Clara Savary, Léa Luciana, Paul Huchedé, Arthur Tourbez, Claire Coquet, Maëlle Broustal, Alejandro Lopez Gonzalez, Clémence Deligne, Thomas Diot, Olivier Naret, Mariana Costa, Nina Meynard, Virginie Barbet, Kevin Müller, Laurie Tonon, Nicolas Gadot, Cyril Degletagne, Valéry Attignon, Sophie Léon, Christophe Vanbelle, Alexandra Bomane, Isabelle Rochet, Virginie Mournetas, Luciana Oliveira, Paul Rinaudo, Christophe Bergeron, Aurélie Dutour, Martine Cordier-Bussat, Aline Roch, Nathalie Brandenberg, Sophie El Zein, Sarah Watson, Daniel Orbach, Olivier Delattre, Frédérique Dijoud, Nadège Corradini, Cécile Picard, Delphine Maucort-Boulch, Marion Le Grand, Eddy Pasquier, Jean-Yves Blay, Marie Castets, Laura Broutier
Rhabdomyosarcoma (RMS) is the main form of pediatric soft-tissue sarcoma. Its cure rate has not notably improved in the last 20 years following relapse, and the lack of reliable preclinical models has hampered the design of new therapies. This is particularly true for highly heterogeneous fusion-negative RMS (FNRMS). Although methods have been proposed to establish FNRMS organoids, their efficiency remains limited to date, both in terms of derivation rate and ability to accurately mimic the original tumor. Here, we present the development of a next-generation 3D organoid model derived from relapsed adult and pediatric FNRMS...
December 19, 2023: Cell reports medicine