Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#41
JOURNAL ARTICLE
Gisli Thor Axelsson, Thorarinn Jonmundsson, Youngjae Woo, Elisabet Alexandra Frick, Thor Aspelund, Joseph J Loureiro, Anthony P Orth, Lori L Jennings, Gunnar Gudmundsson, Valur Emilsson, Valborg Gudmundsdottir, Vilmundur Gudnason
BACKGROUND: A decline in forced expiratory volume (FEV1) is a hallmark of respiratory diseases that are an important cause of morbidity among the elderly. While some data exist on biomarkers that are related to FEV1, we sought to do a systematic analysis of causal relations of biomarkers with FEV1. METHODS: Data from the population-based AGES-Reykjavik study were used. Serum proteomic measurements were done using 4782 DNA aptamers (SOMAmers). Data from 1479 participants with spirometric data were used to assess the association of SOMAmer measurements with FEV1 using linear regression...
January 18, 2024: Respiratory Research
#42
JOURNAL ARTICLE
Sonja Rieth, Daniel Spliesgar, Jan Orth, Maike Lehner, Renata Kasprzyk, Florian Stengel, Andreas Marx
ADP-ribosylation is a post-translational modification catalyzed by the enzyme family of polyadenosine diphosphate (ADP)-ribose) polymerases (PARPs). This enzymatic process involves the transfer of single or multiple ADP-ribose molecules onto proteins, utilizing nicotinamide adenine dinucleotide (NAD+) as a substrate. It, thus, plays a pivotal role in regulating various biological processes. Unveiling PARP-selective protein targets is crucial for a better understanding of their biological functions. Nonetheless, this task proves challenging due to overlapping targets shared among PARP family members...
January 18, 2024: Chembiochem: a European Journal of Chemical Biology
#43
JOURNAL ARTICLE
Jonathan P Bradfield, Rachel L Kember, Anna Ulrich, Zhanna Balkiyarova, Akram Alyass, Izzuddin M Aris, Joshua A Bell, K Alaine Broadaway, Zhanghua Chen, Jin-Fang Chai, Neil M Davies, Dietmar Fernandez-Orth, Mariona Bustamante, Ruby Fore, Amitavo Ganguli, Anni Heiskala, Jouke-Jan Hottenga, Carmen Íñiguez, Sayuko Kobes, Jaakko Leinonen, Estelle Lowry, Leo-Pekka Lyytikainen, Anubha Mahajan, Niina Pitkänen, Theresia M Schnurr, Christian Theil Have, David P Strachan, Elisabeth Thiering, Suzanne Vogelezang, Kaitlin H Wade, Carol A Wang, Andrew Wong, Louise Aas Holm, Alessandra Chesi, Catherine Choong, Miguel Cruz, Paul Elliott, Steve Franks, Christine Frithioff-Bøjsøe, W James Gauderman, Joseph T Glessner, Vicente Gilsanz, Kendra Griesman, Robert L Hanson, Marika Kaakinen, Heidi Kalkwarf, Andrea Kelly, Joseph Kindler, Mika Kähönen, Carla Lanca, Joan Lappe, Nanette R Lee, Shana McCormack, Frank D Mentch, Jonathan A Mitchell, Nina Mononen, Harri Niinikoski, Emily Oken, Katja Pahkala, Xueling Sim, Yik-Ying Teo, Leslie J Baier, Toos van Beijsterveldt, Linda S Adair, Dorret I Boomsma, Eco de Geus, Mònica Guxens, Johan G Eriksson, Janine F Felix, Frank D Gilliland, Penn Medicine Biobank, Torben Hansen, Rebecca Hardy, Marie-France Hivert, Jens-Christian Holm, Vincent W V Jaddoe, Marjo-Riitta Järvelin, Terho Lehtimäki, David A Mackey, David Meyre, Karen L Mohlke, Juha Mykkänen, Sharon Oberfield, Craig E Pennell, John R B Perry, Olli Raitakari, Fernando Rivadeneira, Seang-Mei Saw, Sylvain Sebert, John A Shepherd, Marie Standl, Thorkild I A Sørensen, Nicholas J Timpson, Maties Torrent, Gonneke Willemsen, Elina Hypponen, Chris Power, Mark I McCarthy, Rachel M Freathy, Elisabeth Widén, Hakon Hakonarson, Inga Prokopenko, Benjamin F Voight, Babette S Zemel, Struan F A Grant, Diana L Cousminer
BACKGROUND: Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Imposition by Translation And Rotation (SITAR) growth curve analysis on ~ 56,000 trans-ancestry samples with repeated height measurements from age 5 years to adulthood. We performed genetic analysis on six phenotypes representing the magnitude, timing, and intensity of the pubertal growth spurt...
January 16, 2024: Genome Biology
#44
JOURNAL ARTICLE
Janina Larissa Bühler, Ulrich Orth
Research suggests that relationship satisfaction changes in systematic ways over the course of a relationship. In this preregistered study, we tested whether relationship satisfaction changes differently as a function of the eventual outcome of the relationship, that is, whether the relationship lasted, whether it was dissolved, and whether people began a new relationship after separation. Data came from a large longitudinal study (the Longitudinal Study of Generations), including 2,268 participants aged 16-90 years, who were assessed at up to seven waves across 20 years...
January 11, 2024: Journal of Personality and Social Psychology
#45
JOURNAL ARTICLE
M Kaufmann, V Orth, T-J Dorwarth, J Benrath, B Gerber, D Ghezel-Ahmadi, C Reißfelder, F Herrle
PURPOSE: We evaluated the effect of the two-stage laparoscopic transversus abdominis plane block (TS-L-TAPB) in comparison to thoracic epidural anaesthesia (TEA) and a one-stage L-TAPB (OS-L-TAPB) in patients who underwent elective laparoscopic bowel resection. METHODS: We compared a TS-L-TAPB (266 mg bupivacaine), which was performed bilaterally at the beginning and end of surgery, with two retrospective cohorts. These were patients who had undergone a TEA (ropivacaine/sufentanil) or an OS-L-TAPB (200 mg ropivacaine) at the beginning of surgery...
January 11, 2024: International Journal of Colorectal Disease
#46
JOURNAL ARTICLE
Thibault R Bongiovanni, Casey J Latario, Youn Le Cras, Evan Trus, Sophie Robitaille, Kerry Swartz, Danica Schmidtke, Maxence Vincent, Artemis Kosta, Jan Orth, Florian Stengel, Riccardo Pellarin, Eduardo P C Rocha, Benjamin D Ross, Eric Durand
The type VI secretion system (T6SS) of Gram-negative bacteria inhibits competitor cells through contact-dependent translocation of toxic effector proteins. In Proteobacteria, the T6SS is anchored to the cell envelope through a megadalton-sized membrane complex (MC). However, the genomes of Bacteroidota with T6SSs appear to lack genes encoding homologs of canonical MC components. Here, we identify five genes in Bacteroides fragilis (tssNQOPR) that are essential for T6SS function and encode a Bacteroidota-specific MC...
January 10, 2024: Nature Communications
#47
JOURNAL ARTICLE
Andreas Neueder, Kerstin Kojer, Zhenglong Gu, Yiqin Wang, Tanja Hering, Sarah Tabrizi, Jan-Willem Taanman, Michael Orth
Huntington disease (HD) predominantly affects the brain causing a mixed movement disorder, cognitive decline and behavioural abnormalities. It also causes a peripheral phenotype involving skeletal muscle. Mitochondrial dysfunction has been reported in tissues of HD models, including skeletal muscle, and lymphoblasts and fibroblasts cultures from HD patients. Mutant huntingtin protein (mutHTT) expression can impair mitochondrial quality control and accelerate mitochondrial ageing. Here we obtained fresh human skeletal muscle, a post-mitotic tissue expressing the mutated HTT allele at physiological levels since birth, and primary cell lines from HTT CAG repeat expansion mutation carriers and matched healthy volunteers to examine whether such a mitochondrial phenotype exists in human HD...
January 9, 2024: Brain
#48
JOURNAL ARTICLE
Damia Noce, Luisa Foco, Dorothea Orth-Höller, Eva König, Giulia Barbieri, Maik Pietzner, Dariush Ghasemi-Semeskandeh, Stefan Coassin, Christian Fuchsberger, Martin Gögele, Fabiola Del Greco M, Alessandro De Grandi, Monika Summerer, Eleanor Wheeler, Claudia Langenberg, Cornelia Lass-Flörl, Peter Paul Pramstaller, Florian Kronenberg, Reinhard Würzner, Cristian Pattaro
Complement is a fundamental innate immune response component. Its alterations are associated with severe systemic diseases. To illuminate the complement's genetic underpinnings, we conduct genome-wide association studies of the functional activity of the classical (CP), lectin (LP), and alternative (AP) complement pathways in the Cooperative Health Research in South Tyrol study (n = 4,990). We identify seven loci, encompassing 13 independent, pathway-specific variants located in or near complement genes (CFHR4, C7, C2, MBL2) and non-complement genes (PDE3A, TNXB, ABO), explaining up to 74% of complement pathways' genetic heritability and implicating long-range haplotypes associated with LP at MBL2...
December 28, 2023: Cell Reports
#49
JOURNAL ARTICLE
Aman Kumar, Simran Kaur Singh, Navkaran Singh, Melissa Chen, Randall Watkins, Sorabh Kapoor, Chirag S Desai
OBJECTIVES: The recipient's gastroduodenal artery is often ligated before the hepatic artery anastomosis during orthotopic liver transplant, to gain either mobility or length of recipient's hepatic artery, potentially protecting the anastomosis by preventing "steal syndrome." In this study, our aim was to evaluate the consequences of gastroduodenal artery ligation and its effect on prevention of hepatic artery thrombosis. MATERIALS AND METHODS: We retrospectively analyzed deceased-donor orthotopic liver transplant procedures (n = 210) performed at a single center between January 2016 and July 2021 to compare outcomes between recipients with (group 1) and recipients without (group 2) gastroduodenal artery ligation...
November 2023: Experimental and Clinical Transplantation
#50
JOURNAL ARTICLE
Elisa Varrone, Domenica Carnicelli, Xiaohua He, Marco Grasse, Karin Stampfer, Silke Huber, Sára Kellnerová, Pier Luigi Tazzari, Francesca Ricci, Paola Paterini, Gianluigi Ardissino, Stefano Morabito, Dorothea Orth-Höller, Reinhard Würzner, Maurizio Brigotti
Typical hemolytic uremic syndrome (HUS) is mainly caused by Shiga toxin-producing Escherichia coli (STEC) releasing Shiga toxin 2 (Stx2). Two different structures of this AB5 toxin have been described: uncleaved, with intact B and A chains, and cleaved, with intact B and a nicked A chain consisting of two fragments, A1 and A2, connected by a disulfide bond. Despite having the same toxic effect on sensitive cells, the two forms differ in their binding properties for circulating cells, serum components and complement factors, thus contributing to the pathogenesis of HUS differently...
December 8, 2023: Toxins
#51
REVIEW
Sean D X Duffy, Hiba Khan, Yael Gelfer, Fergal Monsell
This review presents the principal features of paediatric femoral shaft fractures including the contemporary management strategies and relevant supporting evidence. The article is an overview of information relevant to clinical practice, in addition to preparation for the FRCS (Orth) examination.
December 12, 2023: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
#52
JOURNAL ARTICLE
Ellen R Elias, Lucas E Orth, Amy Li, Libin Xu, Sara M Jones, William B Rizzo
BACKGROUND: Smith-Lemli-Opitz syndrome (SLOS) is an inherited disorder of cholesterol biosynthesis associated with congenital malformations, growth delay, intellectual disability and behavior problems. SLOS is caused by bi-allelic mutations in DHCR7 , which lead to reduced activity of 7-dehydrocholesterol reductase that catalyzes the last step in cholesterol biosynthesis. Symptoms of SLOS are thought to be due to cholesterol deficiency and accumulation of its precursor 7-dehydrocholesterol (7-DHC) and 8-dehydrocholesterol (8-DHC), and toxic oxysterols...
March 2024: Molecular Genetics and Metabolism Reports
#53
JOURNAL ARTICLE
Ellen Verhoef, Andrea G Allegrini, Philip R Jansen, Katherine Lange, Carol A Wang, Angela T Morgan, Tarunveer S Ahluwalia, Christos Symeonides, Else Eising, Marie-Christine Franken, Elina Hypponen, Toby Mansell, Mitchell Olislagers, Emina Omerovic, Kaili Rimfeld, Fenja Schlag, Saskia Selzam, Chin Yang Shapland, Henning Tiemeier, Andrew J O Whitehouse, Richard Saffery, Klaus Bønnelykke, Sheena Reilly, Craig E Pennell, Melissa Wake, Charlotte A M Cecil, Robert Plomin, Simon E Fisher, Beate St Pourcain
BACKGROUND: The number of words children produce (expressive vocabulary) and understand (receptive vocabulary) changes rapidly during early development, partially due to genetic factors. Here, we performed a meta-genome-wide association study of vocabulary acquisition and investigated polygenic overlap with literacy, cognition, developmental phenotypes, and neurodevelopmental conditions, including attention-deficit/hyperactivity disorder (ADHD). METHODS: We studied 37,913 parent-reported vocabulary size measures (English, Dutch, Danish) for 17,298 children of European descent...
December 7, 2023: Biological Psychiatry
#54
JOURNAL ARTICLE
Milan Anton Wolf, Philipp Winter, Stefan Landgraeber, Patrick Orth
BACKGROUND: Scientific progress in the field of knee and hip arthroplasty has enabled the preservation of mobility and quality of life in the case of patients with many primary degenerative and (post-) traumatic joint diseases. This comparative study aims to investigate differences in scientific performance between the leading continents in the field of hip and knee arthroplasty. METHODS: Using specific search terms all studies published by the scientific leading continents Europe, North America, Asia and Oceania listed in the Web of Science databases were included...
2023: Frontiers in Surgery
#55
JOURNAL ARTICLE
Hans Martin Orth, Charlotte Flasshove, Moritz Berger, Sandra Tessa Hattenhauer, Kaja D Biederbick, Rebekka Mispelbaum, Uwe Klein, Jannik Stemler, Matthis Fisahn, Anna D Doleschall, Ben-Niklas Baermann, Eva Koenigshausen, Olga Tselikmann, Alexander Killer, Clara de Angelis, Smaranda Gliga, Johannes Stegbauer, Nikolai Spuck, Gerda Silling, Jürgen K Rockstroh, Christian P Strassburg, Peter Brossart, Jens P Panse, Björn-Erik Ole Jensen, Tom Luedde, Christoph Boesecke, Annkristin Heine, Oliver A Cornely, Malte B Monin
PURPOSE: Prolonged shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed in immunocompromised hosts. Early monotherapy with direct-acting antivirals or monoclonal antibodies, as recommended by the international guidelines, does not prevent this with certainty. Dual therapies may therefore have a synergistic effect. METHODS: This retrospective, multicentre study compared treatment strategies for corona virus disease-19 (COVID-19) with combinations of nirmatrelvir/ritonavir, remdesivir, molnupiravir, and/ or mABs during the Omicron surge...
November 29, 2023: Infection
#56
JOURNAL ARTICLE
Lisa N Kinch, R Dustin Schaeffer, Jing Zhang, Qian Cong, Kim Orth, Nick Grishin
The pandemic Vpar strain RIMD causes seafood-borne illness worldwide. Previous comparative genomic studies have revealed pathogenicity islands in RIMD that contribute to the success of the strain in infection. However, not all virulence determinants have been identified, and many of the proteins encoded in known pathogenicity islands are of unknown function. Based on the EOCD database, we used evolution-based classification of structure models for the RIMD proteome to improve our functional understanding of virulence determinants acquired by the pandemic strain...
November 28, 2023: MSystems
#57
JOURNAL ARTICLE
Robert M DiBlasi, Kellie J Micheletti, Tina Romo, Patrik Malone, Jeff Orth, Evan Richards, Masaki Kajimoto, Justin R Goldstein, Martin Keszler
OBJECTIVE: To investigate a novel servo pressure (SP) setting during high-frequency jet ventilation (HFJV) for a lung protective strategy in a neonatal model of acute respiratory distress. STUDY DESIGN: Comparison of efficacy between variable (standard) and fixed SP settings in a randomized animal study using rabbits (n = 10, mean weight = 1.80 kg) with surfactant deficiency by repeated lung lavages. RESULTS: Rabbits in the fixed SP group had greater peak inspiratory pressure, SP, minute volume, pH, and PaO2 , and lower PaCO2 after lung lavage than the variable SP group...
November 25, 2023: Journal of Perinatology: Official Journal of the California Perinatal Association
#58
JOURNAL ARTICLE
Michael Roland, Stefan Diebels, Marcel Orth, Tim Pohlemann, Bertil Bouillon, Thorsten Tjardes
The evidence base of surgical fracture care is extremely sparse with only few sound RCTs available. It is hypothesized that anthropometric factors relevantly influence mechanical conditions in the fracture gap, thereby interfering with the mechanoinduction of fracture healing. Development of a finite element model of a tibia fracture, which is the basis of an in silico population (n = 300) by systematic variation of anthropometric parameters. Simulations of the stance phase and correlation between anthropometric parameters and the mechanical stimulus in the fracture gap...
November 22, 2023: Scientific Reports
#59
Elisabet A Frick, Valur Emilsson, Thorarinn Jonmundsson, Anna E Steindorsdottir, Erik C B Johnson, Raquel Puerta, Eric B Dammer, Anantharaman Shantaraman, Amanda Cano, Mercè Boada, Sergi Valero, Pablo García-González, Elias F Gudmundsson, Alexander Gudjonsson, Joseph J Loureiro, Anthony P Orth, Nicholas T Seyfried, Allan I Levey, Agustin Ruiz, Thor Aspelund, Lori L Jennings, Lenore J Launer, Valborg Gudmundsdottir, Vilmundur Gudnason
The current demand for early intervention, prevention, and treatment of late onset Alzheimer's disease (LOAD) warrants deeper understanding of the underlying molecular processes which could contribute to biomarker and drug target discovery. Utilizing high-throughput proteomic measurements in serum from a prospective population-based cohort of older adults (n=5,294), we identified 303 unique proteins associated with incident LOAD (median follow-up 12.8 years). Over 40% of these proteins were associated with LOAD independently of APOE- ε 4 carrier status...
November 9, 2023: medRxiv
#60
JOURNAL ARTICLE
Fabiana Lima Monteiro, Cláudia Lúcia Moreira, Vanessa Galego Arias Pecorari, Cássio Cardona Orth, Julio Cesar Joly, Daiane Peruzzo
OBJECTIVES: This systematic review aimed to search the literature for the answer to the following questions: In human studies: Does the osseodensification technique (OD) increase the resonance frequency analysis (RFA) given in implant stability quotient values (ISQ) and the insertion torque value (ITV) compared to conventional technique (SD)? In animal studies: Does the OD increase ISQ, bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) over conventional technique? DATA SOURCES: A search for studies was carried out in eight databases until August 2021...
November 17, 2023: Quintessence International
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
