Tulip A Jhaveri, Disha Jhaveri, Amith Galivanche, Maya Lubeck-Schricker, Dominic Voehler, Mei Chung, Pruthu Thekkur, Vineet Chadha, Ruvandhi Nathavitharana, Ajay M V Kumar, Hemant Deepak Shewade, Katherine Powers, Kenneth H Mayer, Jessica E Haberer, Paul Bain, Madhukar Pai, Srinath Satyanarayana, Ramnath Subbaraman
BACKGROUND: India accounts for about one-quarter of people contracting tuberculosis (TB) disease annually and nearly one-third of TB deaths globally. Many Indians do not navigate all care cascade stages to receive TB treatment and achieve recurrence-free survival. Guided by a population/exposure/comparison/outcomes (PECO) framework, we report findings of a systematic review to identify factors contributing to unfavorable outcomes across each care cascade gap for TB disease in India. METHODS AND FINDINGS: We defined care cascade gaps as comprising people with confirmed or presumptive TB who did not: start the TB diagnostic workup (Gap 1), complete the workup (Gap 2), start treatment (Gap 3), achieve treatment success (Gap 4), or achieve TB recurrence-free survival (Gap 5)...
May 28, 2024: PLoS Medicine