition results in the formation of active drug molecules with modulated pharmacological benefits. Therefore, with the aim to improve the solubility and dissolution rate of the drug chlorpropamide ( CPA ), the mechanochemical liquid-assisted grinding (LAG) of the drug with several pharmaceutically accepted excipients was performed...
April 30, 2024: Molecular Pharmaceutics
#4
JOURNAL ARTICLE
Ting Zhao, Congbo Huang, Na Li, Yaqi Ge, Ling Wang, Yujin Tang, Yuejin Wang, Yan Li, Chaohong Zhang
Proanthocyanidins (PAs) are an important group of flavonoids that contribute to astringency, color, and flavor in grape (Vitis vinifera) and wines. They also play a crucial role in enhancing plant resistance to various stresses. However, the underlying regulatory mechanism governing PAs biosynthesis, particularly in relation to conferring resistance to powdery mildew, has not been extensively explored. This study focused on identifying a key player in PAs biosynthesis, namely the plant U-box (PUB) E3 ubiquitin ligase VvPUB26...
May 1, 2024: Plant Physiology
#5
JOURNAL ARTICLE
Xiangyu Zhao, Tianfu Li, Tao Guo, Xiaojian He, Xiaohong Ren, Manli Wang, Caifen Wang, Can Peng, Jiwen Zhang, Li Wu
The spread of upper respiratory tract (URT) infections harms people's health and causes social burdens. Developing targeted treatment strategies for URT infections that exhibit good biocompatibility, stability, and strong antimicrobial effects remains challenging. The dual antimicrobial and antiviral effects of iodine (I2 ) in combination with the cooling sensation of l-menthol in the respiratory tract can simultaneously alleviate URT inflammation symptoms. However, as both I2 and l-menthol are volatile, addressing stability issues is crucial...
April 30, 2024: ACS Applied Materials & Interfaces
#6
JOURNAL ARTICLE
Skyler Resendez, Steven H Brown, Hugo Sebastian Ruiz Ayala, Prahalad Rangan, Jonathan Nebeker, Diane Montella, Peter L Elkin
BACKGROUND: There have been over 772 million confirmed cases of COVID-19 worldwide. A significant portion of these infections will lead to long COVID (post-COVID-19 condition) and its attendant morbidities and costs. Numerous life-altering complications have already been associated with the development of long COVID, including chronic fatigue, brain fog, and dangerous heart rhythms. OBJECTIVE: We aim to derive an actionable long COVID case definition consisting of significantly increased signs, symptoms, and diagnoses to support pandemic-related clinical, public health, research, and policy initiatives...
April 30, 2024: JMIR Public Health and Surveillance
#7
JOURNAL ARTICLE
Teng Li, Jie Liu, Min Guo, Fan-Chun Bin, Qi Duan, Xian-Zi Dong, Feng Jin, Katsumasa Fujita, Mei-Ling Zheng
Hydrogels containing chondrocytes have exhibited excellent potential in regenerating hyaline cartilage. However, chondrocytes are vulnerable to dedifferentiation during in vitro culture, leading to fibrosis and mechanical degradation of newly formed cartilage. We propose to modulate cartilage formation via the developed chondrocyte pericellular matrix (PCM) -like scaffolds for the first time, in which the S, M and L-sized scaffolds were fabricated by femtosecond laser maskless optical projection lithography of bovine serum albumin-glyceryl methacrylate hydrogel...
April 30, 2024: Advanced Healthcare Materials
#8
JOURNAL ARTICLE
Casey D Foley, Chin Lee, Ali Abou Taka, Kendrew Au, Etienne Chollet, Matthew A Kubasik, Laura M McCaslin, Timothy S Zwier
We present a detailed study of the time-dependent photophysics and photochemistry of a known conformation of the two protonated pentapeptides Leu-enkephalin (Tyrosine-Glycine-Glycine-Phenylalanine-Leucine, YGGFL) and its chromophore-swapped analogue FGGYL, carried out under cryo-cooled conditions in the gas phase. Using ultraviolet-infrared (UV-IR) double resonance, we record excited state IR spectra as a function of time delay between UV and IR pulses. We identify unique Tyr OH stretch transitions due to the S1 state and the vibrationally excited triplet state(s) formed by intersystem crossing, T n (v)...
April 30, 2024: Journal of the American Chemical Society
#9
JOURNAL ARTICLE
Charlotte M N Allerton, Joel T Arcari, Lisa M Aschenbrenner, Melissa Avery, Bruce M Bechle, Mohammad Amin Behzadi, Britton Boras, Leanne M Buzon, Rhonda D Cardin, Natasha R Catlin, Anthony A Carlo, Karen J Coffman, Alyssa Dantonio, Li Di, Heather Eng, Kathleen A Farley, Rose Ann Ferre, Steven S Gernhardt, Scott A Gibson, Samantha E Greasley, Siennah R Greenfield, Brett L Hurst, Amit S Kalgutkar, Emi Kimito, Lorraine F Lanyon, Gabrielle H Lovett, Yajing Lian, Wei Liu, Luis A Martínez Alsina, Stephen Noell, R Scott Obach, Dafydd R Owen, Nandini C Patel, Devendra K Rai, Matthew R Reese, Hussin A Rothan, Sylvie Sakata, Matthew F Sammons, Jean G Sathish, Raman Sharma, Claire M Steppan, Jamison B Tuttle, Patrick R Verhoest, Liuqing Wei, Qingyi Yang, Irina Yurgelonis, Yuao Zhu
Despite the record-breaking discovery, development and approval of vaccines and antiviral therapeutics such as Paxlovid, coronavirus disease 2019 (COVID-19) remained the fourth leading cause of death in the world and third highest in the United States in 2022. Here, we report the discovery and characterization of PF-07817883, a second-generation, orally bioavailable, SARS-CoV-2 main protease inhibitor with improved metabolic stability versus nirmatrelvir, the antiviral component of the ritonavir-boosted therapy Paxlovid...
April 30, 2024: Journal of Medicinal Chemistry
#10
JOURNAL ARTICLE
Tobias Winge, Lukas Imberg, Ben Perry, An Matheeusen, Guy Caljon, Dmitrii Kalinin, Bernhard Wünsch
Three types of modifications of antileishmanial pyrazole lead compounds 7 and 8 were conducted to expand the relationships between structural features and antileishmanial/antitrypanosomal activity: (1) the pyrazole core was retained or replaced by a 1,2,4-triazole ring; (2) various aryl moieties including 2-fluorophenyl, pyridin-3-yl and pyrazin-2-yl rings were attached at 3-position of the core azole; (3) either arylmethylamino or ureido substituents were introduced at 5-position of the azole core. The synthesis followed established routes starting with esters 9 or 15 and anhydride 21...
April 30, 2024: ChemMedChem
#11
JOURNAL ARTICLE
Theresa Lohr, Nicolas Julian Scheuplein, Christopher Jenkins, Isobel Norville, Christine Erk, Maximilian Stapf, Lukas Kirchner, Mitali Sarkar-Tyson, Ulrike Holzgrabe
Due to increasing antibiotic resistance, the development of anti-infectives with new mechanisms of action is crucial. Virulence factors such as the "macrophage infectivity potentiator" (Mip) protein, which catalyzes the folding of proline-containing proteins by means of their cis-trans isomerase (PPIase) activity, have come into focus as a potential new target. Since the inhibition of Mip by small molecules has been shown to lead to reduced virulence and survival in vitro, especially of Gram-negative bacteria such as Burkholderia pseudomallei (Bp), Neisseria meningitidis (Nm), and Neisseria gonorrhoeae (Ng), or Coxiella burnetii (Cb), among many others, a library of Mip inhibitors was developed...
April 30, 2024: Archiv der Pharmazie
#12
JOURNAL ARTICLE
Shu-Xi Jing, Connor M McDermott, Parker L Flanders, Mariana Reis-Havlat, Shao-Nong Chen, Ana K Bedran-Russo, James B McAlpine, Elizabeth A Ambrose, Guido F Pauli
In nature, proanthocyanidins (PACs) with A-type linkages are relatively rare, likely due to biosynthetic constraints in the formation of additional ether bonds to be introduced into the more common B-type precursors. However, A-type linkages confer greater structural rigidity on PACs than do B-type linkages. Prior investigations into the structure-activity relationships (SAR) describing how plant-derived PACs with B- and complex AB-type linkages affect their capacity for dentin biomodification indicate that a higher ratio of double linkages leads to a greater interaction with dentin type I collagen...
April 30, 2024: Journal of Natural Products
#13
JOURNAL ARTICLE
Kyle N Baustert, Joel H Bombile, Md Tawabur Rahman, Augustine O Yusuf, Ruipeng Li, Aron J Huckaba, Chad Risko, Kenneth R Graham
In both chemical and electrochemical doping of organic semiconductors (OSCs), a counterion, either from the electrolyte or ionized dopant, balances the charge introduced to the OSC. Despite the large influence of this counterion on the OSC optical and electronic response, there remains substantial debate on how a fundamental parameter, ion size, impacts these properties. This work addresses this discrepancy by accounting for two doping regimes. In the low-doping regime the Coulomb binding energies between polarons on the π-conjugated polymers and the counterions are significant, and larger counterions lead to decreased Coulomb interactions, more delocalized polarons, and higher electrical conductivities...
April 30, 2024: Advanced Materials
#14
JOURNAL ARTICLE
Zhuo Chen, Pengjie Wan, Ji Chen, Huan He, Dan Deng
BACKGROUND: The presence of scalp nevi in children frequently causes apprehension, leading physicians and parents to consider unnecessary biopsies or excisions of scalp nevi in children. There are limited data on the dermoscopic characteristics of scalp nevi in Chinese children. OBJECTIVE: The aim of this study was to comprehensively analyze the clinical and dermoscopic features of scalp nevi in this specific population of Chinese pediatric patients, with a focus on a single pediatric dermatologic surgery practice...
April 30, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
#15
JOURNAL ARTICLE
Hanna Orlikowska-Rzeznik, Jan Versluis, Huib J Bakker, Lukasz Piatkowski
The nanoscopic layer of water that directly hydrates biological membranes plays a critical role in maintaining the cell structure, regulating biochemical processes, and managing intermolecular interactions at the membrane interface. Therefore, comprehending the membrane structure, including its hydration, is essential for understanding the chemistry of life. While cholesterol is a fundamental lipid molecule in mammalian cells, influencing both the structure and dynamics of cell membranes, its impact on the structure of interfacial water has remained unknown...
April 30, 2024: Journal of the American Chemical Society
#16
JOURNAL ARTICLE
Aihong Qi, Puxian Li, Changli Lv
OBJECTIVE: The current study aimed to analyze the postoperative intracranial infection in patients with senile cerebral tumors treated by craniotomy. METHODS: This retrospective study included 116 patients with senile cranial tumors admitted and treated in our Hospital from January 2019 to January 2021. The patients were assigned to an observation group and a conventional group, by different nursing interventions, with 58 patients in each. Patients in both groups were treated with craniotomy, in which patients in the conventional group were given routine nursing...
April 26, 2024: Alternative Therapies in Health and Medicine
#17
JOURNAL ARTICLE
Mei Jiang, Jing Xu
OBJECTIVE: The objective of this study was to investigate and analyze the effects of esketamine combined with comprehensive nursing intervention on postoperative pain, postpartum depression, and quality of life in women undergoing cesarean section. METHODS: This study included 140 parturients who underwent cesarean section in The Second Hospital of Dalian Medical University (from May 2021 to May 2022). The participants were divided into two groups: the control group and the study group, based on random allocation...
April 26, 2024: Alternative Therapies in Health and Medicine
#18
JOURNAL ARTICLE
Yanbin Sun, Houling Zhao, Zhen Gao, Lei Li
OBJECTIVE: Deep venous thrombosis (DVT) refers to a clot in a deep vein caused by various reasons. If such a clot becomes dislodged, it can return to the vein and lead to pulmonary embolism (PE), which can cause death in severe cases. Therefore, we aimed to evaluate the efficacy and safety of Safflower yellow combined with low molecular weight heparin (LMWH) for the prevention of DVT after orthopedic surgery. METHODS: A comprehensive search of randomized controlled studies (RCTs) of Safflower yellow combined with LMWH for the prevention of DVT after orthopedic surgery was performed in PubMed, Embase, Cochrane Library, CNKI, VIP, and Wanfang databases from January 2000 to June 2021...
April 26, 2024: Alternative Therapies in Health and Medicine
#19
JOURNAL ARTICLE
Huifang Deng, Chunhua Li, Nuo Yu
OBJECTIVE: Iatrogenic skin injury is a common neonatal skin problem that can have a severe impact on the health and life of newborns. The purpose of this study was to explore the factors influencing iatrogenic skin injury in neonates, identify and correct nursing behaviors that may lead to skin damage, thereby reduce the occurrence of skin damage and protect the health of newborns. METHODS: The clinical data of 87 neonates with iatrogenic skin injury admitted to the Department of Neonatology of Shangrao People's Hospital, China, between January and June 2022, were retrospectively collected as a research group...
April 26, 2024: Alternative Therapies in Health and Medicine
#20
JOURNAL ARTICLE
Jing Liu, Hao Chen, Yan Lv, Huixiang Wu, Li-Jun Yang, Jiahui Zhang, Jianying Huang, Wenjie Wang
Aspergillus flavus contamination in agriculture and food industries poses threats to human health, leading to a requirement of a safe and effective method to control fungal contamination. Chitosan-based nitrogen-containing derivatives have attracted much attention due to their safety and enhanced antimicrobial applications. Herein, a new benzimidazole-grafted chitosan (BAC) was synthesized by linking the chitosan (CS) with a simple benzimidazole compound, 2-benzimidazolepropionic acid (BA). The characterization of BAC was confirmed by Fourier transform infrared (FTIR) spectroscopy and nuclear magnetic resonance spectroscopy (1 H and 13 C NMR)...
April 30, 2024: Journal of Agricultural and Food Chemistry
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