Daniela Fava, Andrea Calandrino, Maria Grazia Calevo, Anna Elsa Maria Allegri, Flavia Napoli, Roberto Gastaldi, Giuseppa Patti, Emilio Casalini, Marta Bassi, Andrea Accogli, Abdel Razaq Ahmad A Alyasin, Antonia Ramaglia, Andrea Rossi, Mohamad Maghnie, Giovanni Morana, Natascia Di Iorgi
CONTEXT: The etiology of central precocious puberty (CPP) includes a spectrum of conditions. Girls younger than age 6 years with CPP should undergo cranial magnetic resonance imaging (MRI), but it remains controversial whether all girls who develop CPP between the ages of 6 and 8 years require neuroimaging examination. OBJECTIVE: To investigate the frequency of brain MRI abnormalities in girls diagnosed with CPP and the relationship between maternal factors, their age at presentation, clinical signs and symptoms, hormonal profiles, and neuroimaging findings...
September 28, 2022: Journal of Clinical Endocrinology and Metabolism