Rodrigo B Mansur, Mehala Subramaniapillai, Yena Lee, Zihang Pan, Nicole E Carmona, Margarita Shekotikhina, Michelle Iacobucci, Nelson Rodrigues, Flora Nasri, Houman Rashidian, Joshua D Rosenblat, Elisa Brietzke, Victoria E Cosgrove, Nicole E Kramer, Trisha Suppes, Roger S McIntyre
A potential role for leptin in the pathophysiology of bipolar disorder (BD) has been proposed. We recently investigated the effects of the tumor necrosis factor-alpha (TNF-α) antagonist infliximab in individuals with bipolar depression. Leptin is known to interact with the TNF-α system. Herein, we aimed to explore infliximab's effects on leptin and its relationship with brain structure and function. Sixty adults with bipolar depression were enrolled in this randomized, double-blind, 12-week clinical trial of adjunctive infliximab (n = 29) and saline control (n = 31), which were administered intravenously at weeks 0, 2, and 6...
June 20, 2020: Psychoneuroendocrinology
Jan Kempski, Anastasios D Giannou, Kristoffer Riecken, Lilan Zhao, Babett Steglich, Jöran Lücke, Laura Garcia-Perez, Karl-Frederick Karstens, Anna Wöstemeier, Mikolaj Nawrocki, Penelope Pelczar, Mario Witkowski, Sven Nilsson, Leonie Konczalla, Ahmad Mustafa Shiri, Joanna Kempska, Ramez Wahib, Leonie Brockmann, Philipp Huber, Ann-Christin Gnirck, Jan-Eric Turner, Dimitra E Zazara, Petra C Arck, Alexander Stein, Ronald Simon, Anne Daubmann, Jan Meiners, Daniel Perez, Till Strowig, Pandelakis Koni, Andrey A Kruglov, Guido Sauter, Jakob R Izbicki, Andreas H Guse, Thomas Roesch, Ansgar W Lohse, Richard A Flavell, Nicola Gagliani, Samuel Huber
BACKGROUND & AIMS: Unregulated activity of interleukin 22 (IL22) promotes intestinal tumorigenesis in mice. IL22 binds the antagonist IL22 subunit alpha 2 (IL22RA2, also called IL22BP). We studied if alterations in IL22BP contribute to colorectal carcinogenesis in humans and mice. METHODS: We obtained tumor and non-tumor tissues from patients with colorectal cancer (CRC) and measured levels of cytokines by quantitative PCR, flow cytometry, and immunohistochemistry...
June 18, 2020: Gastroenterology
Sundas Hira, Uzma Saleem, Fareeha Anwar, Zohaib Raza, Atta Ur Rehman, Bashir Ahmad
Alzheimer's disease (AD) is the neurodegenerative disorder characterized by impairment of higher intellectual dysfunctions associated with changes in the cognitive, behavioral, and social activities. AIM OF THE STUDY: The current study was designed to evaluate the potential of aldosterone antagonist in the treatment of AD. METHODOLOGY: The study was conducted on albino mice of either sex ( n = 60). Mice were subcategorized into six groups, each group having 10 mice...
June 16, 2020: ACS Omega
Weifeng Jiang, Xiaoying Wang, Wei Wang, Fang Hua, Zunsheng Zhang, Zuohui Zhang, Jie Xiang, Xinxin Yang
Microglia, the resident immune cells in the central nervous system, play a critical role under physiological conditions, but they may be activated and exaggerate the pathological development of Parkinson's disease (PD). Recent reports have suggested that neurokinin 1 receptor (NK1R) is involved in various inflammatory diseases, including PD. However, whether neurokinin 1 (NK1) is involved in the activation of microglial cells remains unclear. In the present study, we found that (1) NK1R is located in microglial cells and upregulated in lipopolysaccharide (LPS)-activated BV2 microglia...
June 12, 2020: Brain Research Bulletin
Marliese Dion Nist, Rita H Pickler, Tondi M Harrison, Deborah K Steward, Abigail B Shoben
BACKGROUND: Preterm infants are at risk for impaired neurodevelopment. Inflammation may be an important modifiable mediator of preterm birth and neurodevelopmental impairment, but few studies have examined longitudinal measures of inflammation. OBJECTIVE: To determine the relationship between longitudinal measures of inflammation and neurobehavior in very preterm infants. STUDY DESIGN: Non-experimental, repeated measures cohort study. METHODS: Very preterm infants were enrolled between October 2017 and December 2018...
August 2020: Early Human Development
Xiao-Yan Luo, An-Wei Chen, Jin-Hua Cai, Jin Fang, Hua Wang
Chronic infantile neurological, cutaneous and articular (CINCA) syndrome is a rare autoinflammatory disease caused by monogenic defects in the NLRP3 gene. Pro-inflammatory cytokines such as interleukin (IL)-1β play a crucial role in the pathogenesis, and IL-1 receptor antagonists have been regarded as the mainstay therapy. Endogenous tumor necrosis factor (TNF)-α was found recently to be involved in the onset of the disease. Here, we report two Chinese children with CINCA syndrome who had elevated serum levels of TNF-α, with one carrying a novel mutation of c...
June 3, 2020: Journal of Dermatology
Mohamad Goldust, Jeffrey M Weinberg, Leon H Kircik, Sidharth Sonthalia, Vito Di Lernia, Dipali Rathod
BACKGROUND: Pityriasis lichenoides chronica, a papulosquamous disorder often considered a subtype of pityriasis lichenoides. It is considered a clonal T-cell disorder, which may be associated with cutaneous T-cell lymphoma that may develops in response to foreign antigens. CASE PRESENTATION: We present a 38-year-old male patient with ankylosing spondylitis who was on treatment with etanercept. After 8 weeks of treatment, the patient presented with scaly erythematous papules, on the back and arms...
May 1, 2020: Journal of Drugs in Dermatology: JDD
Danny D Dinh, Darcy Lidington, Jeffrey T Kroetsch, Chloe Ng, Hangjun Zhang, Sergei A Nedospasov, Scott P Heximer, Steffen-Sebastian Bolz
Subarachnoid hemorrhage (SAH) is a devastating cerebral event caused by an aneurysmal rupture. In addition to neurological injury, SAH has significant effects on cardiac function and the peripheral microcirculation. Since these peripheral complications may exacerbate brain injury, the prevention and management of these peripheral effects are important for improving the overall clinical outcome after SAH. In this investigation, we examined the effects of SAH on cardiac function and vascular reactivity in a well-characterized blood injection model of SAH...
2020: Frontiers in Physiology
James Ryan, Andrew I Bayliffe, Daniel F McAuley, Joyce Yeung, David R Thickett, Phillip A Howells, Ciara O'Donnell, Arlette M Vassallo, Tracey J Wright, Elizabeth McKie, Kelly Hardes, Charlotte Summers, Martin O Shields, William Powley, Robert Wilson, Aili L Lazaar, Andrew Fowler, Gavin D Perkins
BACKGROUND: Tumour necrosis factor receptor 1 (TNFR1) signalling mediates the cell death and inflammatory effects of TNF-α. OBJECTIVE: The current clinical trial investigated the effects of a nebulised TNFR1 antagonist (GSK2862277) on signs of lung injury in patients undergoing oesophagectomy. DESIGN: Randomised double-blind (sponsor unblind), placebo-controlled, parallel group study. SETTING: Eight secondary care centres, the United Kingdom between April 2015 and June 2017...
May 27, 2020: European Journal of Anaesthesiology
Sedigheh Amiresmaili, Mohammad Khaksari, Nader Shahrokhi, Moslem Abolhassani
Several studies have shown that 17β-estradiol (E2) exerted beneficial effects on liver disease, and it has a protective impact on brain damage after traumatic brain injury (TBI). TBI-induced liver injury is associated with the activation of TLR4. However, it remains unknown whether E2 can modulate TBI-induced liver injury through TLR4. The objective of this study was to determine the role of TLR4 in hepatoprotective mechanisms of E2 after TBI. Diffuse TBI induced by the Marmarou model in male rats. TAK-242 as a selective antagonist of TLR4 (3mg/kg) and E2 (33...
May 20, 2020: Biochemical Pharmacology
Mousumi Dutta, Prafulla Dutta, Subhash Medhi, Biswajyoti Borkakoty, Dipankar Biswas
Introduction: The pathogenicity of influenza virus infection is modulated by the cytokine expressions in patients. The present study was aimed to measure some important pro- and anti-inflammatory cytokines in influenza-infected population of Assam, Northeast India. Materials and Methods: Influenza viruses consisting of subtypes influenza A(H1N1)pdm09, H3N2 and influenza-B were detected in patients with symptoms of influenza-like-illness by Real-time reverse transcriptase polymerase chain reaction (RT-PCR) method...
October 2019: Indian Journal of Medical Microbiology
Cassandra M Townsend, Tran M Nguyen, Jeremy Cepek, Mohamad Abbass, Claire E Parker, John K MacDonald, Reena Khanna, Vipul Jairath, Brian G Feagan
BACKGROUND: Conventional medications for Crohn's disease (CD) include anti-inflammatory drugs, immunosuppressants and corticosteroids. If an individual does not respond, or loses response to first-line treatments, then biologic therapies such as tumour necrosis factor-alpha (TNF-α) antagonists such as adalimumab are considered for treating CD. Maintenance of remission of CD is a clinically important goal, as disease relapse can negatively affect quality of life. OBJECTIVES: To assess the efficacy and safety of adalimumab for maintenance of remission in people with quiescent CD...
May 16, 2020: Cochrane Database of Systematic Reviews
Carla Usai, Sheila Maestro, Gracian Camps, Cristina Olague, Lester Suárez-Amaran, Africa Vales, Tomas Aragon, Mirja Hommel, Rafael Aldabe, Gloria Gonzalez-Aseguinolaza
Background & Aims: HDV infection induces the most severe form of human viral hepatitis. However, the specific reasons for the severity of the disease remain unknown. Recently, we developed an HDV replication mouse model in which, for the first time, liver damage was detected. Methods: HDV and HBV replication-competent genomes and HDV antigens were delivered to mouse hepatocytes using adeno-associated vectors (AAVs). Aminotransferase elevation, liver histopathology, and hepatocyte death were evaluated and the immune infiltrate was characterized...
June 2020: JHEP reports: innovation in hepatology
Diana Brasselet, Laurent Chouchana, Thierry Vial, Marlène Damin-Pernik, Bénédicte Lebrun-Vignes
Objectives : The potential role of drugs in the onset of retroperitoneal fibrosis (RPF) is poorly understood. The aim of this study was to identify drugs that may cause RPF. Methods : The authors used the case/non-case method in the French PharmacoVigilance Database (FPVD). Results : Among the 722992 reports recorded, 73 cases of RPF were identified; 67% were men and the median age was 60 years (range 26-87). In these 73 cases, 176 drugs were 'suspect'. Derivatives of ergot alkaloids (DEA) presented the most significant association with RPF...
May 6, 2020: Expert Opinion on Drug Safety
Reza Rahimian, Mahsima Khoshneviszadeh, Taraneh Bahremand, Mohammad Reza Zirak, Ahmad Reza Dehpour, Kazem Mousavizadeh
Sildenafil is a phosphodiesterase type 5 inhibitor used to treat male erectile dysfunction and pulmonary hypertension. A potential side effect of sildenafil is a noticeable decrease in seizure threshold. Oxytocin (OXT) secretion and the subsequent cAMP-responsive element-binding (CREB) phosphorylation are involved in proconvulsant effects of sildenafil in experimental models. The aim of the present study was to investigate the potential role of OXT receptors and their downstream calcineurin (CN)/inducible nitric oxide synthase (iNOS) pathways in proconvulsant effects of sildenafil...
April 14, 2020: Hormones and Behavior
Eduardo da Silva Alves, Ronaldo Vagner Thomatiele Dos Santos, Fábio Santos de Lira, Alexandre Aparecido Almeida, Kate Edwards, Mateus Benvenutti, Sergio Tufik, Marco Túlio De Mello
Objective: To compare the effects of intensity-matched acute exercise at different intensities on proinflammatory and anti-inflammatory cytokines between able-bodied (AB) and spinal cord injured (SCI) individuals. Design: Non-Randomized Controlled Trial. Setting: Community settings in São Paulo - Brazil. Participants: Eight AB and nine SCI paraplegic. Interventions: Participants underwent three exercise sessions at different relative intensities: at ventilatory threshold 1 intensity (VT1), 15% below VT1, and 15% above VT1...
April 16, 2020: Journal of Spinal Cord Medicine
Tegan Triggs, Sailesh Kumar, Murray Mitchell
Introduction : Preterm birth is the leading cause of neonatal morbidity and mortality globally and poses a substantial economic burden. Consequently, there is a need for the identification of therapeutic targets and novel experimental drugs for the inhibition of preterm labour to improve neonatal outcomes. Areas covered : The authors review the pathophysiology of labour and the inflammatory pathways underpinning it. The interruption of these pathways forms the basis of therapeutic targets to inhibit preterm labour...
April 15, 2020: Expert Opinion on Investigational Drugs
Rodrigo B Mansur, Francheska Delgado-Peraza, Mehala Subramaniapillai, Yena Lee, Michelle Iacobucci, Nelson Rodrigues, Joshua D Rosenblat, Elisa Brietzke, Victoria E Cosgrove, Nicole E Kramer, Trisha Suppes, Charles L Raison, Sahil Chawla, Carlos Nogueras-Ortiz, Roger S McIntyre, Dimitrios Kapogiannis
Accumulating evidence suggests that neuroinflammation is involved in bipolar disorder (BD) pathogenesis. The tumor necrosis factor-alpha (TNF-α) antagonist infliximab was recently reported to improve depressive symptoms in a subpopulation of individuals with BD and history of childhood maltreatment. To explore the mechanistic mediators of infliximab's effects, we investigated its engagement with biomarkers of cellular response to inflammation derived from plasma extracellular vesicles enriched for neuronal origin (NEVs)...
April 6, 2020: Cells
Dong-Ya Huang, Qiang Li, Chen-Yuan Shi, Chao-Qun Hou, Yi Miao, Hong-Bing Shen
BACKGROUND: Excessive inflammatory responses play a critical role in the development of severe acute pancreatitis (SAP), and controlling such inflammation is vital for managing this often fatal disease. Dexmedetomidine has been reported to possess protective properties in inflammatory diseases. Therefore, this study aimed to investigate whether dexmedetomidine pre-treatment exerts an anti-inflammatory effect in rats with SAP induced by sodium taurocholate, and if so, to determine the potential mechanism...
April 6, 2020: Chinese Medical Journal
Wen-Chien Wang, Chih-Ying Kuan, Yu-Jing Tseng, Chia-Hsuan Chang, Yee-Chen Liu, Yu-Chih Chang, Yu-Chen Hsu, Ming-Kun Hsieh, Shan-Chia Ou, Wei-Li Hsu
Avian influenza virus (AIV) can cause severe diseases in poultry worldwide. H6N1 AIV was the dominant enzootic subtype in 1985 in the chicken farms of Taiwan until the initial outbreak of a low pathogenic avian influenza (LPAI) H5N2 virus in 2003; thereafter, this and other LPAIs have been sporadically detected. In 2015, the outbreak of three novel H5Nx viruses of highly pathogenic avian influenza (HPAI) emerged and devastated Taiwanese chicken and waterfowl industries. The mechanism of variation in pathogenicity among these viruses is unclear; but, in light of the many biological functions of viral non-structural protein 1 (NS1), including interferon (IFN) antagonist and host range determinant, we hypothesized that NS genetic diversity contributes to AIV pathogenesis...
2020: Frontiers in Microbiology
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