Ediandra T Castro, Amália G Alves, Daniela de Bittencourt Maia, Larissa S Magalhães, Mariana P Paim, Filipe Penteado, Caroline S Gomes, Eder J Lenardão, César A Brüning, Cristiani F Bortolatto
Redox imbalance leads to oxidative stress that causes irreversible cellular damage. The incorporation of the antioxidant element selenium (Se) in the structure of pyridinium salts has been used as a strategy in chemical synthesis and can be useful in drug development. We investigated the antioxidant activity of Se-containing pyridinium salts (named Compounds 3A, 3B, and 3C) through in vitro tests. We focused our study on liver protein carbonylation, liver lipoperoxidation, free radical scavenging activity (1,1-diphenyl-2-picryl-hydrazil [DPPH]; 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid [ABTS]), and enzyme-mimetic activity assays (glutathione S-transferase [GST]-like; superoxide dismutase [SOD]-like)...
September 15, 2023: Journal of Biochemical and Molecular Toxicology