Priyanka, Sadhna Sharma, Mandira Varma-Basil, Monika Sharma
Mycobacterium tuberculosis (Mtb) genome possesses a unique family called Proline-Glutamate/Proline-Proline-Glutamate (PE/PPE) gene family, exclusive to pathogenic mycobacterium. Some of these proteins are known to play role in virulence and immune response modulation, but many are still uncharacterized. This study investigated the role of C-terminal region of Rv1039c (PPE15) in inducing mitochondrial perturbations and macrophage apoptosis. Our in-silico studies revealed the disordered, coiled, and hydrophobic C-terminal region in Rv1039c has similarity with C-terminal of mitochondria-targeting pro-apoptotic host proteins...
April 14, 2024: Apoptosis: An International Journal on Programmed Cell Death
Archana Buch, Khushi Jain, Hetal Rathod, Charusheela Gore
BACKGROUND: Tumour budding Tuberculosis is a new prognostic marker whose role in breast cancer is still under evaluation. Our aim was to study Tuberculosis in breast carcinoma and correlate it with other prognostic markers. METHODS: A descriptive cross-sectional study was conducted over 2 years on 75 invasive breast carcinoma specimens and biopsies. Hematoxylin and Eosin sections were examined for tumour grade, stage, molecular subtype, necrosis, lymphovascular invasion inflammation and counting of Tuberculosis...
March 22, 2024: Journal of Nepal Health Research Council
Chunli Liu, Xing Li
Tuberculosis (TB) poses significant challenges due to its high transmissibility within populations and intrinsic resistance to treatment, rendering it a formidable respiratory disease with a substantial susceptibility burden. This study was designed to identify new potential therapeutic targets for TB and establish a diagnostic model. mRNA expression data for TB were from GEO database, followed by conducting differential expression analysis. The top 50 genes with differential expression were subjected to GO and KEGG enrichment analyses...
April 13, 2024: AMB Express
Shan Kai Ing, Grace Wan Chieng Lee, Tze Shin Leong, Yih Hoong Lee, George Yew Liang Lau, Nur Nazihah Yusof, Andrew Kean Wei Chang, Kelly Kee Yung Wong
Tuberculosis-associated hemophagocytic lymphohistiocytosis (TB-HLH) is a rare and life-threatening complication of tuberculosis infection. Early recognition and treatment of TB-HLH is crucial for improving outcomes. Treatment typically involves a combination of antituberculosis therapy and immunosuppressive therapy to control the immune system's overreaction. In this report, we present the case of a 53-year-old ambulance driver who was diagnosed with TB-HLH. His CT scan revealed splenic abscesses, hepatomegaly and bilateral lung consolidation...
July 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
Li Chen, Wen Yuan, Mengjie Geng, Rongbin Xu, Yi Xing, Bo Wen, Yao Wu, Xiang Ren, Yue Shi, Yi Zhang, Xinli Song, Yang Qin, RuoLin Wang, Jianuo Jiang, Ziqi Dong, Jieyu Liu, Tongjun Guo, Zhiying Song, Liping Wang, Yinghua Ma, Yanhui Dong, Yi Song, Jun Ma
This study assesses the association of short-term exposure to PM2.5 (particles ≤2.5 μm) on infectious diseases among Chinese children and adolescents. Analyzing data from 507 cities (2008-2021) on 42 diseases, it focuses on PM2.5 components (black carbon (BC), ammonium (NH4 + ), inorganic nitrate (NO3 - ), organic matter (OM), and sulfate (SO4 2- )). PM2.5 constituents significantly associated with incidence. Sulfate showed the most substantial effect, increasing all-cause infectious disease risk by 2...
April 11, 2024: Science of the Total Environment
Daniela Pinto, Gonçalo Themudo, André C Pereira, Ana Botelho, Mónica V Cunha
Epidemiological surveillance of animal tuberculosis (TB) based on whole genome sequencing (WGS) of Mycobacterium bovis has recently gained track due to its high resolution to identify infection sources, characterize the pathogen population structure, and facilitate contact tracing. However, the workflow from bacterial isolation to sequence data analysis has several technical challenges that may severely impact the power to understand the epidemiological scenario and inform outbreak response. While trying to use archived DNA from cultured samples obtained during routine official surveillance of animal TB in Portugal, we struggled against three major challenges: the low amount of M...
March 30, 2024: International Journal of Molecular Sciences
Xiaofei Qiu, Qianqian Zhang, Zhaoguo Li, Juan Zhang, Huanxiang Liu
With the rapid emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb), various levels of resistance against existing anti-tuberculosis (TB) drugs have developed. Consequently, the identification of new anti-TB targets and drugs is critically urgent. DNA gyrase subunit B (GyrB) has been identified as a potential anti-TB target, with novobiocin and SPR719 proposed as inhibitors targeting GyrB. Therefore, elucidating the molecular interactions between GyrB and its inhibitors is crucial for the discovery and design of efficient GyrB inhibitors for combating multidrug-resistant TB...
March 28, 2024: International Journal of Molecular Sciences
Leydi M Moreno, Jairo Quiroga, Rodrigo Abonia, María Del P Crespo, Carlos Aranaga, Luis Martínez-Martínez, Maximiliano Sortino, Mauricio Barreto, María E Burbano, Braulio Insuasty
This study presents the synthesis of four series of novel hybrid chalcones ( 20,21 ) a - g and ( 23,24 ) a - g and six series of 1,3,5-triazine-based pyrimido[4,5- b ][1,4]diazepines ( 28 - 33 ) a - g and the evaluation of their anticancer, antibacterial, antifungal, and cytotoxic properties. Chalcones 20b , d , 21a,b , d , 23a , d - g , 24a - g and the pyrimido[4,5- b ][1,4]diazepines 29e , g , 30g , 31a , b , e - g , 33a , b , e - g exhibited outstanding anticancer activity against a panel of 60 cancer cell lines with GI50 values between 0...
March 23, 2024: International Journal of Molecular Sciences
Kathleen Möller, Axel Löwe, Christian Jenssen, Nitin Chaubal, Heike Gottschall, Benjamin Misselwitz, Meghana Reddy Kurapati, Anoop Reddy Puritipati, Yi Dong, Siegbert Faiss, Christoph F Dietrich
This review describes the appearance of extrapulmonary tuberculosis manifestations in comprehensive and multiparametric ultrasound imaging. The aim is to increase awareness of typical ultrasound findings regarding extrapulmonary tuberculosis, correlate those with pathological features, and facilitate differential diagnosis. Point of care ultrasound protocols can be used as a screening method in high-risk populations, although the negative findings do not exclude tuberculosis. Conversely, the diagnosis of extrapulmonary tuberculosis can never be made using ultrasound alone, as many ultrasound findings in extrapulmonary tuberculosis are non-specific...
March 27, 2024: Diagnostics
Anna Starshinova, Nikolay Osipov, Irina Dovgalyk, Anastasia Kulpina, Ekaterina Belyaeva, Dmitry Kudlay
The COVID-19 pandemic resulted in the cessation of many tuberculosis (TB) support programs and reduced screening coverage for TB worldwide. We propose a model that demonstrates, among other things, how undetected cases of TB affect the number of future M. tuberculosis ( M. tb ) infections. The analysis of official statistics on the incidence of TB, preventive examination coverage of the population, and the number of patients with bacterial excretion of M. tb in the Russian Federation from 2008 to 2021 is carried out...
March 26, 2024: Diagnostics
Yijiao Xu, Qingwei Zhang, Zhisheng Chen, Shuwen Yang, Haiyan Chen, Xiong Xiao, Hongni Jiang
BACKGROUND: Tuberculosis (TB), a highly contagious respiratory disease, presents a significant global health threat, with a notable increase in incidence reported by the WHO in 2022. Particularly, the interplay between TB and non-small cell lung cancer (NSCLC) gains attention, especially considering the rising use of immune checkpoint inhibitors (ICIs) in cancer treatment. This interplay may influence TB diagnostics and reactivation, warranting a closer examination. METHODS: A retrospective analysis was conducted on clinical data of NSCLC patients with positive T-SPOT results before undergoing anti-tumor treatment at Zhongshan Hospital (Xiamen), Fudan University, from January 1, 2021 to December 31, 2022...
April 12, 2024: BMC Pulmonary Medicine
Jacob Nignan Nabei, Harriet Affran Bonful, Edwin Andrews Afari, Abdul Gafaru Mohammed, Adote Anum
BACKGROUND: Tuberculosis (TB) and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) co-morbidity continues to be a serious worldwide health issue, particularly in Sub-Saharan Africa. Studies on the quality of life (QOL) of TB/HIV co-infected patients guide stakeholders on the delivery of patient-centred healthcare. This study evaluated QOL of TB/HIV co-infected individuals and its contributing factors. METHODS: We conducted a cross-sectional study among TB/HIV co-infected patients, receiving treatment at clinics in the Northern Region of Ghana...
April 12, 2024: BMC Infectious Diseases
G Deslée, O Le Rouzic, M Zysman, N Roche
No abstract text is available yet for this article.
April 11, 2024: Revue des Maladies Respiratoires
J Ancel, E Chen, A Pavot, L Regard, O Le Rouzic, M Guecamburu, M Zysman, A Rapin, C Martin, T Soumagne, M Patout, N Roche, G Deslee
INTRODUCTION: The second COPD Biennial organized by the COPD working group of the French Society of Respiratory Diseases took place in Paris (Cochin) on 13th December 2023. STATE OF THE ART: Major trends in 2023 were discussed; they encompassed concepts, definitions, biologics, care pathways, pulmonary rehabilitation and complex situations entailed by respiratory infections, cardiovascular comorbidities and pulmonary hypertension, and modalities of oxygen therapy and ventilation...
April 11, 2024: Revue des Maladies Respiratoires
J Mayaux, M Decavele, M Dres, M Lecronier, A Demoule
Acute respiratory failure (ARF) is a leading cause, along with sepsis, of admission to the intensive care unit (ICU) of patients with active cancer. Presenting variable clinical severity, ARF in onco-hematological patients has differing etiologies, primarily represented by possibly opportunistic acute infectious pneumonia (de novo hypoxemic ARF), and decompensation in chronic cardiac or respiratory diseases (e.g., acute pulmonary edema or exacerbated chronic obstructive pulmonary disease). In these patients, orotracheal intubation is associated with a doubled risk of in-hospital mortality...
April 11, 2024: Revue des Maladies Respiratoires
Yun-Kyoung Song, Jaehee Lee, Junwoo Jo, Jin-Won Kwon
OBJECTIVES: This study aimed to evaluate the risk of tuberculosis associated with the use of Janus kinase (JAK) inhibitors or biological disease-modifying antirheumatic drugs (bDMARDs) in patients diagnosed with rheumatoid arthritis (RA) in South Korea. METHODS: In this nationwide matched-cohort study, we retrospectively identified adult patients with new-onset RA from the National Health Insurance Service database who were prescribed bDMARDs or JAK inhibitors and recently underwent latent tuberculosis infection (LTBI) screening during 2012‒2021, and followed them up until the end of 2022 for the development of active tuberculosis...
April 12, 2024: RMD Open
Ikhwanuliman Putera, Josianne C E M Ten Berge, Alberta A H J Thiadens, Willem A Dik, Rupesh Agrawal, P Martin van Hagen, Rina La Distia Nora, Saskia M Rombach
AIMS: To assess the risk of uveitis relapse in ocular tuberculosis (OTB) following clinical inactivity, to analyse clinical factors associated with relapses and to describe the management strategies for relapses. METHODS: A retrospective study was conducted on a 10-year patient registry of patients with OTB diagnosed at Erasmus MC in Rotterdam, The Netherlands. Time-to-relapse of uveitis was evaluated with Kaplan-Meier curve and risk factors for relapses were analysed...
April 12, 2024: British Journal of Ophthalmology
Yingda L Xie, Christie Eichberg, Nchimunya Hapeela, Elizabeth Nakabugo, Irene Anyango, Kiranjot Arora, Jeffrey E Korte, Ronald Odero, Judi van Heerden, Widaad Zemanay, Samuel Kennedy, Pamela Nabeta, Mahmud Hanif, Camilla Rodrigues, Alena Skrahina, Wendy Stevens, Reynaldo Dietze, Xin Liu, Jerrold J Ellner, David Alland, Moses L Joloba, Samuel G Schumacher, Kimberly D McCarthy, Lydia Nakiyingi, Susan E Dorman
BACKGROUND: Xpert MTB/RIF Ultra (Ultra) is an automated molecular test for the detection of Mycobacterium tuberculosis in sputum. We compared the sensitivity of Ultra to that of mycobacterial growth indicator tube (MGIT) liquid culture, considered the most sensitive assay in routine clinical use. METHODS: In this prospective, multicentre, cross-sectional diagnostic accuracy study, we used a non-inferiority design to assess whether the sensitivity of a single Ultra test was non-inferior to that of a single liquid culture for detection of M tuberculosis in sputum...
April 9, 2024: The Lancet. Microbe
Tony Kirby
No abstract text is available yet for this article.
April 9, 2024: Lancet Respiratory Medicine
Nikolaj Frost, Claas Wesseler, Bernhard Wörmann, Wilfried Ernst Erich Eberhardt
No abstract text is available yet for this article.
April 2024: Pneumologie
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