Mohd Shiraz, Surabhi Lata, Pankaj Kumar, Umate Nachiket Shankar, Mohd Akif
Mycobacterium tuberculosis resides in alveolar macrophages as a non-dividing and dormant state causing latent tuberculosis. Currently, no vaccine available against the latent tuberculosis. Latent Mtb expresses ~48 genes under the control of DosR regulon. Among these, putative nitroreductases have significantly high expression levels, help Mtb to cope up with nitrogen stresses, and possess antigenic properties. In the current study, immunoinformatics methodologies are applied to predict the promiscuous antigenic T-cell epitopes from putative nitro-reductases, Rv2032, Rv3127, Rv3129, and Rv3131 of the DosR regulon...
July 28, 2021: Infection, Genetics and Evolution
Yan Lin, Haoxiang Lin, Lixin Xiao, Yongming Chen, Xu Meng, Xianglin Zeng, Chun Chang, Grania Brigden
OBJECTIVES: To determine tuberculosis (TB) recurrence in previously successfully treated patients in routine program setting and baseline characteristics associated with TB recurrence. METHODS: A prospective longitudinal study in Jiangxi Province, China. Patients, ≥14 years old, were consecutively registered and were followed-up for 7-year to assess TB recurrence against patients' individual baseline data that was entered into a database at TB registration. RESULTS: There were 800 TB patients registered at baseline and 634 (79...
July 28, 2021: International Journal of Infectious Diseases: IJID
Timothy Pw Jones, Susannah Dabbaj, Indrajeet Mandal, Joanne Cleverley, Charlotte Cash, Marc Ci Lipman, David M Lowe
BACKGROUND: Post-tuberculous lung disease confers significant morbidity. However, the determinants of persistent lung damage in tuberculosis are not well established. We investigated associations between tuberculosis-associated radiological changes and socio-demographic factors, surrogates of bacillary burden and blood inflammatory markers at initiation of therapy and after 1 month. RESEARCH QUESTION: What are the predictors of radiological severity at the end of tuberculosis treatment for tuberculosis? STUDY DESIGN AND METHODS: We collected data from patients treated for drug sensitive pulmonary tuberculosis at our centre over a 5...
July 28, 2021: Chest
Eamonn Gormley, Deirdre Ní Bhuachalla, Tara Fitzsimons, James O'Keeffe, Guy McGrath, Jamie M Madden, Naomi Fogarty, Kevin Kenny, Locksley L McV Messam, Denise Murphy, Leigh A L Corner
Vaccination of badgers with Mycobacterium bovis Bacille Calmette Guérin (BCG) has been shown to protect badgers against tuberculosis in experimental trials. During the three-year County Kilkenny BCG vaccine field study, badgers were treated orally with placebo (100% in Zone A), BCG (100% in Zone C) or randomly assigned 50%: 50% treatment with BCG or placebo (Zone B). At the end of the study 275 badgers were removed from the trial area and subjected to detailed post-mortem examination followed by histology and culture for M...
July 31, 2021: Transboundary and Emerging Diseases
Sarah Welby, Mickaël Cargnel, Claude Saegerman
INTRODUCTION: Despite eradication and control measures applied across Europe, bovine tuberculosis (bTB) remains a constant threat. In Belgium, after several years of official bTB-free status, routine movement testing, as currently practiced, revealed itself inadequate to detect some herds affected by sporadic breakdowns. The aim of this study was to assess different surveillance system components that strike a balance between cost and effectiveness and to identify sustainable alternatives, which substantiate a bTB-free claim whilst ensuring early detection too, as well as acceptance by various animal health stakeholders...
July 31, 2021: Transboundary and Emerging Diseases
Berecha Bayissa, Asegedech Sirak, Aboma Zewude, Adane Worku, Balako Gumi, Stefan Berg, R Glyn Hewinson, James L N Wood, Gareth J Jones, H Martin Vordermeier, Gobena Ameni
Bovine tuberculosis (bTB) challenges intensive dairy production in Ethiopia and implementation of the test and slaughter control strategy is not economically acceptable in the country. Vaccination of cattle with Bacillus Calmette-Guerin (BCG) could be an important adjunct to control, which would require a diagnostic test to differentiate Mycobacterium bovis (M. bovis)-infected and BCG-vaccinated animals (DIVA role). This study describes an evaluation of a DIVA skin test (DST) that is based on a cocktail (DSTc) or fusion (DSTf) of specific (ESAT-6, CFP-10, and Rv3615c) M...
July 31, 2021: Transboundary and Emerging Diseases
Alice Halliday, Tereza Masonou, Mica R Tolosa-Wright, Yanping Guo, Long Hoang, Robert Parker, Aime Boakye, Yemisi Takwoingi, Amarjit Badhan, Pooja Jain, Ishita Marwah, Luis C Berrocal-Almanza, Jonathan Deeks, Peter Beverley, Onn Min Kon, Ajit Lalvani
BACKGROUND: Diagnosis of paucibacillary tuberculosis (TB) including extrapulmonary TB is a significant challenge, particularly in high-income, low-incidence settings. Measurement of Mycobacterium tuberculosis (Mtb)-specific cellular immune signatures by flow cytometry discriminates active TB from latent TB infection (LTBI) in case-control studies; however, their diagnostic accuracy and clinical utility in routine clinical practice is unknown. METHODS: Using a nested case-control study design within a prospective multicenter cohort of patients presenting with suspected TB in England, we assessed diagnostic accuracy of signatures in 134 patients who tested interferon-gamma release assay (IGRA)-positive and had final diagnoses of TB or non-TB diseases with coincident LTBI...
July 31, 2021: Journal of Infectious Diseases
Sunil Dodani, Asma Nasim, Tahir Aziz, Anwar Naqvi
INTRODUCTION: Renal transplant recipients are at high risk of tuberculosis (TB). We started Isoniazid (INH) prophylaxis of 1 year duration in all renal transplant recipients from April 2009. Our aim was to assess the incidence of TB on INH prophylaxis and its tolerability. METHODS: This was a retrospective observational study. The files of renal transplant recipients from April 2009 to December 2011 were reviewed till June 2015. We noted the incidence of TB, INH tolerability and development of resistance...
July 31, 2021: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Georgi Prisadov, Holger Hendrix, Vladimir Kamlak, Katrin Welcker
Localized solitary fibrous tumors are a rare entity and are mostly found in the thorax, but can also occur in the liver, skin, meninges, peritoneum, and pericardium. Making the diagnosis is often difficult because of the various micromorphologic outlooks. The histopathological assessment with differentiated immunohistochemistry is decisive. Surgical resection of the localized solitary fibrous tumors is the therapy of choice. The recurrence and metastasis rates depend on the histological dignity and are in total very low...
July 30, 2021: Pneumologie
Rosa Stalteri Mastrangelo, Nancy Santesso, Antonio Bognanni, Andrea Darzi, Samer Karam, Thomas Piggott, Tejan Baldeh, Finn Schünemann, Matthew Ventresca, Gian Paolo Morgano, Lorenzo Moja, Mark Loeb, Holger Schunemann
OBJECTIVES: Guidelines that include antimicrobial recommendations should explicitly consider contextual factors that influence antimicrobial resistance and their downstream effects on resistance selection. The objectives were to analyse (1) how, and to what extent, tuberculosis, gonorrhoea and respiratory tract infection guidelines are considering antimicrobial resistance; (2) are of acceptable quality and (3) if they can be easily contextualised to fit the needs of specific populations and health systems...
July 30, 2021: BMJ Open
S Yang, J Falardeau, K L Winthrop, E Henkle
No abstract text is available yet for this article.
August 1, 2021: International Journal of Tuberculosis and Lung Disease
K J Kim, I-S Kim, S-H Oh, S M Lee, H-J Lee, S H Kang, J B Lee, Y L Ryu, C L Chang
No abstract text is available yet for this article.
August 1, 2021: International Journal of Tuberculosis and Lung Disease
I Annesi-Maesano, S Banerjee, N Pham-Thi
No abstract text is available yet for this article.
August 1, 2021: International Journal of Tuberculosis and Lung Disease
M Ralki, E De Langhe, A Wilmer, G Hermans, J Wauters, P Meersseman, R Vos, D E Van Raemdonck, L J Ceulemans, A P Neyrinck, M Peetermans
No abstract text is available yet for this article.
August 1, 2021: International Journal of Tuberculosis and Lung Disease
P Ranaivomanana, A M Knoblauch, M C Razafimahatratra, A H Raherinandrasana, S Grandjean Lapierre, P Herindrainy, R Ratovoson, J Rakotonirina, N Rakotosamimanana
No abstract text is available yet for this article.
August 1, 2021: International Journal of Tuberculosis and Lung Disease
J J Eddy, B Seth, L F White, C A Sulis, M A Fagan, J Bernardo
No abstract text is available yet for this article.
August 1, 2021: International Journal of Tuberculosis and Lung Disease
M C Clarkson, C F McQuaid, R M Houben, K Kranzer, R G White
No abstract text is available yet for this article.
August 1, 2021: International Journal of Tuberculosis and Lung Disease
A Perry, A Chitnis, A Chin, C Hoffmann, L Chang, M Robinson, G Maltas, E Munk, M Shah
BACKGROUND: Video directly observed therapy (vDOT) was introduced to increase flexibility and meet patient-specific needs for TB treatment. This study aimed to assess the reach and effectiveness of vDOT for TB treatment under routine conditions in Alameda County, CA, USA, a busy, urban setting, from 2018 to 2020. METHODS: We prospectively evaluated routinely collected data to estimate 1) reach (proportion of patients initiated on vDOT vs. in-person DOT); and 2) effectiveness (proportion of prescribed doses with verified administration by vDOT vs...
August 1, 2021: International Journal of Tuberculosis and Lung Disease
Q Chen, M Zhang, F Si, S Wang, X Xu, L Yu, K Lai, Z Qiu
BACKGROUND: Gabapentin and baclofen are recommended for the treatment of chronic refractory cough (CRC). We investigated the efficacy of flupentixol/melitracen in patients unresponsive to these neuromodulators. METHODS: A total of 101 patients with CRC who failed to respond to gabapentin and baclofen were recruited, and treated with flupentixol/melitracen. The prevalence of cough resolution and changes in the Cough Symptom Score (CSS), cough thresholds to capsaicin, Hull Airway Reflux Questionnaire (HARQ), Leicester Cough Questionnaire (LCQ), Generalized Anxiety Disorder-7, Hamilton Anxiety Rating Scale, Patient Health Questionnaire-9, and Hamilton Depression Rating Scale-24 were evaluated after treatment...
August 1, 2021: International Journal of Tuberculosis and Lung Disease
A Readhead, G Cooksey, J Flood, P Barry
BACKGROUND: Hospitalization is a costly event that affects more than half of all TB patients in the United States. State-level hospitalization data are crucial in estimating the cost of TB disease and the financial impact of preventing TB. METHODS: We used California administrative hospital discharge data from 2009 to 2017 to characterize TB hospitalizations in comparison with non-neonatal, non-maternal hospitalizations. TB hospitalization was defined as a hospitalization with a TB ICD-9/10 code as the primary diagnosis...
August 1, 2021: International Journal of Tuberculosis and Lung Disease
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