Stephanie S Cabler, Gregory A Storch, Jason B Weinberg, Andrew H Walton, Karen Brengel-Pesce, Zachary Aldewereld, Russell K Banks, Valerie Cheynet, Ron Reeder, Richard Holubkov, Robert A Berg, David Wessel, Murray M Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C Lin, Tim Cornell, Rick E Harrison, J Michael Dean, Joseph A Carcillo
IMPORTANCE: Sepsis is a leading cause of pediatric mortality. Little attention has been paid to the association between viral DNA and mortality in children and adolescents with sepsis. OBJECTIVE: To assess the association of the presence of viral DNA with sepsis-related mortality in a large multicenter study. DESIGN, SETTING, AND PARTICIPANTS: This cohort study compares pediatric patients with and without plasma cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus 1 (HSV-1), human herpesvirus 6 (HHV-6), parvovirus B19 (B19V), BK polyomavirus (BKPyV), human adenovirus (HAdV), and torque teno virus (TTV) DNAemia detected by quantitative real-time polymerase chain reaction or plasma IgG antibodies to CMV, EBV, HSV-1, or HHV-6...
February 5, 2024: JAMA Network Open